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Caenorhabditis elegans is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek caeno- (recent), rhabditis (rod-like) and Latin elegans (elegant). In 1900, Maupas initially named it Rhabditides elegans. Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus.
The Planetary Society is an American internationally-active non-governmental nonprofit organization. It is involved in research, public outreach, and political space advocacy for engineering projects related to astronomy, planetary science, and space exploration. It was founded in 1980 by Carl Sagan, Bruce Murray, and Louis Friedman, and has about 60,000 members from more than 100 countries around the world.
Steven Weldon Squyres is an American geologist and planetary scientist. He was the James A. Weeks Professor of Physical Sciences at Cornell University in Ithaca, New York. His research area is in planetary sciences, with a focus on large solid bodies in the Solar System such as the terrestrial planets and the moons of the Jovian planets. Squyres was the principal investigator of the Mars Exploration Rover Mission (MER).
Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM is an American biologist whose research on the nematode worm Caenorhabditis elegans was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis of many diseases".
Sir John Edward Sulston was a British biologist and academic who won the Nobel Prize in Physiology or Medicine for his work on the cell lineage and genome of the worm Caenorhabditis elegans in 2002 with his colleagues Sydney Brenner and Robert Horvitz at the MRC Laboratory of Molecular Biology. He was a leader in human genome research and Chair of the Institute for Science, Ethics and Innovation at the University of Manchester. Sulston was in favour of science in the public interest, such as free public access of scientific information and against the patenting of genes and the privatisation of genetic technologies.
Planetary protection is a guiding principle in the design of an interplanetary mission, aiming to prevent biological contamination of both the target celestial body and the Earth in the case of sample-return missions. Planetary protection reflects both the unknown nature of the space environment and the desire of the scientific community to preserve the pristine nature of celestial bodies until they can be studied in detail.
Cynthia Jane Kenyon is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm Caenorhabditis elegans. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the University of California, San Francisco (UCSF).
James F. Bell III is a professor of Astronomy at Arizona State University, specializing in the study of planetary geology, geochemistry and mineralogy using data obtained from telescopes and from various spacecraft missions. Bell's active research has involved the NASA Mars Pathfinder, Near Earth Asteroid Rendezvous (NEAR), Comet Nucleus Tour (CONTOUR), 2001 Mars Odyssey, Mars Reconnaissance Orbiter, Lunar Reconnaissance Orbiter, and the Mars Science Laboratory missions. His book Postcards from Mars includes many images taken by the Mars rovers. Bell is currently an editor of the space science journal Icarus and president of The Planetary Society. He has served as the lead scientist in charge of the Panoramic camera (Pancam) color imaging system on Mars rovers Spirit and Opportunity.
John Graham White is an Emeritus Professor of Anatomy and Molecular Biology at the University of Wisconsin–Madison. His research interests are in the biology of the model organism Caenorhabditis elegans and laser microscopy.
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The nematodes, roundworms or eelworms constitute the phylum Nematoda. They are a diverse animal phylum inhabiting a broad range of environments. Most species are free-living, feeding on microorganisms, but many species are parasitic. The parasitic worms (helminths) are the cause of soil-transmitted helminthiases.
The nematode worm Caenorhabditis elegans was first studied in the laboratory by Victor Nigon and Ellsworth Dougherty in the 1940s, but came to prominence after being adopted by Sydney Brenner in 1963 as a model organism for the study of developmental biology using genetics. In 1974, Brenner published the results of his first genetic screen, which isolated hundreds of mutants with morphological and functional phenotypes, such as being uncoordinated. In the 1980s, John Sulston and co-workers identified the lineage of all 959 cells in the adult hermaphrodite, the first genes were cloned, and the physical map began to be constructed. In 1998, the worm became the first multi-cellular organism to have its genome sequenced. Notable research using C. elegans includes the discoveries of caspases, RNA interference, and microRNAs. Eight scientists have won the Nobel Prize for their work on C. elegans.
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OpenWorm is an international open science project for the purpose of simulating the roundworm Caenorhabditis elegans at the cellular level. Although the long-term goal is to model all 959 cells of the C. elegans, the first stage is to model the worm's locomotion by simulating the 302 neurons and 95 muscle cells. This bottom up simulation is being pursued by the OpenWorm community.
Judith Kimble is a Henry Vilas Professor of Biochemistry, Molecular Biology, Medical Genetics and Cell and Regenerative Biology at the University of Wisconsin–Madison and Investigator with the Howard Hughes Medical Institute (HHMI). Kimble’s research focuses on the molecular regulation of animal development.
Caenorhabditis elegans- microbe interactions are defined as any interaction that encompasses the association with microbes that temporarily or permanently live in or on the nematode C. elegans. The microbes can engage in a commensal, mutualistic or pathogenic interaction with the host. These include bacterial, viral, unicellular eukaryotic, and fungal interactions. In nature C. elegans harbours a diverse set of microbes. In contrast, C. elegans strains that are cultivated in laboratories for research purposes have lost the natural associated microbial communities and are commonly maintained on a single bacterial strain, Escherichia coli OP50. However, E. coli OP50 does not allow for reverse genetic screens because RNAi libraries have only been generated in strain HT115. This limits the ability to study bacterial effects on host phenotypes. The host microbe interactions of C. elegans are closely studied because of their orthologs in humans. Therefore, the better we understand the host interactions of C. elegans the better we can understand the host interactions within the human body.
Project Starlight is a research project of the University of California, Santa Barbara to develop a fleet of laser beam-propelled interstellar probes and sending them to a star neighboring the Solar System, potentially Alpha Centauri. The project aims to send organisms on board the probe.
Lisa Pratt is an American biogeochemist and astrobiologist who served as the 7th Planetary Protection Officer for NASA from 2018 to 2021 under President Donald Trump. Her academic work as a student, professor, and researcher on organisms and their respective environments prepared her for the position, in which she was responsible for protecting Earth and other planets in the solar system from traveling microbes. She is a Provost Professor Emeritus of Earth and Atmospheric Sciences for Indiana University Bloomington.
Eileen Southgate is a British biologist who mapped the complete nervous system of the roundworm Caenorhabditis elegans, together with John White, Nichol Thomson, and Sydney Brenner. The work, done largely by hand-tracing thousands of serial section electron micrographs, was the first complete nervous system map of any animal and it helped establish C. elegans as a model organism. Among other projects carried out as a laboratory assistant at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), Southgate contributed to work on solving the structure of hemoglobin with Max Perutz and John Kendrew, and investigating the causes of sickle cell disease with Vernon Ingram.
References
- ↑ Conley, Catharine Anastasia (1995). Spatial and temporal localization of the defects associated with Petunia cytoplasmic male sterility (Ph.D.). Cornell University. OCLC 693242966 – via ProQuest.
- ↑ "Catharine Conley". Archived from the original on July 16, 2011. Retrieved May 4, 2009.
- ↑ Person Report: Catharine Conley
- ↑ International Caenorhabditis elegans Experiment: Physiological Study of Nematode Worms in Weightlessness (ICE-First) 2009-02-20
- ↑ Viso, Michel. "International Ceonorhabditis elegans Experiment First flight: Science Goals and Objectives". Dutch Experimental Support Center.
- ↑ Columbia Survivors 2006-01-01 Archived January 25, 2007, at the Wayback Machine
- ↑ Leary, Warren E. (October 9, 2007). "In NASA's Sterile Areas, Plenty of Robust Bacteria". The New York Times .
- ↑ Shades of Gravity: Interview with Catharine Conley 2007-11-05[ dead link ]
- ↑ Conley, Catharine A. (March 2008). "Planetary protection considerations for mars sample return" (PDF). Lunar and Planetary Institute .
- ↑ "Meet Cassie Conley". Archived from the original on April 20, 2009. Retrieved May 4, 2009.
- ↑ "Spaceward bound: Cassie Conley". Archived from the original on May 10, 2009. Retrieved May 4, 2009.
- ↑ "Catharine Conley Pipl Profile". Archived from the original on October 2, 2011. Retrieved May 4, 2009.
- ↑ Voosen, Paul (February 22, 2018). "NASA planetary protection officer suggests loosening limits on exploring Mars for life". Science . doi:10.1126/science.aat4041.
- ↑ "Indiana University astrobiologist named planetary protection officer at NASA". Indiana University. January 18, 2018.
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