Chronic allograft nephropathy

Chronic allograft nephropathy
Other names	Sclerosing/chronic allograft nephropathy
Micrograph of chronic allograft nephropathy. PAS stain.
Specialty	Urology

Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure, ^[1] occurring months to years after the transplant.

Symptoms and signs

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria. ^[2]

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis. ^{[2] [3]}

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy. ^[4]

References

1. Paul, LC. (Sep 1999). "Chronic allograft nephropathy: An update". Kidney Int. 56 (3): 783–93. doi: 10.1046/j.1523-1755.1999.00611.x . PMID   10469349.
2. Joosten, SA.; Sijpkens, YW.; van Kooten, C.; Paul, LC. (Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations". Kidney Int. 68 (1): 1–13. doi: 10.1111/j.1523-1755.2005.00376.x . PMID   15954891.
3. Nankivell, BJ.; Chapman, JR. (Mar 2006). "Chronic allograft nephropathy: current concepts and future directions". Transplantation. 81 (5): 643–54. doi: 10.1097/01.tp.0000190423.82154.01 . PMID   16534463. S2CID   30085431.
4. Fletcher, Jeffery T.; Nankivell, Brian J.; Alexander, Stephen I. (2009). "Chronic allograft nephropathy". Pediatric Nephrology. 24 (8). Springer Science and Business Media LLC: 1465–1471. doi:10.1007/s00467-008-0869-z. ISSN   0931-041X. PMC   2697362 . PMID   18584214.