Established | 1998 |
---|---|
Director | Professor Julian Rayner |
Location | The Keith Peters Building, Hills Road, Cambridge CB2 0XY |
Website | https://www.cimr.cam.ac.uk/ |
The Cambridge Institute for Medical Research (CIMR) is an interdisciplinary research institute within the University of Cambridge School of Clinical Medicine. [1] CIMR is on the Cambridge Biomedical Campus, in the Keith Peters Building, a dedicated research building that it shares with the Medical Research Council Mitochondrial Biology Unit. [2]
CIMR's mission is to determine the molecular mechanisms of disease in order to advance human health. [1] CIMR’s research is centered on cellular homeostasis and the diseases that occur when it is disrupted – either by inherited genetic variation or by infection. [3] Bringing together clinical scientists and fundamental biologists, CIMR has deep expertise in protein folding and quality control, membrane trafficking and organelle biology, and how these processes are disrupted in three broad disease areas: rare genetic disease, neurological disease and intracellular infections. [4] Research funding for CIMR research comes from a number of charity and government sources, including the Wellcome Trust. [5]
Sir David Keith Peters was head of the School of Clinical Medicine when CIMR was established in 1998. With significant funding from Wellcome and MRC, a purpose-built, seven storey building with extensive lab facilities was constructed to enable study of the molecular mechanisms of disease. Professor Jenefer Blackwell was CIMR’s first Director (1998–2002), followed by Professor Paul Luzio (2002–2012), Professor Gillian Griffiths (2012–2017), Professor Paul Luzio (Interim Head, 2017–2019), and Professor Julian Rayner (2019–). [6]
Core support has provided by the Wellcome Trust, [7] who continue support projects within the institute. [8]
The following individuals are currently principal investigators: [9]
Up to January 2023, almost 3,000 original research articles have been published featuring authors with CIMR addresses. [10] There are over 300,000 combined further citations of these papers. [3] Additional CIMR outputs and impacts include:
CIMR also has an active public engagement programme, with recent highlights including Inspiring Scientists at CIMR, a four day long hands-on programme providing experience in research and support with University applications for Year 12 students across Cambridgeshire [13] and contributions to RareFest and the Cambridge Science Festival. [14]
As the first dedicated research institute within the School of Clinical Medicine, CIMR has also provided a springboard for the establishment of further Institutes, many of which were founded by Principal Investigators working in CIMR: Hutchison/MRC Research Centre , CRUK Cambridge Institute, Institute of Metabolic Sciences, Anne McClaren Laboratory for Regenerative Medicine, Cambridge Stem Cell Institute, The Cambridge Institute for Therapeutic Immunology and Infectious Disease. [15]
J Paul LuzioFMedSci is a British biologist who is Professor of Molecular Membrane Biology, Department of Clinical Biochemistry at the University of Cambridge, and was Master of St Edmund's College, Cambridge until 2014, as well as Director of the Cambridge Institute for Medical Research.
Richard Henderson is a British molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank."Thanks to his work, we can look at individual atoms of living nature, thanks to cryo-electron microscopes we can see details without destroying samples, and for this he won the Nobel Prize in Chemistry."
The School of Clinical Medicine is the medical school of the University of Cambridge in England. The medical school is considered as being one of the most prestigious in the world, ranking as 1st in The Complete University Guide, followed by Oxford University Medical School, Harvard Medical School, and Stanford School of Medicine and 2nd in the world in the 2023 Times Higher Education Ranking. The Cambridge Graduate Course in Medicine (A101) is the most competitive course offered by the University and in the UK, and is among the most competitive medical programs for entry in the world. The school is located alongside Addenbrooke's Hospital and other institutions in multiple buildings across the Cambridge Biomedical Campus.
The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge, England.
Sir David Keith Peters is a retired Welsh physician and academic. He was Regius Professor of Physic at the University of Cambridge from 1987 to 2005, where he was also head of the School of Clinical Medicine.
The MRC Mitochondrial Biology Unit is a department of the School of Clinical Medicine at the University of Cambridge, funded through a strategic partnership between the Medical Research Council and the University. It is located at the Addenbrooke’s Hospital / Cambridge Biomedical Campus site in Cambridge, England. The unit is concerned with the study of the mitochondrion, as this organelle has a varied and critical role in many aspects of eukaryotic metabolism and is implicated in many metabolic, degenerative, and age-related human diseases.
John Andrew Todd FMedSci FRS is Professor of Precision Medicine at the University of Oxford, director of the Wellcome Center for Human Genetics and the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, in addition to Jeffrey Cheah Fellow in Medicine at Brasenose College. He works in collaboration with David Clayton and Linda Wicker to examine the molecular basis of type 1 diabetes.
Martin Bobrow is a British geneticist, and Emeritus Fellow, Wolfson College, Cambridge.
Ronald Alfred LaskeyFLSW is a British cell biologist and cancer researcher.
Simon Tavaré is the founding Director of the Herbert and Florence Irving Institute of Cancer Dynamics at Columbia University. Prior to joining Columbia, he was Director of the Cancer Research UK Cambridge Institute, Professor of Cancer Research at the Department of Oncology and Professor in the Department of Applied Mathematics and Theoretical Physics (DAMTP) at the University of Cambridge.
Karalyn Eve Patterson, is a British psychologist in Department of Clinical Neurosciences, University of Cambridge and MRC Cognition and Brain Sciences Unit. She is a specialist in cognitive neuropsychologyand an Emeritus Fellow of Darwin College, Cambridge.
Jane Clarke is an English biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge. In 2023, she was elected to the National Academy of Sciences.
David Chaim Rubinsztein FRS FMedSci is the Deputy Director of the Cambridge Institute of Medical Research (CIMR), Professor of Molecular Neurogenetics at the University of Cambridge and a UK Dementia Research Institute Professor.
Sir Douglass Matthew Turnbull is Professor of Neurology at Newcastle University, an Honorary Consultant Neurologist at Newcastle upon Tyne Hospitals NHS Foundation Trust and a director of the Wellcome Trust Centre for Mitochondrial Research.
Vengalil Krishna Kumar Chatterjee is a British endocrinologist. He is a professor of endocrinology in the Department of Medicine at the University of Cambridge and a fellow of Churchill College, Cambridge. He is also the director of the Cambridge Clinical Research Centre, part of the National Institute for Health Research (NIHR).
Sharon Jayne Peacock is a British microbiologist who is Professor of Public Health and Microbiology in the Department of Medicine at the University of Cambridge. Peacock also sits on Cambridge University Council.
Judy Hirst is a British scientist specialising in mitochondrial biology. She is Director of the MRC Mitochondrial Biology Unit at the University of Cambridge.
Nicole Soranzo is an Italian-British senior group leader in human genetics at the Wellcome Sanger Institute, Professor of Human Genetics at the University of Cambridge. She is an internationally recognised Human Geneticist who has focused on the application of cutting edge genomic technologies to study the spectrum of human genetic variation associated with cardio-metabolic and immune diseases. She has led many large-scale discovery efforts including more than 1,000 novel genetic variants associated with cardio-metabolic diseases and their risk factors as well as establishing the HaemGen consortium, which is a worldwide effort to discover genetic determinants of blood cell formation and also interpretation of the downstream consequences of sequence variation through a host of integrative analyses and functional approaches.
The Department of Genetics is a department of the University of Cambridge that conducts research and teaching in genetics.
Professor Patrick Francis Chinnery, FRCP, FRCPath, FMedSci, is a neurologist, clinician scientist, and Wellcome Trust Principal Research Fellow based in the Medical Research Council Mitochondrial Biology Unit and the University of Cambridge, where he is also Professor of Neurology and Head of the Department of Clinical Neurosciences.