DDX53

DDX53
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3IUY
Identifiers
Aliases	DDX53 , CAGE, CT26, DEAD-box helicase 53
External IDs	HomoloGene: 85175; GeneCards: DDX53; OMA:DDX53 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	23,003,589 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; sperm; ; right testis; ; left testis; ; human musculoskeletal system; ; muscular system; ; skeletal muscle; ; lower limb muscles; ; muscle of leg;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding ; hydrolase activity ; nucleotide binding ; nucleic acid binding ; helicase activity ; RNA binding ;
Cellular component	nucleus ; nucleolus ; cytoplasm ;
Biological process	RNA secondary structure unwinding ;
	Sources:Amigo / QuickGO
Orthologs
	168400
	n/a
	ENSG00000184735
	n/a
	Q86TM3
	n/a
	NM_182699
	n/a
	NP_874358
	n/a
	Wikidata
View/Edit Human

Last updated December 20, 2024

DEAD-box helicase 53 is a protein that in humans is encoded by the DDX53 gene. ^[3]

Function

This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. In 2024 it was found that varients of DDX53 is linked to Autism ^[4]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184735 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: DEAD-box helicase 53" . Retrieved 2017-08-18.
↑ genetic-discovery-reveals-direct-link-to-autism-key-player

Cho B, Lim Y, Lee DY, Park SY, Lee H, Kim WH, Yang H, Bang YJ, Jeoung DI (2002). "Identification and characterization of a novel cancer/testis antigen gene CAGE". Biochem. Biophys. Res. Commun. 292 (3): 715–26. doi:10.1006/bbrc.2002.6701. PMID 11922625.
Cho B, Lee H, Jeong S, Bang YJ, Lee HJ, Hwang KS, Kim HY, Lee YS, Kang GH, Jeoung DI (2003). "Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma". Biochem. Biophys. Res. Commun. 307 (1): 52–63. doi:10.1016/s0006-291x(03)01121-5. PMID 12849980.
Shim H, Lee H, Jeoung D (2006). "Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK)". Biotechnol. Lett. 28 (24): 2057–63. doi:10.1007/s10529-006-9190-8. PMID 17028776. S2CID 7168043.
Lee TS, Kim JW, Kang GH, Park NH, Song YS, Kang SB, Lee HP (2006). "DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix". Ann. N. Y. Acad. Sci. 1091 (1): 218–24. Bibcode:2006NYASA1091..218L. doi:10.1196/annals.1378.068. PMID 17341616. S2CID 28013856.
Kim Y, Jeoung D (2008). "Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility". J. Microbiol. Biotechnol. 18 (3): 600–10. PMID 18388483.
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Kim Y, Park H, Park D, Lee YS, Choe J, Hahn JH, Lee H, Kim YM, Jeoung D (2010). "Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs". J. Biol. Chem. 285 (34): 25957–68. doi: 10.1074/jbc.M109.095950 . PMC 2923988 . PMID 20534591.
Kim Y, Kim H, Park D, Han M, Lee H, Lee YS, Choe J, Kim YM, Jeoung D (2016). "miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2". Oncotarget. 7 (9): 10297–321. doi:10.18632/oncotarget.7185. PMC 4891121 . PMID 26863629.
Kim H, Kim Y, Goh H, Jeoung D (2016). "Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs". Mol. Cells. 39 (3): 229–41. doi:10.14348/molcells.2016.2244. PMC 4794605 . PMID 26883907.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184735 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: DEAD-box helicase 53" . Retrieved 2017-08-18.

[4] tic-discovery-reveals-direct-link-to-autism-key-player

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[4]

DDX53

Contents

Function

Related Research Articles

References

Further reading