DDT (gene)

DDT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT , DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750 MGI: 1298381 HomoloGene: 1038 GeneCards: DDT
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,979,828 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,609,248 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; kidney; ; body of stomach; ; left ventricle; ; fundus; ; right adrenal gland; ; duodenum; ; left adrenal gland; ; substantia nigra;
	Top expressed in
	proximal tubule; ; spermatocyte; ; yolk sac; ; kidney; ; testicle; ; white adipose tissue; ; liver; ; adrenal gland; ; pancreas; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopachrome isomerase activity ; D-dopachrome decarboxylase activity ; lyase activity ; cytokine receptor binding ; phenylpyruvate tautomerase activity ;
Cellular component	cytoplasm ; extracellular exosome ; extracellular space ;
Biological process	melanin biosynthetic process ; negative regulation of macrophage chemotaxis ; positive regulation of tumor necrosis factor production ; positive regulation of inflammatory response ; positive regulation of ERK1 and ERK2 cascade ;
	Sources:Amigo / QuickGO
Orthologs
	1652
	13202
	ENSG00000099977 ; ENSG00000275003
	ENSMUSG00000001666
	P30046
	O35215
	NM_001084392 ; NM_001355 ; NM_001381852 ; NM_001397485
	NM_010027
	NP_001077861 ; NP_001346 ; NP_001368781
	NP_034157
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.^[5]^[6]^[7]

Related Research Articles

Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. MIF is an important regulator of innate immunity. The MIF protein superfamily also includes a second member with functionally related properties, the D-dopachrome tautomerase (D-DT). CD74 is a surface receptor for MIF.

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74, is a protein that in humans is encoded by the CD74 gene. The invariant chain is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. The cell surface form of the invariant chain is known as CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF).

In enzymology, a L-dopachrome isomerase is an enzyme that catalyzes the chemical reaction

The enzyme D-dopachrome decarboxylase (EC 4.1.1.84) catalyzes the chemical reaction

Dopachrome tautomerase , also known as DCT, is a human gene. Its expression is regulated by the microphthalmia-associated transcription factor (MITF).

Alpha-N-acetylgalactosaminidase is an enzyme that in humans is encoded by the NAGA gene.

Protein unc-84 homolog B is a protein that in humans is encoded by the UNC84B gene.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.

Macrophage migration inhibitory factor domain is an evolutionary conserved protein domain.

References

1 2 3 ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
↑ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731 . PMID 9729470.
1 2 "Entrez Gene: DDT D-dopachrome tautomerase".

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Odh G, Hindemith A, Rosengren AM, et al. (1994). "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole". Biochem. Biophys. Res. Commun. 197 (2): 619–24. doi:10.1006/bbrc.1993.2524. PMID 8267597.
Esumi N, Budarf M, Ciccarelli L, et al. (1999). "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF". Mamm. Genome. 9 (9): 753–7. doi:10.1007/s003359900858. PMID 9716662. S2CID 24034990.
Sugimoto H, Taniguchi M, Nakagawa A, et al. (1999). "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution". Biochemistry. 38 (11): 3268–79. doi:10.1021/bi982184o. PMID 10079069.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Lubetsky JB, Dios A, Han J, et al. (2002). "The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents". J. Biol. Chem. 277 (28): 24976–82. doi: 10.1074/jbc.M203220200 . PMID 11997397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Sonesson B, Rosengren E, Hansson AS, Hansson C (2004). "UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor". Exp. Dermatol. 12 (3): 278–82. doi:10.1034/j.1600-0625.2003.120307.x. PMID 12823441. S2CID 12494872.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480844-5] Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.

[pmid9729470-6] Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731 . PMID 9729470.

[entrez-7] 1 2 "Entrez Gene: DDT D-dopachrome tautomerase".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

DDT (gene)

Contents

See also

Related Research Articles

References

Further reading