DGKZ

Last updated
DGKZ
Identifiers
Aliases DGKZ , DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDs OMIM: 601441; MGI: 1278339; HomoloGene: 37831; GeneCards: DGKZ; OMA:DGKZ - orthologs
EC number 2.7.1.107
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166597
NM_138306

RefSeq (protein)

NP_001160069
NP_612179

Location (UCSC) Chr 11: 46.33 – 46.38 Mb Chr 2: 91.76 – 91.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene. [5] [6]

Contents

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [6]

Interactions

DGKZ has been shown to interact with P110α. [7]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149091 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040479 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi: 10.1074/jbc.271.17.10230 . PMID   8626588.
  6. 1 2 "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa".
  7. Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. 278 (41): 39542–7. doi: 10.1074/jbc.M307153200 . ISSN   0021-9258. PMID   12890670.

Further reading