DDT (gene)

DDT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT , DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750; MGI: 1298381; HomoloGene: 1038; GeneCards: DDT; OMA:DDT - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.23 Start 23,971,365 bp [1] End 23,979,828 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 38.58 cM Start 75,607,064 bp [2] End 75,609,248 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of transverse colon body of pancreas human kidney apex of heart body of stomach left ventricle fundus olfactory zone of nasal mucosa right adrenal gland Top expressed in right kidney proximal tubule spermatocyte yolk sac human kidney embryo testicle white adipose tissue epiblast liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dopachrome isomerase activity D-dopachrome decarboxylase activity lyase activity cytokine receptor binding phenylpyruvate tautomerase activity Cellular component cytoplasm extracellular exosome extracellular space Biological process melanin biosynthetic process negative regulation of macrophage chemotaxis positive regulation of tumor necrosis factor production positive regulation of inflammatory response positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1652 13202 Ensembl ENSG00000099977 ENSG00000275003 ENSMUSG00000001666 UniProt P30046 O35215 RefSeq (mRNA) NM_001084392 NM_001355 NM_001381852 NM_001397485 NM_010027 RefSeq (protein) NP_001077861 NP_001346 NP_001368781 NP_034157 Location (UCSC) Chr 22: 23.97 – 23.98 Mb Chr 10: 75.61 – 75.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene. ^{[5] [6] [7]}

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. ^[7]

See also

• Macrophage migration inhibitory factor domain

References

1. ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001666 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID   9480844.
6. Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC   1219731 . PMID   9729470.
7. "Entrez Gene: DDT D-dopachrome tautomerase".

Further reading

• Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID   1286669. S2CID   23518983.
• Odh G, Hindemith A, Rosengren AM, et al. (1994). "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole". Biochem. Biophys. Res. Commun. 197 (2): 619–24. doi:10.1006/bbrc.1993.2524. PMID   8267597.
• Esumi N, Budarf M, Ciccarelli L, et al. (1999). "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF". Mamm. Genome. 9 (9): 753–7. doi:10.1007/s003359900858. PMID   9716662. S2CID   24034990.
• Sugimoto H, Taniguchi M, Nakagawa A, et al. (1999). "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution". Biochemistry. 38 (11): 3268–79. doi:10.1021/bi982184o. PMID   10079069.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Lubetsky JB, Dios A, Han J, et al. (2002). "The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents". J. Biol. Chem. 277 (28): 24976–82. doi: 10.1074/jbc.M203220200 . PMID   11997397.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Sonesson B, Rosengren E, Hansson AS, Hansson C (2004). "UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor". Exp. Dermatol. 12 (3): 278–82. doi:10.1034/j.1600-0625.2003.120307.x. PMID   12823441. S2CID   12494872.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.