DEFA3

DEFA3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1DFN, 1ZMH, 1ZMI, 1ZMK, 2PM4, 2PM5
Identifiers
Aliases	DEFA3 , DEF3, HNP-3, HNP3, HP-3, HP3, defensin alpha 3
External IDs	OMIM: 604522 HomoloGene: 128756 GeneCards: DEFA3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,018,297 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; lung; ; blood; ; adipose tissue; ; spleen; ; right lung; ; colon; ; left ventricle; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity ; molecular function ;
Cellular component	extracellular region ; extracellular exosome ; azurophil granule lumen ; Golgi lumen ; extracellular space ;
Biological process	defense response to fungus ; intracellular estrogen receptor signaling pathway ; defense response to bacterium ; innate immune response in mucosa ; defense response ; defense response to virus ; antimicrobial humoral response ; antimicrobial humoral immune response mediated by antimicrobial peptide ; killing of cells of other organism ; antibacterial humoral response ; GO:0051636 defense response to Gram-negative bacterium ; GO:0051637 defense response to Gram-positive bacterium ; membrane disruption in other organism ; cellular response to lipopolysaccharide ;
	Sources:Amigo / QuickGO
Orthologs
	1668
	n/a
	ENSG00000239839 ; ENSG00000284835
	n/a
	P59666
	n/a
	NM_005217
	n/a
	NP_005208
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Defensin 3, dimer, Human. 1dfn.jpg — Defensin 3, dimer, Human.

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene.^[3] Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.

Function

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This peptide differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.^[3]

Related Research Articles

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Alpha defensins are a family of mammalian defensin peptides of the alpha subfamily. In mammals they are also known as cryptdins and are produced within the small bowel. Cryptdin is a portmanteau of crypt and defensin.

Beta defensins are a family of vertebrate defensins. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonization.

Defensin, alpha 1 also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1 gene. Human alpha defensin 1 belongs to the alpha defensin family of antimicrobial peptides.

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.

Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is encoded by the AZU1 gene.

Beta-defensin 103 is a protein that in humans is encoded by the DEFB103A gene.

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins founded by ovalbumin.

Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a protein that in humans is encoded by the DEFA5 gene. DEFA5 is expressed in the Paneth cells of the ileum.

Sperm-associated antigen 11B is a protein that in humans is encoded by the SPAG11B gene.

Beta-defensin 104 is a protein that in humans is encoded by the DEFB104A gene.

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene. DEFA6 is expressed in the Paneth cells of the ileum.

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene. HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria and viruses.