U.S. Route 340 is a spur route of US 40, and runs from Greenville, Virginia, to Frederick, Maryland. In Virginia, it runs north–south, parallel and east of US 11, from US 11 north of Greenville via Waynesboro, Grottoes, Elkton, Luray, Front Royal, and Berryville to the West Virginia state line. A short separate piece crosses northern Loudoun County on its way from West Virginia to Maryland.
Maryland Route 201 is a state highway in the U.S. state of Maryland. Known for most of its length as Kenilworth Avenue, the highway runs 9.40 miles (15.13 km) from the District of Columbia boundary in Tuxedo, where the highway continues south as District of Columbia Route 295, north to MD 212 in Beltsville. MD 201 is a four to six-lane divided highway that connects Washington, D.C., with the northern Prince George's County municipalities of Cheverly, Bladensburg, Edmonston, Riverdale Park, College Park, Berwyn Heights, and Greenbelt. The highway also provides part of the connections from Interstate 95 (I-95)/I-495 to a pair of Washington Metro stations. MD 201 was built as two separate highways in the late 1920s: MD 201 from Washington, D.C., to Bladensburg and MD 205 from Bladensburg to Greenbelt. These highways, some of which became MD 769, were replaced with a relocated Kenilworth Avenue in the mid 1950s, including the Kenilworth Interchange with U.S. Route 50 and the Baltimore–Washington Parkway in Tuxedo. MD 201 was extended north to Beltsville in the early 1960s. The Maryland State Highway Administration (MDSHA) plans to extend MD 201 north toward Laurel.
Clara Barton Parkway is an automobile parkway in the U.S. state of Maryland and the District of Columbia. The highway runs 6.8 miles (10.9 km) from MacArthur Boulevard in Carderock, Maryland, east to Canal Road at the Chain Bridge in Washington. Clara Barton Parkway is a two- to four-lane parkway that parallels the Potomac River and the Chesapeake and Ohio Canal (C&O) in southwestern Montgomery County, Maryland, and the far western corner of Washington. The parkway provides access to the communities of Cabin John and Glen Echo and several units of the Chesapeake and Ohio Canal National Historical Park. The Maryland portion of the George Washington Memorial Parkway was constructed from Carderock past Interstate 495 (I-495) to Glen Echo in the early to mid-1960s. The parkway was proposed to continue west to Great Falls and east to Georgetown. However, these proposals never came to fruition and the parkway was extended only to the Chain Bridge in the early 1970s. The Maryland portion of the George Washington Memorial Parkway was renamed in 1989 for Clara Barton, the founder of the American Red Cross, and whose original headquarters is located in Glen Echo.
West Virginia Route 28 is a north–south route through the Potomac Highlands of the U.S. state of West Virginia. The southern terminus of the route is at West Virginia Route 39 in Huntersville. The northern terminus is at the Maryland state line in Wiley Ford, where the route continues into Cumberland as Canal Parkway upon crossing the North Branch Potomac River.
West Virginia Route 480 is a 5.64-mile-long (9.08 km) state highway in the U.S. state of West Virginia. Known for most of its length as Kearneysville Pike, the highway extends from WV 115 in Kearneysville north to the Maryland state line at the Potomac River in Shepherdstown, from where the highway continues as Maryland Route 34. The route is one of the main north–south highways of northern Jefferson County and passes through the campus of Shepherd University. WV 480 was originally established in the early 1920s as West Virginia Route 48. The highway was paved in the mid-1920s, which included a different routing through Shepherdstown. WV 48's present routing through the town was established in the late 1930s when the first James Rumsey Bridge was completed; that bridge was replaced with the current bridge in the mid-2000s. WV 48 was renumbered to WV 480 in the mid-1970s after U.S. Route 48 was established in West Virginia and Maryland.
Maryland Route 135 is a state highway in the U.S. state of Maryland. Known for most of its length as Maryland Highway, the state highway runs 29.00 miles (46.67 km) from U.S. Route 219 in Oakland in Garrett County east to US 220 in McCoole in Allegany County. MD 135 is the main link between the towns of Oakland, Mountain Lake Park, Loch Lynn Heights, and Deer Park on the Appalachian Plateau and the communities of Bloomington, Luke, Westernport, and McCoole in the upper valley of the North Branch Potomac River. These groups of towns are separated by Backbone Mountain.
Maryland Route 190 is a state highway in the U.S. state of Maryland. Known as River Road, the highway runs 15.88 miles (25.56 km) from MD 112 near Seneca east to Western Avenue at the District of Columbia boundary in Bethesda. MD 190 parallels the Potomac River through the affluent southwestern Montgomery County communities of Potomac and Bethesda and connects those suburbs with Interstate 495 (I-495). River Road was paved from Washington, D.C. west through part of Bethesda in the early 1910s. A second section of MD 190 was constructed through Potomac in the mid-1920s. The Bethesda and Potomac portions of the route were unified in the late 1920s. MD 190 was extended west toward Seneca in two steps in 1950 and the early 1970s. The highway was expanded to a four-lane divided highway through Bethesda in the early 1960s.
Maryland Route 17 is a state highway in the U.S. state of Maryland. The state highway begins at the Virginia state line at the Potomac River in Brunswick, where the highway continues south as Virginia State Route 287. MD 17 runs 29.49 miles (47.46 km) north from the Brunswick Bridge to the Frederick–Washington county line near Wolfsville. The state highway serves as the main north–south highway of the Middletown Valley of western Frederick County. MD 17 connects Brunswick and Wolfsville with Rosemont, Burkittsville, Middletown, and Myersville. The state highway also connects those communities with the valley's main east–west highways, which include U.S. Route 340, US 40 Alternate, Interstate 70 (I-70), and US 40.
Maryland Route 144 is a collection of state highways in the U.S. state of Maryland. These highways are sections of old alignment of U.S. Route 40 between Cumberland and Baltimore. Along with US 40 Scenic, US 40 Alternate, and a few sections of county-maintained highway, MD 144 is assigned to what was once the main highway between the two cities, connecting those endpoints with Hancock, Hagerstown, Frederick, New Market, Mount Airy, Ellicott City, and Catonsville. MD 144 has seven disjoint sections of mainline highway that pass through the Appalachian Mountains in Allegany and Washington counties and the rolling Piedmont of Frederick, Carroll, Howard, and Baltimore counties.
U.S. Route 40 in the U.S. state of Maryland runs from Garrett County in Western Maryland to Cecil County in the state's northeastern corner. With a total length of 221 miles (356 km), it is the longest numbered highway in Maryland. Almost half of the road overlaps or parallels with Interstate 68 (I-68) or I-70, while the old alignment is generally known as US 40 Alternate, US 40 Scenic, or Maryland Route 144. West of Baltimore, in the Piedmont and Appalachian Mountains / Blue Ridge region of the Western Maryland panhandle of the small state, the portions where it does not overlap an Interstate highway are mostly two-lane roads. The portion northeast of Baltimore going toward Wilmington in northern Delaware and Philadelphia in southeastern Pennsylvania is a four-lane divided highway, known as the Pulaski Highway. This section crosses the Susquehanna River at the north end of the Chesapeake Bay on the Thomas J. Hatem Memorial Bridge.
U.S. Route 15 (US 15) is a part of the United States Numbered Highway System that runs from Walterboro, South Carolina, north to Painted Post, New York. In Maryland, the highway runs 37.85 miles (60.91 km) from the Virginia state line at the Potomac River in Point of Rocks north to the Pennsylvania state line near Emmitsburg. Known for most of its length as Catoctin Mountain Highway, US 15 is the primary north–south highway of Frederick County. The highway connects the county seat of Frederick with Point of Rocks, Leesburg, Virginia, and Charles Town, West Virginia, to the south and with Thurmont, Emmitsburg, and Gettysburg, Pennsylvania, to the north. US 15 is a four-lane divided highway throughout the state except for the portion between the Point of Rocks Bridge and the highway's junction with US 340 near Jefferson. The highway is a freeway along its concurrency with US 340 and through Frederick, where the highway meets US 40 and Interstate 70 (I-70). US 15 has a business route through Emmitsburg.
U.S. Route 11 (US 11) is a part of the United States Numbered Highway System that runs from New Orleans, Louisiana, to Rouses Point, New York. In Maryland, the federal highway runs 12.83 miles (20.65 km) from the West Virginia state line at the Potomac River in Williamsport north to the Pennsylvania state line near Maugansville. US 11 is the primary north–south surface highway in central Washington County, connecting Hagerstown with Williamsport to the south and Hagerstown Regional Airport to the north. The federal highway was once a major long-distance highway, but that role has been assumed by Interstate 81 (I-81), which parallels US 11 not only in Maryland but for most of its course from Tennessee to Upstate New York. US 11 is maintained by the Maryland State Highway Administration except for the municipally-maintained portions within the corporate limits of Williamsport and Hagerstown.
Maryland Route 51 is a state highway in the U.S. state of Maryland. Known for most of its length as Oldtown Road, the state highway runs 25.53 miles (41.09 km) from an interchange with Interstate 68 (I-68) in Cumberland south to the West Virginia state line at the Potomac River, where the highway continues east as West Virginia Route 9 toward Paw Paw. Around Cumberland, MD 51 is a major highway that provides a bypass of the South End neighborhood of that city and access to industrial areas along the North Branch Potomac River. South of North Branch, MD 51 is a rural highway connecting small communities along the river in southeastern Allegany County, including Oldtown. Documentation from the Maryland State Highway Administration depict the highway as following an east-west alignment, but all signage indicates a north-south road.
Maryland Route 34 is a state highway in the U.S. state of Maryland. Known for most of its length as Shepherdstown Pike, the state highway begins at the West Virginia state line at the Potomac River, where the highway continues south as West Virginia Route 480 through Shepherdstown. The state highway runs 9.95 miles (16.01 km) east to U.S. Route 40 Alternate in Boonsboro. MD 34 is the main east–west highway of southern Washington County, connecting Shepherdstown and Boonsboro with Sharpsburg and Keedysville. The state highway, which was preceded by the Boonsboro and Sharpstown Turnpike, was constructed as a modern highway in the late 1910s and early 1920s. MD 34's bypass of Keedysville opened around 1960. The western end of the state highway has had three bridges. A 19th-century bridge was destroyed in a 1936 flood and replaced by the James Rumsey Bridge in 1939. The present bridge, also named for James Rumsey, opened in 2005.
Maryland Route 38 is a state highway in the U.S. state of Maryland. Known as Kitzmiller Road, the state highway runs 5.67 miles (9.12 km) from the West Virginia state line at the North Branch Potomac River in Kitzmiller, where the highway continues south as West Virginia Route 42, north to MD 135 on top of Backbone Mountain. MD 38 connects Kitzmiller with the rest of Garrett County and across the North Branch Potomac River to Blaine and Elk Garden in western Mineral County. The state highway was constructed in the late 1920s and early 1930s. MD 38 originally ran from U.S. Route 219 near Thayerville through Deer Park and Altamont to Kitzmiller. The state highway was truncated at Backbone Mountain when MD 135 was extended west to Oakland in the mid-1950s.
Maryland Route 63 is a state highway in the U.S. state of Maryland. The state highway runs 16.99 miles (27.34 km) from MD 65 in Fairplay north to the Pennsylvania state line near Cearfoss, where the highway continues as Pennsylvania Route 163. MD 63 is an L-shaped route that passes through central Washington County on the south and west sides of Hagerstown. The state highway connects with multiple local and long-distance highways that serve Hagerstown, including Interstate 81 (I-81) and U.S. Route 11 in Williamsport and I-70 and US 40 in Huyett. MD 63 also joins MD 68 in a concurrency through Williamsport.
U.S. Route 220 is a part of the U.S. Highway System that runs from Rockingham, North Carolina, to South Waverly, Pennsylvania. In Maryland, the federal highway runs 27.30 miles (43.94 km) from the West Virginia state line at the North Branch Potomac River in McCoole north to the Pennsylvania state line in Dickens. Known as McMullen Highway for much of its length in Maryland, US 220 is the primary north–south route in central Allegany County, connecting Cumberland with its southern suburbs and Keyser, West Virginia to the south and Bedford, Pennsylvania to the north. The federal highway is part of the National Highway System between the West Virginia state line and Maryland Route 53 in Cresaptown and between Interstate 68 (I-68), with which it is concurrent through Cumberland, and the Pennsylvania state line.
Randolph Road is a county highway in the U.S. state of Maryland. The highway is the major component of a mostly four- to six-lane 16.8-mile (27.0 km) highway spanning southern Montgomery County and northwestern Prince George's County that also includes Montrose Road, Josiah Henson Memorial Parkway, and Cherry Hill Road, and forms an important link between eastern Montgomery County and Rockville. Montrose Road begins at Maryland Route 189 in Potomac. The highway heads east through a junction with Interstate 270 (I-270) before the main course continues as Josiah Henson Memorial Parkway in North Bethesda. Josiah Henson Memorial Parkway continues through a junction with MD 355, east of which the highway becomes Randolph Road. Randolph Road intersects MD 586 and MD 185 in Wheaton, MD 97 in Glenmont, and MD 650 in Colesville. The highway continues southeast toward Fairland, where it meets U.S. Route 29. The highway continues from US 29 as Cherry Hill Road through an intersection with MD 212 in Calverton before reaching its eastern end at US 1 in College Park.
Maryland Route 189 is a state highway in the U.S. state of Maryland. Known as Falls Road, the highway runs 5.05 miles (8.13 km) from MD 190 in Potomac to Great Falls Road and Maryland Avenue in Rockville. MD 189 connects Rockville with Potomac and the Great Falls of the Potomac River in southwestern Montgomery County. The highway was constructed from Rockville to Potomac by the early 1920s and extended toward Great Falls in the early 1930s. MD 189 was expanded to a divided highway around its newly-constructed interchange with Interstate 270 (I-270) in the late 1980s. The highway was truncated at both ends in the late 1990s.
Chesapeake and Ohio Canal Scenic Byway 
WV 28 in Cumberland 
MD 51 in Cumberland
