DEFB127

DEFB127
Identifiers
Aliases	DEFB127 , C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27, defensin beta 127
External IDs	HomoloGene: 89142 GeneCards: DEFB127
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 157,454 bp [1] End 159,163 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis kidney kidney skin of abdomen gonad testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region cell surface cellular component Biological process defense response defense response to bacterium innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140850 n/a Ensembl ENSG00000088782 n/a UniProt Q9H1M4 n/a RefSeq (mRNA) NM_139074 n/a RefSeq (protein) NP_620713 n/a Location (UCSC) Chr 20: 0.16 – 0.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene. ^{[3] [4]}

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000088782 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi: 10.1073/pnas.042692699 . PMC   122330 . PMID   11854508.
4. "Entrez Gene: DEFB127 defensin, beta 127".

Further reading

• van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131–8. doi: 10.1016/S0091-6749(99)70004-7 . PMID   10588992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID   12620395.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.