DGKD

DGKD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R79, 3BQ7
Identifiers
Aliases	DGKD , DGKdelta, dgkd-2, diacylglycerol kinase delta, DGK-delta
External IDs	OMIM: 601826 MGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 233,354,494 bp [1] End 233,472,104 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 87,781,009 bp [2] End 87,872,902 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach cerebellar hemisphere gastrocnemius muscle bone marrow skeletal muscle tissue blood fundus bone marrow cells gastric mucosa spleen Top expressed in spermatocyte thymus spermatid brown adipose tissue subcutaneous adipose tissue cerebellum interventricular septum spleen white adipose tissue blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding diacylglycerol kinase activity metal ion binding kinase activity protein binding diacylglycerol binding ATP binding NAD+ kinase activity identical protein binding protein homodimerization activity protein heterodimerization activity Cellular component cytoplasm membrane plasma membrane nucleus cytosol cytoplasmic vesicle Biological process intracellular signal transduction endocytosis epidermal growth factor receptor signaling pathway phosphorylation response to organic substance platelet activation multicellular organism development cell growth protein kinase C-activating G protein-coupled receptor signaling pathway diacylglycerol metabolic process protein transport second-messenger-mediated signaling protein homooligomerization lipid phosphorylation metabolism signal transduction glycerolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8527 227333 Ensembl ENSG00000077044 ENSG00000280873 ENSMUSG00000070738 UniProt Q16760 E9PUQ8 RefSeq (mRNA) NM_003648 NM_152879 NM_001377259 NM_177646 RefSeq (protein) NP_003639 NP_690618 NP_001364188 NP_808314 Location (UCSC) Chr 2: 233.35 – 233.47 Mb Chr 1: 87.78 – 87.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene. ^{[5] [6] [7]}

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. ^[7]

References

1. ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070738 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi: 10.1074/jbc.271.14.8394 . PMID   8626538.
6. Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi: 10.1074/jbc.M301542200 . PMID   12810723.
7. "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Further reading

• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi: 10.1093/dnares/2.4.167 . PMID   8590280.
• Bregoli L, Baldassare JJ, Raben DM (2001). "Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin". J. Biol. Chem. 276 (26): 23288–95. doi: 10.1074/jbc.M101501200 . PMID   11309392.
• Nagaya H, Wada I, Jia YJ, Kanoh H (2002). "Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains". Mol. Biol. Cell. 13 (1): 302–16. doi:10.1091/mbc.01-05-0255. PMC   65090 . PMID   11809841.
• Imai S, Sakane F, Kanoh H (2002). "Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation". J. Biol. Chem. 277 (38): 35323–32. doi: 10.1074/jbc.M202035200 . PMID   12084710.
• Sakane F, Imai S, Yamada K, et al. (2003). "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions". J. Biol. Chem. 277 (45): 43519–26. doi: 10.1074/jbc.M206895200 . PMID   12200442.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Imai S, Kai M, Yamada K, et al. (2005). "The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain". Biochem. J. 382 (Pt 3): 957–66. doi:10.1042/BJ20040681. PMC   1133971 . PMID   15228384.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Leach NT, Sun Y, Michaud S, et al. (2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice". Am. J. Hum. Genet. 80 (4): 792–9. doi:10.1086/513019. PMC   1852716 . PMID   17357084.