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Other names | HSK7653 |
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Formula | C18H19F5N4O3S |
Molar mass | 466.43 g·mol−1 |
Cofrogliptin (developmental name HSK7653) is a long-acting DPP4 inhibitor dosed once every two weeks. [1] [2] [3] [4]
Huperzine A is a naturally-occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata and in varying quantities in other food Huperzia species, including H. elmeri, H. carinat, and H. aqualupian. Huperzine A has been investigated as a treatment for neurological conditions such as Alzheimer's disease, but a 2013 meta-analysis of those studies concluded that they were of poor methodological quality and the findings should be interpreted with caution. Huperzine A inhibits the breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase. It is commonly available over the counter as a nutritional supplement and marketed as a memory and concentration enhancer.
The China men's national basketball team represents the People's Republic of China in international basketball tournaments. The national team is governed by the Chinese Basketball Association (CBA). Based on the number of tournament titles, China is considered a major basketball powerhouse in Asia and has by far the most successful basketball program on the continent.
Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus, Leonotis nepetifolia, Leonurus japonicus, Leonurus cardiaca (motherwort), Leonurus sibiricus, as well as other plants of family Lamiaceae. Leonurine is easily extracted into water.
Justice Bao is a Chinese TV series starring producer Jin Chao-chun as the Song dynasty official Bao Zheng. The series ran for 3 seasons from 2010 to 2012. In addition to Jin, Kenny Ho, Fan Hung-hsuan and Lung Lung again reprise their iconic roles from the 1993 Taiwanese hit Justice Pao and the 2008 Chinese series Justice Bao.
Zhuge Liang is a Chinese television series based on the life of Zhuge Liang, a chancellor of the state of Shu Han in the Three Kingdoms period. The plot is based on stories about Zhuge Liang in the 14th-century historical novel Romance of the Three Kingdoms. The series starred Li Fazeng as the title character and was first aired on Hubei TV in mainland China in 1985. The show has been applauded for its historically accurate sets and costumes.
The Investiture of the Gods is a 1990 Chinese shenmo television series written by Bing Tian, Gu Hanchang, Ouyang Yuping and Yu Youchen. The television series are based on the classical 16th-century novel Fengshen Yanyi written by Xu Zhonglin and Lu Xixing.
Geniposide, the glycoside form of genipin, is a bioactive iridoid glycoside that is found in a wide variety of medicinal herbs, such as Gardenia jasminoides (fruits) . Geniposide shows several pharmacological effects including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic and antitumoral activity. These pharmacology benefits arise through the modulating action of geniposide on several proteins and genes that are associated with inflammatory and oxidative stress processes.
Ciprofol is a novel 2,6-disubstituted phenol derivative that is used for the intravenous induction of general anesthesia. A short-acting and highly selective γ-aminobutyric acid agonist, ciprofol is 4–6 times more potent than other phenol derivatives such as propofol or fospropofol.
Crisugabalin (HSK16149) is a selective GABA analog in development for the treatment of chronic pain. It has a wider therapeutic index than pregabalin, which as a similar mechanism of action. It is in Phase III trials as of 2023. The drug can be administered with or without food.
Fotagliptin (SAL067) is a DPP-4 inhibitor under development for the treatment of type 2 diabetes. Like other DPP-4 inhibitors, it works by increasing endogenously produced GLP-1 and GIP. In a phase 3 trial it showed similar results as alogliptin.
Mazdutide is a dual agonist of the GLP-1 receptor and glucagon receptor. It is an analog of oxyntomodulin (OXM). The drug is developed by Eli Lilly and is currently in a Phase II study.
Ivarmacitinib (SHR0302) is a small molecule drug and selective janus kinase 1 (JAK1) inhibitor. It is being developed for ulcerative colitis, eczema, alopecia areata, and graft-versus-host disease.
Ruzinurad (SHR4640) is a selective urate transporter 1 (URAT1) inhibitor in development for hyperuricaemia and gout. It is developed by Jiangsu Hengrui.
Famitinib is a tyrosine kinase receptor inhibitor developed by Jiangsu Hengrui for a variety of cancers.
Prusogliptin (DBPR108) is an experimental DPP-4 inhibitor developed by CSPC Pharmaceutical Group to treat type 2 diabetes.
Globalagliatin (SY-004) is a glucokinase activator developed by Yabao Pharmaceutical Group for type 2 diabetes.
Janagliflozin is an experimental SGLT2 inhibitor developed by Sihuan Pharmaceutical.
Azeliragon is a small-molecule RAGE inhibitor. It is developed by vTv Therapeutics for various cancers, including triple-negative breast cancer, pancreatic cancer.
ZSP1601 is an experimental pan-phosphodiesterase inhibitor developed by Guangdong Raynovent Biotech for nonalcoholic steatohepatitis.