DEC1

DELEC1
Identifiers
Aliases	DELEC1 , CTS9, deleted in esophageal cancer 1, DEC1
External IDs	OMIM: 604767; GeneCards: DELEC1; OMA:DELEC1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.1 Start 114,850,968 bp [1] End 115,402,644 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad granulocyte monocyte Achilles tendon sural nerve popliteal artery tibial arteries smooth muscle tissue stromal cell of endometrium n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 50514 n/a Ensembl ENSG00000173077 n/a UniProt Q9P2X7 n/a RefSeq (mRNA) NM_017418 n/a RefSeq (protein) NP_059114 n/a Location (UCSC) Chr 9: 114.85 – 115.4 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene. ^{[3] [4] [5]}

Function

The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000173077 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res. 56 (7): 1629–34. PMID   8603412.
4. Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer. 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID   10612805. S2CID   25576076.
5. "Entrez Gene: DEC1 deleted in esophageal cancer 1".

Further reading

• Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence". J. Biol. Chem. 283 (5): 2896–905. doi: 10.1074/jbc.M708624200 . PMC   4118587 . PMID   18025081.
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". Int. J. Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID   17943723. S2CID   28437103.
• Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006). "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter". Oncogene. 25 (23): 3296–306. doi:10.1038/sj.onc.1209363. PMC   4114758 . PMID   16462771.
• Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA (2006). "DEC1 expression in 1p-aberrant oligodendroglial neoplasms". Histol. Histopathol. 20 (4): 1173–7. PMID   16136500.
• Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML (2005). "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma". Oncogene. 24 (4): 697–705. doi: 10.1038/sj.onc.1208179 . PMID   15580306.
• Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML (Mar 1, 2011). "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis". British Journal of Cancer. 104 (5): 841–9. doi:10.1038/bjc.2011.25. PMC   3048215 . PMID   21326238.
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (Feb 1, 2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma". International Journal of Cancer. 122 (3): 587–94. doi:10.1002/ijc.23144. PMID   17943723. S2CID   28437103.