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Automated synthesis or automatic synthesis is a set of techniques that use robotic equipment to perform chemical synthesis in an automated way. Automating processes allows for higher efficiency and product quality although automation technology can be cost-prohibitive and there are concerns regarding overdependence and job displacement. Chemical processes were automated throughout the 19th and 20th centuries, with major developments happening in the previous thirty years, as technology advanced. Tasks that are performed may include: synthesis in variety of different conditions, sample preparation, purification, and extractions. Applications of automated synthesis are found on research and industrial scales in a wide variety of fields including polymers, personal care, and radiosynthesis.
Hans Bernhard "Berny" Schlegel is German-born computational and theoretical chemist, and distinguished professor at Wayne State University. He is a highly cited chemist, with a Thomson Reuters H-Index of 116 and citations of over 218,000 as of 2020. He is a professor of chemistry at the Wayne State University and co-author of the computational chemistry software, Gaussian. The "Berny optimization" as implemented in Gaussian is named after him. His group also created the Electronic Structure Perl Toolkit (ESPT).
References
- ↑ Merck KGaA to buy Chematica, by Andy Extance, at ChemistryWorld; published May 12, 2017; retrieved January 1, 2019
- ↑ Klucznik, Tomasz; Mikulak-Klucznik, Barbara; McCormack, Michael P.; Lima, Heather; Szymkuć, Sara; Bhowmick, Manishabrata; Molga, Karol; Zhou, Yubai; Rickershauser, Lindsey; Gajewska, Ewa P.; Toutchkine, Alexei (March 2018). "Efficient Syntheses of Diverse, Medicinally Relevant Targets Planned by Computer and Executed in the Laboratory". Chem. 4 (3): 522–532. doi: 10.1016/j.chempr.2018.02.002 . ISSN 2451-9294.
- ↑ Synthia
- ↑ Fellman, Megan. "Northwestern Scientists Create Chemical Brain". Northwestern University Press. Retrieved 25 August 2012.
- ↑ Grzybowski, Bartosz A.; Kyle J. M. Bishop; Mikołaj Kowalik; Chris M. Gothard; Aaron M. Drews; Nosheen A. Gothard; Alex Weckiewicz; Patrick E. Fuller (August 2012). "Parallel Optimization of Synthetic Pathways within the Network of Organic Chemistry". Angew. Chem. Int. Ed. 51 (32): 7928–7932. doi:10.1002/anie.201202209. PMID 22807100.
- 1 2 3 Chematica Demonstration. May 2012.Retrieved2013-04-09.