DHRS2

DHRS2
Identifiers
Aliases	DHRS2 , HEP27, SDR25C1, dehydrogenase/reductase (SDR family) member 2, dehydrogenase/reductase 2
External IDs	OMIM: 615194; HomoloGene: 68486; GeneCards: DHRS2; OMA:DHRS2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 23,630,115 bp [1] End 23,645,639 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of urinary bladder islet of Langerhans parotid gland right lobe of liver spleen gonad left ovary nipple amniotic fluid placenta n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding carbonyl reductase (NADPH) activity Cellular component cytoplasm mitochondrial matrix nuclear envelope mitochondrion nucleus Biological process cellular response to oxidative stress myeloid dendritic cell differentiation negative regulation of apoptotic process response to toxic substance C21-steroid hormone metabolic process negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10202 n/a Ensembl ENSG00000100867 n/a UniProt Q13268 n/a RefSeq (mRNA) NM_005794 NM_182908 NM_001318835 n/a RefSeq (protein) NP_001305764 NP_005785 NP_878912 n/a Location (UCSC) Chr 14: 23.63 – 23.65 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Dehydrogenase/reductase SDR family member 2 is an enzyme that in humans is encoded by the DHRS2 gene. ^{[3] [4] [5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000100867 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M (Nov 1995). "A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family". Eur J Biochem. 232 (2): 473–7. doi: 10.1111/j.1432-1033.1995.473zz.x . PMID   7556196.
4. Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M (Apr 2002). "Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells". Genomics. 79 (4): 608–15. doi:10.1006/geno.2002.6743. PMID   11944995.
5. Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U (Jun 2006). "Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue". Cell Mol Life Sci. 63 (10): 1205–13. doi:10.1007/s00018-006-6013-y. PMC   11136258 . PMID   16685466. S2CID   24562253.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: DHRS2 dehydrogenase/reductase (SDR family) member 2".

Further reading

• Donadel G, Garzelli C, Frank R, Gabrielli F (1991). "Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells". Eur. J. Biochem. 195 (3): 723–9. doi:10.1111/j.1432-1033.1991.tb15759.x. PMID   1847869.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Pellegrini S, Censini S, Guidotti S, et al. (2002). "A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product". Biochim. Biophys. Acta. 1574 (3): 215–22. doi:10.1016/s0167-4781(01)00323-2. PMID   11997086.
• Bauer K, Zemlin M, Hummel M, et al. (2002). "Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens". J. Immunol. 169 (3): 1349–56. doi: 10.4049/jimmunol.169.3.1349 . PMID   12133958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• DHRS2 human gene location in the UCSC Genome Browser .
• DHRS2 human gene details in the UCSC Genome Browser .