Cheryl Arrowsmith

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Cheryl Arrowsmith
Born1959 (age 65–66)
Hackensack, New Jersey
EducationBSc, Allegheny College
PhD, chemistry, 1987, University of Toronto
Scientific career
Fields Structural biology
Institutions Structural Genomics Consortium
Thesis Two studies in physical organic chemistry: bifunctional catalysis of the decomposition of the nitramide anion: hydrogen isotope effects on carbon-13 NMR chemical shifts  (1987)
Website nmr.uhnres.utoronto.ca/arrowsmith/

Cheryl Hillock Arrowsmith FRSC (born 1959) [1] is an American-Canadian structural biologist. She is the Chief Scientist at the Toronto laboratory of the Structural Genomics Consortium. Her contributions to protein structural biology includes the use of NMR and X-ray crystallography to pursue structures of proteins on a proteome wide scale.

Contents

Early life and education

Arrowsmith was born in 1959 in Hackensack, New Jersey. She completed her Bachelor of Science degree at Allegheny College and her PhD in chemistry at the University of Toronto in 1987. [2] While completing her PhD, Arrowsmith became interested in tumour suppressor p53 and related proteins after taking a course in nuclear magnetic resonance (NMR). This motivated her to complete her postdoctoral studies at Stanford University with Oleg Jardetzky in his Magnetic Resonance Lab. [3]

Career

Her current research is to determine the 3-dimensional structures of human proteins of therapeutic relevance by structural proteomics. [4] She has made significant contributions to epigenetic signaling in the context of drug discovery. [5]

Arrowsmith was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2015. [6] She was also named as one of the Clarivate Highly Cited Researchers in 2023. [7] In 2020, she was elected a Fellow of the Royal Society of Canada. [8]

References

  1. ↑ "Arrowsmith, Cheryl Hillock, 1959-". VIAF. Retrieved April 16, 2025.
  2. ↑ "Cheryl Arrowsmith". Governorment of Canada. December 13, 2021. Archived from the original on June 16, 2024. Retrieved April 16, 2025.
  3. ↑ "Meet Cheryl Arrowsmith @PMResearch". University Health Network. July 26, 2023. Retrieved April 16, 2025.
  4. ↑ Chandonia JM, Brenner SE (January 2006). "The impact of structural genomics: expectations and outcomes". Science. 311 (5759): 347–51. Bibcode:2006Sci...311..347C. doi:10.1126/science.1121018. OSTI   891629. PMID   16424331. S2CID   800902.
  5. ↑ Cheryl H. Arrowsmith, Chas Bountra, Paul V. Fish, Kevin Lee & Matthieu Schapira. Epigenetic protein families: a new frontier for drug discovery. Nature Reviews Drug Discovery 11, 384–400 (2012)
  6. ↑ Morris, Carolyn (November 23, 2015). "Arrowsmith Named AAAS Fellow". University of Toronto. Retrieved April 17, 2025.
  7. ↑ "Clarivate Reveals World's Influential Researchers in Highly Cited Researchers 2023 List". Clarivate. November 15, 2023. Retrieved April 17, 2025.
  8. ↑ "Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the Royal Society of Canada". Structural Genomics Consortium. October 9, 2020. Retrieved April 16, 2025.
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