DEFB106A

DEFB106A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2LWL
Identifiers
Aliases	DEFB106A , BD-6, DEFB-6, DEFB106, defensin beta 106A
External IDs	HomoloGene: 134659 GeneCards: DEFB106A
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,829,053 bp
RNA expression pattern
	Top expressed in
	liver; ; cell; ; monocyte; ; blood; ; human musculoskeletal system; ; right lobe of liver; ; muscle of leg; ; fundus; ; gastrocnemius muscle; ; body of pancreas;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	lipopolysaccharide binding ; heparin binding ; protein binding ; CCR2 chemokine receptor binding ;
Cellular component	extracellular region ; nucleus ; cell surface ; extrinsic component of membrane ; microvesicle ; membrane ;
Biological process	defense response ; defense response to bacterium ; innate immune response ;
	Sources:Amigo / QuickGO
Orthologs
	245909
	n/a
	ENSG00000186579 ; ENSG00000285617
	n/a
	Q8N104
	n/a
	NM_152251
	n/a
	NP_689464
	n/a
	Wikidata
View/Edit Human

Last updated March 18, 2024

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.^[3]^[4]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.^[4]

Function

The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.^[5]

Related Research Articles

<span class="mw-page-title-main">Beta defensin</span>

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Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene.

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BG gene.

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

Beta-defensin 103 is a protein that in humans is encoded by the DEFB103A gene.

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.

Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene.

Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a protein that in humans is encoded by the DEFA5 gene. DEFA5 is expressed in the Paneth cells of the ileum.

Beta-defensin 104 is a protein that in humans is encoded by the DEFB104A gene.

Zinc finger protein 33B is a protein that in humans is encoded by the ZNF33B gene.

Protein DGCR6 is a protein that in humans is encoded by the DGCR6 gene.

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.

Beta-defensin 119 is a protein that in humans is encoded by the DEFB119 gene.

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.

Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene. DEFA6 is expressed in the Paneth cells of the ileum.

<span class="mw-page-title-main">DEFA3</span> Protein-coding gene in the species Homo sapiens

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene. Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.

<span class="mw-page-title-main">8p23.1 duplication syndrome</span> Medical condition

8p23.1 duplication syndrome is a rare genetic disorder caused by a duplication of a region from human chromosome 8. This duplication syndrome has an estimated prevalence of 1 in 64,000 births and is the reciprocal of the 8p23.1 deletion syndrome. The 8p23.1 duplication is associated with a variable phenotype including one or more of speech delay, developmental delay, mild dysmorphism, with prominent forehead and arched eyebrows, and congenital heart disease (CHD).

References

1 2 3 ENSG00000285617 GRCh38: Ensembl release 89: ENSG00000186579, ENSG00000285617 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi: 10.1073/pnas.042692699 . PMC 122330 . PMID 11854508.
1 2 "Entrez Gene: DEFB106A defensin, beta 106A".
↑ Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi: 10.3892/mmr.2013.1768 . PMID 24189797.

Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi: 10.4049/jimmunol.169.5.2516 . PMID 12193721.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX 10.1.1.108.7808 . doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
Semple CA, Rolfe M, Dorin JR (2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi: 10.1186/gb-2003-4-5-r31 . PMC 156587 . PMID 12734011.
Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683 . PMID 12916016.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence". BMC Genomics. 5 (1): 92. doi: 10.1186/1471-2164-5-92 . PMC 544879 . PMID 15588320.
Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865. S2CID 22355626.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000285617 GRCh38: Ensembl release 89: ENSG00000186579, ENSG00000285617 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11854508-3] Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi: 10.1073/pnas.042692699 . PMC 122330 . PMID 11854508.

[entrez-4] 1 2 "Entrez Gene: DEFB106A defensin, beta 106A".

[pmid_=_24189797-5] Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi: 10.3892/mmr.2013.1768 . PMID 24189797.

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DEFB106A

Contents

Function

Related Research Articles

References

Further reading