CYB5R2

CYB5R2
Identifiers
Aliases	CYB5R2 , B5R.2, cytochrome b5 reductase 2
External IDs	OMIM: 608342 MGI: 2444415 HomoloGene: 6182 GeneCards: CYB5R2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	7,677,222 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	107,357,239 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sperm; ; sural nerve; ; skin of abdomen; ; minor salivary gland; ; corpus callosum; ; putamen; ; canal of the cervix; ; Achilles tendon; ; ascending aorta;
	Top expressed in
	spermatid; ; mirror; ; sciatic nerve; ; secondary oocyte; ; morula; ; spermatocyte; ; seminiferous tubule; ; esophagus; ; calvaria; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity ; protein binding ; cytochrome-b5 reductase activity, acting on NAD(P)H ; FAD binding ;
Cellular component	nucleus ; membrane ; endoplasmic reticulum membrane ; mitochondrion ;
Biological process	steroid metabolic process ; sterol biosynthetic process ; steroid biosynthetic process ; lipid metabolism ; bicarbonate transport ;
	Sources:Amigo / QuickGO
Orthologs
	51700
	320635
	ENSG00000166394
	ENSMUSG00000048065
	Q6BCY4
	Q3KNK3
	NM_001001336 ; NM_001302826 ; NM_001302827 ; NM_016229
	NM_001205227 ; NM_177216
	NP_001289755 ; NP_001289756 ; NP_057313
	NP_001192156 ; NP_796190
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166394 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048065 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: cytochrome b5 reductase 2".
↑ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (December 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi: 10.1073/pnas.96.26.14742 . PMC 24718 . PMID 10611283.

External links

Human CYB5R2 genome location and CYB5R2 gene details page in the UCSC Genome Browser .

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Heard-Costa NL, Zillikens MC, Monda KL, et al. (2009). Dermitzakis ET (ed.). "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLOS Genet. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005 . PMID 19557197.
Zhu H, Qiu H, Yoon HW, et al. (1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi: 10.1073/pnas.96.26.14742 . PMC 24718 . PMID 10611283.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Baker MA, Krutskikh A, Curry BJ, et al. (2005). "Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa". Biol. Reprod. 73 (2): 334–42. doi: 10.1095/biolreprod.104.037960 . PMID 15858218.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166394 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048065 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: cytochrome b5 reductase 2".

[pmid10611283-6] Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (December 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi: 10.1073/pnas.96.26.14742 . PMC 24718 . PMID 10611283.

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CYB5R2

Contents

Related Research Articles

References

External links

Further reading