Cortagen

Cortagen

Identifiers
IUPAC name (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carboxylic acid
PubChem CID	18439621
ChemSpider	16364972
Chemical and physical data
Formula	C17H26N4O9
Molar mass	430.414 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)O)N
InChI InChI=1S/C17H26N4O9/c1-8(18)14(26)19-9(4-5-12(22)23)15(27)20-10(7-13(24)25)16(28)21-6-2-3-11(21)17(29)30/h8-11H,2-7,18H2,1H3,(H,19,26)(H,20,27)(H,22,23)(H,24,25)(H,29,30)/t8-,9-,10-,11-/m0/s1 Key:PLTRIMAUDDQYRV-NAKRPEOUSA-N

Cortagen is a tetrapeptide with the sequence AEDP or Ala-Glu-Asp-Pro. It was originally identified as a primary active component of Cortexin, a mixture of peptides derived from cow brain cortex tissue. It is claimed to stimulate nerve growth and enhance repair of damaged nerves. ^{[1] [2] [3] [4]}

See also

• Epitalon
• GHK-Cu
• KPV tripeptide
• Livagen
• Pinealon

References

1. Turchaninova LN, Kolosova LI, Malinin VV, Moiseeva AB, Nozdrachev AD, Khavinson VK (December 2000). "Effect of tetrapeptide cortagen on regeneration of sciatic nerve". Bulletin of Experimental Biology and Medicine. 130 (12): 1172–1174. doi:10.1023/A:1017532001908. PMID   11276314.
2. Anisimov SV, Khavinson VK, Anisimov VN (2004). "Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray". Neuro Endocrinology Letters. 25 (1–2): 87–93. PMID   15159690.
3. Zarubina IV, Shabanov PD (2011). "[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia]". Eksperimental'naia i Klinicheskaia Farmakologiia. 74 (2): 8–15. PMID   21476278.
4. Zarubina IV, Shabanov PD (February 2016). "Neuroprotective Effects of Peptides during Ischemic Preconditioning". Bulletin of Experimental Biology and Medicine. 160 (4): 448–451. doi:10.1007/s10517-016-3193-9. PMID   26902350.