Cychlorphine

Last updated

Cychlorphine
Cychlorphine structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C23H25ClN4O
Molar mass 408.93 g·mol−1
3D model (JSmol)
  • CC(C1=CC=C(C=C1)Cl)N2CCC(CC2)N3C4=CC=CC=C4N(C3=O)CCC#N
  • InChI=1S/C23H25ClN4O/c1-17(18-7-9-19(24)10-8-18)26-15-11-20(12-16-26)28-22-6-3-2-5-21(22)27(23(28)29)14-4-13-25/h2-3,5-10,17,20H,4,11-12,14-16H2,1H3
  • Key:SWWAVNFEFVMDAG-UHFFFAOYSA-N

Cychlorphine (N-Propionitrile chlorphine) is a chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA. [1] It has been found in Canada as of September 2025. [2] It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published. [3] [4] [5]

At least 5 people have died from a cychlorphine overdose in England in 2025. [6] Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses. [2]

See also

References

  1. ↑ Sprague JE, Toms JA, Ratermann CF. Non-fatal opioid overdose associated predominantly with the benzimidazolone, cychlorphine. Clin Toxicol (Phila). 2025 Dec 5:1-2. doi : 10.1080/15563650.2025.2594070 PMID   41347459
  2. 1 2 Alevato J (November 4, 2025). "A new opioid has been found in Toronto's drug supply and users may not even know it". CBC.ca . Retrieved December 7, 2025.
  3. ↑ "Chlorphine" (PDF). NPS Discovery — New Drug Monograph. The Center for Forensic Science Research & Education (CSFRE).
  4. ↑ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
  5. ↑ US 3318900,Janssen PA,"Derivatives of benzimidazolinyl piperidine",issued 9 May 1967, assigned to Janssen Pharmaceutica NV
  6. ↑ Barradale G (December 5, 2025). "Warning over new opioid 200 times stronger than heroin as three dead within days". The Big Issue . Retrieved December 7, 2025.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.