Clemens van Blitterswijk

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Clemens van Blitterswijk
VanBlitterswijk.JPG
Clemens van Blitterswijk
Born1957 (age 67–68)
The Hague, Netherlands
NationalityDutch
Alma mater University of Leiden
AwardsJean Leray Award;

The Marie Parijs Award; The Klein Award;

George Winter Award; Huibregtsen Prize; Career Achievement Award;
Scientific career
Fields Biomedical engineering, biomaterials, tissue engineering
Institutions University of Maastricht

Clemens A. van Blitterswijk (1957, The Hague) is a Dutch tissue engineer who contributed to the use of biomaterials to heal bone injuries, especially using osteoinductive ceramics. [1] [2] In collaboration with Jan de Boer and others, he has contributed to screening microtextures to study cell-biomaterial interactions, an approach termed materiomics.

Contents

Career

Blitterswijk graduated from a bachelor in cell biology at Leiden University and defended his PhD thesis in 1985 at the same university on artificial ceramic middle ear implants under the supervision of Professor Jan Grote [3] and Klaas de Groot, [4] for which he was awarded the Jean Leray young scientist award from the European Society for Biomaterials in 1987. [5] From 1985 to 1996, he worked on hydroxyapatite biomaterials for middle ear implants under the mentorship of Jan Grote [6] [7] [8] and Klaas De Groot [9] [10] at Leiden University.

In 1996, he left Leiden University and co-founded, together with Klaas De Groot, IsoTis BV, a life sciences company focused on bone biomaterials and tissue engineering.

In 1997, he became a professor at University of Twente. Later, he was appointed director of the University of Twente's MIRA Institute for Biomedical Technology and Technical Medicine institute (the institute no longer exists). In collaboration with Jan de Boer, Hemant Unadkat, and Dimitrios Stamatialis, he contributed to the development of a high-throughput assay to design and select micrometer-scale surface textures that could enhance specific biological functions (TopoChip). [11] [12]

In 2012, he became a partner of the Life Science Partner (LSP) private investment firm where he invests in private companies and startups related to healthcare innovations. [13]

In 2014, he became a distinguished professor at Maastricht University. [14] Until 2018, he was the director and department chair at the MERLN Institute at Maastricht University. In 2015, he was awarded an ERC Advanced grant that aimed at developing microfabricated and microfluidic cell culture platforms for improving organoids. [15] The conception of this grant application and the research relative to it were done by several principal investigators at Maastricht University. [16] [17] [18] [19] [20] [21]

Valorization

He has served as CEO of IsoTis., [22] a company that underwent an Initial Public Offering and was subsequently acquired by Integra LifeSciences. [23] [24] In 2018, he became the chairman of the board of directors of Kuros Biosciences. [25]

Teaching

Blitterswijk has been the official supervisor of over 80 PhD candidates who, in their large majority, have worked in the laboratories of other faculty members. He has participated as an editor of four textbooks, including one dedicated to tissue engineering. [26]

Awards

Ten outstanding publications as a co-author or corresponding author

References

  1. ↑ Miron, R.J.; Zhang, Y.F. (August 2012). "Osteoinduction: A Review of Old Concepts with New Standards". Journal of Dental Research. 91 (8): 736–744. doi:10.1177/0022034511435260. ISSN   0022-0345. PMID   22318372. S2CID   209326442.
  2. ↑ Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. Bibcode:2010PNAS..10713614Y. doi: 10.1073/pnas.1003600107 . PMC   2922269 . PMID   20643969.
  3. ↑ Van Blitterswijk, C. A.; Kuijpers, W.; Daems, W Th; Grote, J. J. (January 1986). "Epithelial Reactions to Hydroxyapatite: An in Vivo and in Vitro Study". Acta Oto-Laryngologica. 101 (3–4): 231–241. doi:10.3109/00016488609132832. ISSN   0001-6489. PMID   3705952.
  4. ↑ van Blitterswijk, C.A.; Grote, J.J.; Kuijpers, W.; Daems, W.Th.; de Groot, K. (March 1986). "Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic". Biomaterials. 7 (2): 137–143. doi:10.1016/0142-9612(86)90071-2. ISSN   0142-9612. PMID   3011138.
  5. 1 2 "ESB European Society for Biomaterials". www.esbiomaterials.eu. Archived from the original on 8 November 2021. Retrieved 1 June 2020.
  6. ↑ Nell, M.J.; Op't Hof, B.M.; Koerten, H.K.; Grote, J.J. (1999). "Effect of Endotoxin on Cultured Human Middle Ear Epithelium". ORL. 61 (4): 201–205. doi:10.1159/000027671. ISSN   0301-1569. PMID   10450054. S2CID   20788406.
  7. ↑ Bakker, D.; van Blitterswijk, C. A.; Hesseling, S. C.; Th. Daems, W.; Kuijpers, W.; Grote, J. J. (June 1990). "The behavior of alloplastic tympanic membranes inStaphylococcus aureus-induced middle ear infection. I. Quantitative biocompatibility evaluation". Journal of Biomedical Materials Research. 24 (6): 669–688. doi:10.1002/jbm.820240604. ISSN   0021-9304. PMID   2163404.
  8. ↑ Jj, Grote; D, Bakker; Sc, Hesseling; Ca, van Blitterswijk (September 1991). "New Alloplastic Tympanic Membrane Material". The American Journal of Otology. 12 (5): 329–35. PMID   1665011.
  9. ↑ van Blitterswijk, C. A.; Hesseling, S. C.; Grote, J. J.; Koerten, H. K.; de Groot, K. (April 1990). "The biocompatibility of hydroxyapatite ceramic: A study of retrieved human middle ear implants". Journal of Biomedical Materials Research. 24 (4): 433–453. doi:10.1002/jbm.820240403. ISSN   0021-9304. PMID   2161412.
  10. ↑ Verheyen, C. C. P. M.; De Wijn, J. R.; Van Blitterswijk, C. A.; De Groot, K. (October 1992). "Evaluation of hydroxylapatite/poly(l-lactide) composites: Mechanical behavior". Journal of Biomedical Materials Research. 26 (10): 1277–1296. doi:10.1002/jbm.820261003. ISSN   0021-9304. PMID   1331112.
  11. ↑ Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. Bibcode:2011PNAS..10816565U. doi: 10.1073/pnas.1109861108 . PMC   3189082 . PMID   21949368.
  12. ↑ Baker M (November 2011). "Trying out topographies" (PDF). Nature Methods. 8 (11): 900. doi: 10.1038/nmeth.1760 . PMID   22167818. S2CID   5421979.
  13. ↑ "LSP van Blitterswijk".
  14. ↑ "Distinguished university professors – Research – Maastricht University". maastrichtuniversity.nl. Retrieved 1 February 2018.
  15. ↑ "Press release Maastricht University". Maastricht University. 8 April 2016.
  16. ↑ Geuens, Thomas; van Blitterswijk, Clemens A.; LaPointe, Vanessa L. S. (30 April 2020). "Overcoming kidney organoid challenges for regenerative medicine". npj Regenerative Medicine. 5 (1): 8. doi: 10.1038/s41536-020-0093-4 . ISSN   2057-3995. PMC   7192889 . PMID   32377381.
  17. ↑ Samal, Pinak; Maurer, Philipp; Blitterswijk, Clemens; Truckenmüller, Roman; Giselbrecht, Stefan (29 April 2020). "A New Microengineered Platform for 4D Tracking of Single Cells in a Stem‐Cell‐Based In Vitro Morphogenesis Model". Advanced Materials. 32 (24): 1907966. Bibcode:2020AdM....3207966S. doi: 10.1002/adma.201907966 . ISSN   0935-9648. PMID   32346909.
  18. ↑ Kuhnt, Tobias; Marroquín García, Ramiro; Camarero-Espinosa, Sandra; Dias, Aylvin; ten Cate, A. Tessa; van Blitterswijk, Clemens A.; Moroni, Lorenzo; Baker, Matthew B. (2019). "Poly(caprolactone- co -trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants". Biomaterials Science. 7 (12): 4984–4989. doi: 10.1039/C9BM01042D . ISSN   2047-4830. PMID   31667486.
  19. ↑ Sthijns, Mireille M.J.P.E.; LaPointe, Vanessa L.S.; van Blitterswijk, Clemens A. (1 October 2019). "Building Complex Life Through Self-Organization". Tissue Engineering Part A. 25 (19–20): 1341–1346. doi:10.1089/ten.tea.2019.0208. ISSN   1937-3341. PMC   6784492 . PMID   31411111.
  20. ↑ Rademakers, Timo; Horvath, Judith M.; Blitterswijk, Clemens A.; LaPointe, Vanessa L.S. (October 2019). "Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization". Journal of Tissue Engineering and Regenerative Medicine. 13 (10): 1815–1829. doi:10.1002/term.2932. ISSN   1932-6254. PMC   6852121 . PMID   31310055.
  21. ↑ Ooi, Huey Wen; Mota, Carlos; Ten Cate, A. Tessa; Calore, Andrea; Moroni, Lorenzo; Baker, Matthew B. (25 June 2018). "ThiolEne Alginate Hydrogels as Versatile Bioinks for Bioprinting". Biomacromolecules. 19 (8): 3390–3400. doi:10.1021/acs.biomac.8b00696.s001. PMC   6588269 . PMID   29939754.
  22. ↑ "IsoTis Orthobiologics Archives". SeaSpine.
  23. ↑ "IsoTis – Integra Merger" . Retrieved 30 September 2018.
  24. ↑ "UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934" . Retrieved 30 September 2018.
  25. ↑ "Professor Clemens van Blitterswijk". Kuros Biosciences. Retrieved 24 May 2020.
  26. ↑ Van Blitterswijk, Clemens A.; Thomsen, Peter (2008). Tissue Engineering. Academic. ISBN   978-0123708694.
  27. ↑ "ESB European Society for Biomaterials". esbiomaterials.eu. Archived from the original on 8 November 2021. Retrieved 1 February 2018.
  28. ↑ "Federaprijs-winnaars – Federa". federa.org.
  29. ↑ "News_van Blitterswijk most entrepreneurial scientist in 2012" . Retrieved 1 February 2018.
  30. ↑ "TERMIS". Archived from the original on 7 July 2017. Retrieved 1 February 2018.
  31. ↑ "Over de prijs". avondwenm.nl.
  32. ↑ "ESB European Society for Biomaterials". www.esbiomaterials.eu. Retrieved 15 November 2021.
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