David C. Rubinsztein

Last updated

David Rubinsztein
Born
David Chaim Rubinsztein

1963 (age 61–62)
Alma mater University of Cape Town (MBChB, PhD)
Known for autophagy and polyglutamine expansions
Awards
Scientific career
Fields Autophagy
Neurodegenerative diseases [4]
Institutions University of Cambridge
Cambridge Institute for Medical Research
Cambridge Drug Discovery Institute
Thesis Monogenic hypercholesterolemia in South Africans: familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100  (1993)
Doctoral advisor Prof. D.R. van der Westhuyzen
Website

David Chaim Rubinsztein (born 1963) is the Deputy Director of the Cambridge Institute of Medical Research (CIMR), [5] Professor of Molecular Neurogenetics at the University of Cambridge [6] and a UK Dementia Research Institute Professor.

Contents

Education

Rubinsztein completed his Bachelor of Medicine, Bachelor of Surgery (MB ChB) in 1986 and PhD in 1993 in the Medical Research Council/University of Cape Town Unit for the Cell Biology of Atherosclerosis. In 1993 he went to Cambridge as a senior registrar in Genetic Pathology. [7]

Career

In 1997, Rubinsztein acquired his Certificate of Completion of Specialist Training at the University of Cambridge. He was appointed to a Personal Readership at the University of Cambridge in 2003. In 2005, he was promoted to Professor of Molecular Neurogenetics at the University of Cambridge (personal chair). He has been an author on more than 400 scientific papers, [4] [8] and was ranked as the 4th most cited European author from 2007 to 2013 in cell biology. [9] Rubinsztein has been invited to give talks at major international conferences, including Gordon Research Conferences and Keystone Symposia. [10] [11] [12]

Research

Rubinsztein has made major contributions to the field of neurodegeneration [4] with his laboratory's discovery that autophagy regulates the levels of intracytoplasmic aggregate-prone proteins that cause many neurodegenerative diseases, including Huntington's, Parkinson's and Alzheimer's disease. [13] [14] [15] [16] [17] His lab has found that autophagy may be inhibited in various neurodegenerative diseases [18] and has elucidated the pathological consequences of autophagy compromise. [19] In addition his research has advanced the basic understanding of autophagy, identifying the plasma membrane as a source of autophagosome membrane [20] and characterising early events in autophagosome biogenesis,. [21] [22] [23] Furthermore, he studied how lysosomal positioning regulates autophagy. [24] His goal is to understand the links between these diseases and autophagy. He is currently focused on understanding how to induce autophagy in vivo to remove toxic proteins and avoid the development of neurodegenerative disease [5] [25]

Honours and awards

Rubinsztein has won numerous awards including:

References

  1. ↑ "14 Academy Fellows elected to the Royal Society in 2017 | the Academy of Medical Sciences".
  2. 1 2 "EMBO people: David C. Rubinsztein". people.embo.org.
  3. 1 2 Anon (2017). "Professor David Rubinsztein FRS". London: royalsociety.org.
  4. 1 2 3 David C. Rubinsztein publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  5. 1 2 "Professor David C. Rubinsztein". University of Cambridge.[ permanent dead link ]
  6. ↑ "Professor David Rubinsztein :: Cambridge Neuroscience". www.neuroscience.cam.ac.uk. Retrieved 8 January 2018.
  7. ↑ F1000 Prime Faculty Member
  8. ↑ Research Gate
  9. ↑ "Publication analysis 2007–2013, Cell Biology" (PDF). Archived from the original (PDF) on 4 March 2016. Retrieved 26 November 2015.
  10. ↑ "Centre for Science and Policy". University of Cambridge.
  11. ↑ Renna, M.; Jimenez-Sanchez, M.; Sarkar, S.; Rubinsztein, D. C. (2010). "Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases". Journal of Biological Chemistry . 285 (15): 11061–11067. doi: 10.1074/jbc.R109.072181 . ISSN   0021-9258. PMC   2856980 . PMID   20147746. Open Access logo PLoS transparent.svg
  12. ↑ Renna, M.; Jimenez-Sanchez, M.; Sarkar, S.; Rubinsztein, D. C. (2010). "Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases". The Journal of Biological Chemistry. 285 (15): 11061–11067. doi: 10.1074/jbc.R109.072181 . PMC   2856980 . PMID   20147746.
  13. ↑ Rubinsztein, D. C. (2012). "Autophagy modulation as a potential therapeutic target for diverse diseases". Nature Reviews Drug Discovery . 11 (9): 709–730. doi:10.1038/nrd3802. PMC   3518431 . PMID   22935804.
  14. ↑ Ravikumar, B.; Rubinsztein, D. C. (2004). "Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease". Nature Genetics . 36 (6): 585–595. doi: 10.1038/ng1362 . PMID   15146184.
  15. ↑ Analytics, Clarivate. "David Rubinsztein Interview - Special Topic of Autophagy - ScienceWatch.com". archive.sciencewatch.com. Retrieved 8 January 2018.
  16. ↑ Davies, J. E.; Rubinsztein, D. C. (2005). "Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice". Nature Medicine . 11 (6): 672–677. doi:10.1038/nm1242. PMID   15864313. S2CID   13190118.
  17. ↑ Sarkar, S.; Rubinsztein, D. C. (2007). "Small molecules enhance autophagy and reduce toxicity in Huntington's disease models". Nature Chemical Biology. 3 (6): 331–338. doi:10.1038/nchembio883. PMC   2635561 . PMID   17486044.
  18. ↑ Winslow, A. R.; Rubinsztein, D. C. (2010). "α-Synuclein impairs macroautophagy: implications for Parkinson's disease". The Journal of Cell Biology. 190 (6): 1023–1037. doi:10.1083/jcb.201003122. PMC   3101586 . PMID   20855506.
  19. ↑ Ravikumar, B.; Rubinsztein, D. C. (2005). "Dynein mutations impair autophagic clearance of aggregate-prone proteins". Nature Genetics. 37 (7): 771–776. doi:10.1038/ng1591. PMID   15980862. S2CID   7628772.
  20. ↑ Ravikumar, B.; Rubinsztein, D. C. (2010). "Plasma membrane contributes to the formation of pre-autophagosomal structures". Nature Cell Biology . 12 (8): 747–757. doi:10.1038/ncb2078. PMC   2923063 . PMID   20639872.
  21. ↑ Moreau, K.; Rubinsztein, D. C. (2011). "Autophagosome precursor maturation requires homotypic fusion". Cell . 146 (2): 303–317. doi:10.1016/j.cell.2011.06.023. PMC   3171170 . PMID   21784250.
  22. ↑ Puri, C.; Rubinsztein, D. C. (2013). "Diverse autophagosome membrane sources coalesce in recycling endosomes". Cell. 154 (6): 1285–1299. doi:10.1016/j.cell.2013.08.044. PMC   3791395 . PMID   24034251.
  23. ↑ Vicinanza, M.; Rubinsztein, D. C. (2015). "PI(5)P regulates autophagosome biogenesis". Molecular Cell. 57 (2): 219–234. doi:10.1016/j.molcel.2014.12.007. PMC   4306530 . PMID   25578879.
  24. ↑ Korolchuk, V. I.; Rubinsztein, D. C. (2011). "Lysosomal positioning coordinates cellular nutrient responses". Nature Cell Biology. 13 (4): 453–460. doi:10.1038/ncb2204. PMC   3071334 . PMID   21394080.
  25. ↑ "Autophagy, a guardian against neurodegeneration - Part 2 - David Rubinsztein". SENS Research Foundation. 27 November 2013. Archived from the original on 8 December 2015. Retrieved 8 January 2018.
  26. ↑ Anon (2004). "Professor David Rubinsztein FMedSci". acmedsci.ac.uk. London: Academy of Medical Sciences. Archived from the original on 4 March 2016. Retrieved 26 November 2015.
  27. ↑ "Wellcome Trust". Archived from the original on 2 October 2015. Retrieved 26 November 2015.
  28. ↑ "Editor biographies". Nature.
  29. ↑ "Funded People and Projects - Grant Funding | Wellcome".
  30. 1 2 Thomson Reuters
  31. ↑ "Labtimes: Publication Statistics: Cell Biology". Archived from the original on 29 July 2017. Retrieved 12 April 2016.
  32. ↑ "2017 Award Winners". biochemistry.org. Archived from the original on 4 June 2016. Retrieved 12 April 2016.
  33. ↑ "Highly Cited Researchers - the Most Influential Scientific Minds".
  34. ↑ "Highly Cited Researchers".
  35. ↑ "Main Programme 212th Scientific Meeting of the Pathological Society of Great Britain & Ireland".[ permanent dead link ]
  36. ↑ "Highly Cited Researchers". 13 November 2024.
  37. ↑ "Highly Cited Researchers". Archived from the original on 24 November 2021. Retrieved 24 November 2021.
  38. ↑ "Member > Rubinsztein David".
  39. ↑ "Highly Cited Researchers". 13 November 2024.
  40. ↑ "Highly Cited Researchers". 13 November 2024.
  41. ↑ "Scientific Research Award Recipients".
  42. ↑ "Highly Cited Researchers". 13 November 2024.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.