DDX31

DDX31
Identifiers
Aliases	DDX31 , PPP1R25, DEAD-box helicase 31
External IDs	OMIM: 616533 MGI: 2682639 HomoloGene: 6389 GeneCards: DDX31
Gene location (Human)
Chr.	Chromosome 9 (human)
End	132,670,401 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,795,583 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; cerebellar hemisphere; ; islet of Langerhans; ; skin of abdomen; ; tibial nerve; ; sural nerve; ; right lobe of liver; ; body of pancreas; ; gastrocnemius muscle;
	Top expressed in
	Paneth cell; ; condyle; ; primitive streak; ; fossa; ; medullary collecting duct; ; aortic valve; ; morula; ; renal corpuscle; ; supraoptic nucleus; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; protein binding ; hydrolase activity ; ATP binding ; helicase activity ; nucleic acid binding ; RNA binding ;
Cellular component	Golgi apparatus ; intracellular membrane-bounded organelle ; nucleus ; nucleolus ; cytoplasm ;
Biological process	ribosome biogenesis ; RNA secondary structure unwinding ;
	Sources:Amigo / QuickGO
Orthologs
	64794
	227674
	ENSG00000125485
	ENSMUSG00000026806
	Q9H8H2
	Q6NZQ2
NM_022779 ; NM_138620 ; NM_001322340 ; NM_001322341 ; NM_001322342 ;
	NM_001322343 ; NM_001322344
	NM_001033294
NP_001309269 ; NP_001309270 ; NP_001309271 ; NP_001309272 ; NP_001309273 ;
	NP_073616 ; NP_619526
	NP_001028466
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31, also known as DDX31, is a human gene.^[5]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants.^[5]

Related Research Articles

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.

ATP-dependent RNA helicase DDX24 is an enzyme that in humans is encoded by the DDX24 gene.

ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.

Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene.

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene.

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.

Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene.

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

<span class="mw-page-title-main">DDX50</span>

ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene.

Probable ATP-dependent RNA helicase DDX52 is an enzyme that in humans is encoded by the DDX52 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene.

Probable ATP-dependent RNA helicase DDX59 is an enzyme that in humans is encoded by the DDX59 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125485 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026806 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Abdelhaleem M, Maltais L, Wain H (2004). "The human DDX and DHX gene families of putative RNA helicases". Genomics. 81 (6): 618–22. doi:10.1016/S0888-7543(03)00049-1. PMID 12782131.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000125485 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026806 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31".

[1]

[2]

[3]

[4]

[5]

DDX31

Related Research Articles

References

Further reading