Cemento-osseous dysplasia

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Cemento-osseous dysplasia
Other namesFlorid osseous dysplasia
Florid osseous dysplasia.png
Florid osseous dysplasia of the mandible
Specialty Dentistry
Symptoms May or may not be symptomatic, radiographic finding
Complications Infection with extractions or abscessed teeth, unnecessary root canals
Usual onset20-30 years
TypesLocalized, generalized
CausesCongenital
Diagnostic method X-ray, CBCT scan, vitality testing of teeth
Differential diagnosis Paget's disease of bone, fibrous dysplasia, Tooth abscess
TreatmentNone required

Cemento-osseous dysplasia (COD) is a benign condition of the jaws that may arise from the fibroblasts of the periodontal ligaments. It is most common in middle-aged females of African descent. The three types are periapical cemental dysplasia (common in those of African descent), focal cemento-osseous dysplasia (Caucasians), and florid cemento-osseous dysplasia (African descent). Periapical COD occurs most commonly in the mandibular anterior teeth while focal COD appears predominantly in the mandibular posterior teeth. Florid COD is an extensive variant of periapical COD where lesions occur in multiple quadrants which can encompass the maxilla and mandible, and infrequently can cause jawbone deformity. [1]

Contents

Disease process

COD occurs when fibrous tissue containing osteoid and cementoid replace bone, and may be due to pathogenic mutations in various signaling pathways. [2] It is a self-limiting and dysplastic process. [3]

Risk factors

Risk factors for experiencing symptoms associated with COD include the size of the lesion, apical involvement, and infection within the lesion. [3] Patients with larger lesions tend to experience symptoms, likely due to the growth impinging on adjacent structures. [3] Lesions in proximity to the apex of a tooth, especially those associated with caries or periodontal disease, may have a greater chance of becoming infected. [3] Lastly, local infection within a COD lesion, often leading to necrosis of the area, is another risk factor for symptomatic COD. [3]

Symptoms

Most patients are asymptomatic and the condition is only found during radiographic analyses. In a study, 14.7% of patients were symptomatic, with pain being the most common symptom and may be associated with osteomyelitis. [2] Other symptoms may include hypoesthesia, paresthesia, and discomfort. [3] In rare instances, patients may experience associated facial swelling with the presence or absence of pain due to concurrent infection. [4] Patients experiencing symptoms also tend to be older and have the periapical form of cemento-osseous dysplasia. [3] Studies have demonstrated that these patients tend to be in the fourth decade of life, and approximately 70% of COD cases are located near teeth apices. [3]

Diagnosis

Diagnosis is based on clinical and radiographic observations, and in rare cases, biopsy may be performed. [3] Diagnosis is important so that the treating doctor does not confuse it for another periapical disease such as rarefying osteitis or condensing osteitis. Incorrect diagnosis could lead to unnecessary root canal treatments, or biopsy or surgical intervention which can be invasive and increase the risk of infection. [5] A pulp vitality test such as a cold test or electric pulp test can aid in diagnosis, since COD generally does not compromise pulp vitality. [6] COD can be found in individuals of all ages and ethnic backgrounds, but it has been observed more frequently in individuals of African, East Asian, and Asian descent. [7] Cone-beam computed tomography (CBCT) has proven useful in distinguishing between COD and periapical cysts, when examined with quantitative texture analysis using specialized software. [5]

Treatment

Asymptomatic patients do not typically require treatment. For these patients, dental prophylaxis and regular monitoring are the primary recommended treatment steps which will help prevent future risk of infection. [8] Symptomatic patients may receive treatment options that include surgical curettage with bleeding stimulation or pulp vitality testing in areas showing periapical inflammation. [8]

xray and CBCT scans of periapical cemental dysplasia Xray and CBCT of periapical cementral dysplasia.png
xray and CBCT scans of periapical cemental dysplasia

Related Research Articles

<span class="mw-page-title-main">Pulp (tooth)</span> Part in the center of a tooth made up of living connective tissue and cells called odontoblasts

The pulp is the connective tissue, nerves, blood vessels, and odontoblasts that comprise the innermost layer of a tooth. The pulp's activity and signalling processes regulate its behaviour.

<span class="mw-page-title-main">Alveolar osteitis</span> Inflammation of the alveoli (tooth sockets in the jawbones)

Alveolar osteitis, also known as dry socket, is inflammation of the alveolar bone. Classically, this occurs as a postoperative complication of tooth extraction.

An oral medicine or stomatology doctor/dentist has received additional specialized training and experience in the diagnosis and management of oral mucosal abnormalities including oral cancer, salivary gland disorders, temporomandibular disorders and facial pain, taste and smell disorders; and recognition of the oral manifestations of systemic and infectious diseases. It lies at the interface between medicine and dentistry. An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region.

Gigantiform cementoma is a rare, autosomal dental tumor. The tumor is benign, but without intervention it can result in severe disfigurement of the jaw and of the facial skeleton. It is commonly found in the mandible and the maxilla but it is less commonly found in the maxilla. The tumor can be found between the premolars and the molars. The cause of this tumor is currently unknown but there has been new research that there is an overlap between gigantiform cementoma and Gnathodiaphyseal dysplasia (GDD).This is an exceedingly rare tumor with only a handful of documented cases worldwide. The most famous case is of Novemthree Siahaan, a young Indonesian boy from Batam Island who received medical care in Haulien, Taiwan through a Buddhist missionary from the Tzu Chi Foundation, which was documented on the Discovery Health Channel. Another famous case is a young Korean girl named Ayun Lee and her father Young-hak Lee whose case has shown that the tumor can be heritable. She is currently under treatment, which she may need to continue until her growth stops in her early 20s. Cases like Novemthree Siahann and Ayun Lee are included to illustrate the condition's worldwide and heritable nature. It is seen mostly in females with a mean age of 42 years old. The condition typically affects adults between the ages of 20 and 50, which there is a higher incidence in women compared to men. Although it can technically occur in both males and females, it is more frequent in females. There is a chance to get passed down but in recent research it is said that most cases are sporadic and not inherited. The term has been used in the past to describe florid cemento-osseous dysplasia, but it is now reserved for an autosomal dominant condition affecting the maxillae. There is still not enough research to confirm whether it predominately affects on specific group but it is a rare condition and it is not strictly associated with any one ethic group. Treatment is difficult. Surgical removal of the affected bone is needed, and has to be followed by reconstruction.

<span class="mw-page-title-main">Dentigerous cyst</span> Medical condition

A dentigerous cyst, also known as a follicular cyst, is an epithelial-lined developmental cyst formed by accumulation of fluid between the reduced enamel epithelium and the crown of an unerupted tooth. It is formed when there is an alteration in the reduced enamel epithelium and encloses the crown of an unerupted tooth at the cemento-enamel junction. Fluid is accumulated between reduced enamel epithelium and the crown of an unerupted tooth.

<span class="mw-page-title-main">Condensing osteitis</span> Hardening of tooth roots due to infection

Condensing osteitis, also known as focal sclerosing osteomyelitis, is a rare periapical inflammatory condition characterized by the formation of sclerotic bone near the roots of premolars and molars. This condition arises as a response to dental infections, such as periapical pulp inflammation or low-intensity trauma. The lesion typically appears as a radiopacity in the periapical area due to the sclerotic reaction. While most commonly associated with non-vital teeth, condensing osteitis can also occur in vital teeth following occlusal trauma. The condition was first described by Dr. Carl Garré in 1893.

Dens invaginatus (DI), also known as tooth within a tooth, is a rare dental malformation and a developmental anomaly where there is an infolding of enamel into dentin. The prevalence of this condition is 0.3 - 10%, affecting males more frequently than females. The condition presents in two forms, coronal involving tooth crown and radicular involving tooth root, with the former being more common.

<span class="mw-page-title-main">Dentin dysplasia</span> Medical condition

Dentin dysplasia (DD) is a rare genetic developmental disorder affecting dentine production of the teeth, commonly exhibiting an autosomal dominant inheritance that causes malformation of the root. It affects both primary and permanent dentitions in approximately 1 in every 100,000 patients. It is characterized by the presence of normal enamel but atypical dentin with abnormal pulpal morphology. Witkop in 1972 classified DD into two types which are Type I (DD-1) is the radicular type, and type II (DD-2) is the coronal type. DD-1 has been further divided into 4 different subtypes (DD-1a,1b,1c,1d) based on the radiographic features.

<span class="mw-page-title-main">Idiopathic osteosclerosis</span> Hardening of the teeth roots for an unknown reason

Idiopathic osteosclerosis, also known as enostosis or dense bone island, is a condition which may be found around the roots of a tooth, usually a premolar or molar. It is usually painless and found during routine radiographs as an amorphous radiopaque (light) area around a tooth. There is no sign of inflammation of the tooth, and if the island is associated with the root the periodontal ligament space is preserved.

<span class="mw-page-title-main">Periapical cyst</span> Sac growth at the root of a tooth

Commonly known as a dental cyst, the periapical cyst is the most common odontogenic cyst. It may develop rapidly from a periapical granuloma, as a consequence of untreated chronic periapical periodontitis.

<span class="mw-page-title-main">Odontogenic keratocyst</span> Medical condition

An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. It most often affects the posterior mandible and most commonly presents in the third decade of life. Odontogenic keratocysts make up around 19% of jaw cysts. Despite its more common appearance in the bone region, it can affect soft tissue.

Lateral periodontal cysts (LPCs) are defined as non-keratinised and non-inflammatory developmental cysts located adjacent or lateral to the root of a vital tooth.” LPCs are a rare form of jaw cysts, with the same histopathological characteristics as gingival cysts of adults (GCA). Hence LPCs are regarded as the intraosseous form of the extraosseous GCA. They are commonly found along the lateral periodontium or within the bone between the roots of vital teeth, around mandibular canines and premolars. Standish and Shafer reported the first well-documented case of LPCs in 1958, followed by Holder and Kunkel in the same year although it was called a periodontal cyst. Since then, there has been more than 270 well-documented cases of LPCs in literature.

<span class="mw-page-title-main">Dental abscess</span> Collection of pus in or around a tooth

A dental abscess is a localized collection of pus associated with a tooth. The most common type of dental abscess is a periapical abscess, and the second most common is a periodontal abscess. In a periapical abscess, usually the origin is a bacterial infection that has accumulated in the soft, often dead, pulp of the tooth. This can be caused by tooth decay, broken teeth or extensive periodontal disease. A failed root canal treatment may also create a similar abscess.

<span class="mw-page-title-main">Dental radiography</span> X-ray imaging in dentistry

Dental radiographs, commonly known as X-rays, are radiographs used to diagnose hidden dental structures, malignant or benign masses, bone loss, and cavities.

<span class="mw-page-title-main">Cementoma</span> Medical condition

Cementoma is an odontogenic tumor of cementum. It is usually observed as a benign spherical mass of hard tissue fused to the root of a tooth. It is found most commonly in the mandible in the region of the lower molar teeth, occurring between the ages of 8 and 30 in both sexes with equal frequency. It causes distortion of surrounding areas but is usually a painless growth, at least initially. Considerable thickening of the cementum can often be observed. A periapical form is also recognized. Cementoma is not exclusive to the mandible as it can infrequently occur in the maxilla and other parts of the body such as the long bones.

Pulp necrosis is a clinical diagnostic category indicating the death of cells and tissues in the pulp chamber of a tooth with or without bacterial invasion. It is often the result of many cases of dental trauma, caries and irreversible pulpitis.

Odontogenic cysts are a group of jaw cysts that are formed from tissues involved in odontogenesis. Odontogenic cysts are closed sacs, and have a distinct membrane derived from the rest of odontogenic epithelium. It may contain air, fluids, or semi-solid material. Intra-bony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial components. That odontogenic epithelium is critical in normal tooth development. However, epithelial rests may be the origin for the cyst lining later. Not all oral cysts are odontogenic cysts. For example, mucous cyst of the oral mucosa and nasolabial duct cyst are not of odontogenic origin.

Cysts of the jaws are cysts—pathological epithelial-lined cavities filled with fluid or soft material—occurring on the bones of the jaws, the mandible and maxilla. Those are the bones with the highest prevalence of cysts in the human body, due to the abundant amount of epithelial remnants that can be left in the bones of the jaws. The enamel of teeth is formed from ectoderm, and so remnants of epithelium can be left in the bone during odontogenesis. The bones of the jaws develop from embryologic processes which fuse, and ectodermal tissue may be trapped along the lines of this fusion. This "resting" epithelium is usually dormant or undergoes atrophy, but, when stimulated, may form a cyst. The reasons why resting epithelium may proliferate and undergo cystic transformation are generally unknown, but inflammation is thought to be a major factor. The high prevalence of tooth impactions and dental infections that occur in the bones of the jaws is also significant to explain why cysts are more common at these sites.

<span class="mw-page-title-main">Periapical periodontitis</span> Inflammation at the apex of a tooth root

Periapical periodontitis or apical periodontitis (AP) is an acute or chronic inflammatory lesion around the apex of a tooth root, most commonly caused by bacterial invasion of the pulp of the tooth. It is a likely outcome of untreated dental caries, and in such cases it can be considered a sequela in the natural history of tooth decay, irreversible pulpitis and pulpal necrosis. Other causes can include occlusal trauma due to 'high spots' after restoration work, extrusion from the tooth of root filling material, or bacterial invasion and infection from the gums. Periapical periodontitis may develop into a periapical abscess, where a collection of pus forms at the end of the root, the consequence of spread of infection from the tooth pulp, or into a periapical cyst, where an epithelial lined, fluid-filled structure forms.

Periapical granuloma, also sometimes referred to as a radicular granuloma or apical granuloma, is an inflammation at the tip of a dead (nonvital) tooth. It is a lesion or mass that typically starts out as an epithelial lined cyst, and undergoes an inward curvature that results in inflammation of granulation tissue at the root tips of a dead tooth. This is usually due to dental caries or a bacterial infection of the dental pulp. Periapical granuloma is an infrequent disorder that has an occurrence rate between 9.3 to 87.1 percent. Periapical granuloma is not a true granuloma due to the fact that it does not contain granulomatous inflammation; however, periapical granuloma is a common term used.

References

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  2. 1 2 Decolibus, Katherine; Shahrabi-Farahani, Shokoufeh; Brar, Anmol; Rasner, Shane D.; Aguirre, Sarah E.; Owosho, Adepitan A. (19 May 2023). "Cemento-Osseous Dysplasia of the Jaw: Demographic and Clinical Analysis of 191 New Cases". Dentistry Journal. 11 (5): 138.
  3. 1 2 3 4 5 6 7 8 9 Nam, Inhye; Ryu, Jihye; Shin, Sang-Hun; Kim, Yong-Deok; Lee, Jae-Yeol (30 April 2022). "Cemento-osseous dysplasia: clinical presentation and symptoms". Journal of the Korean Association of Oral and Maxillofacial Surgeons. 48 (2): 79–84.
  4. Farah, Camile S.; Matias, Marie Anne T. (December 2021). "Natural history of florid osseous dysplasia of the jaws with important clinical implications". Australian Endodontic Journal. 47 (3): 684–689.
  5. 1 2 Park, Sanghee; Jeon, Su-Jin; Yeom, Han-Gyeol; Seo, Min-Seock (11 April 2024). "Differential diagnosis of cemento-osseous dysplasia and periapical cyst using texture analysis of CBCT". BMC Oral Health. 24 (1).
  6. Günhan, Ömer; Kahraman, Devrim; Yalçın, Ülker Karagece (July 2021). "The possible pathogenesis of cemento-osseous dysplasia: A case series and discussion". Advances in Oral and Maxillofacial Surgery. 3: 100105.
  7. Alsufyani, Noura A.; Lam, Ernest W. N. (2011). "Osseous (cemento-osseous) dysplasia of the jaws: clinical and radiographic analysis". Journal (Canadian Dental Association). 77: b70. ISSN   1488-2159.
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