DHRS3

DHRS3
Identifiers
Aliases	DHRS3 , DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1, dehydrogenase/reductase (SDR family) member 3, dehydrogenase/reductase 3
External IDs	OMIM: 612830; MGI: 1315215; HomoloGene: 20994; GeneCards: DHRS3; OMA:DHRS3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.21 Start 12,567,910 bp [1] End 12,618,210 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 E1 Start 144,619,397 bp [2] End 144,654,779 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb right lobe of liver tibial nerve right lobe of thyroid gland nasal epithelium left lobe of thyroid gland prostate olfactory zone of nasal mucosa seminal vesicula subcutaneous adipose tissue Top expressed in vestibular membrane of cochlear duct transitional epithelium of urinary bladder left lobe of liver right kidney neural layer of retina external carotid artery proximal tubule lobe of prostate epithelium of stomach right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity nucleotide binding oxidoreductase activity NAD-retinol dehydrogenase activity NADP-retinol dehydrogenase activity Cellular component photoreceptor outer segment membrane integral component of membrane endoplasmic reticulum membrane membrane lipid droplet Biological process negative regulation of retinoic acid receptor signaling pathway retinol metabolic process roof of mouth development bone morphogenesis outflow tract morphogenesis regulation of ossification visual perception retinoid metabolic process cardiac septum morphogenesis electron transport chain regulation of retinoic acid receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9249 20148 Ensembl ENSG00000162496 ENSMUSG00000066026 UniProt O75911 Q5SUY4 O88876 RefSeq (mRNA) NM_004753 NM_001319225 NM_001324370 NM_001172424 NM_011303 NM_001357274 NM_001357275 NM_001357276 NM_001357277 RefSeq (protein) NP_001306154 NP_001311299 NP_004744 NP_001165895 NP_035433 NP_001344203 NP_001344204 NP_001344205 NP_001344206 Location (UCSC) Chr 1: 12.57 – 12.62 Mb Chr 4: 144.62 – 144.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Short-chain dehydrogenase/reductase 3 is an enzyme that in humans is encoded by the DHRS3 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000162496 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066026 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (Sep 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". J Biol Chem. 273 (34): 21790–9. doi: 10.1074/jbc.273.34.21790 . PMID   9705317.
6. Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi: 10.1074/jbc.M208882200 . PMC   1435693 . PMID   12226107.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
8. "Entrez Gene: DHRS3 dehydrogenase/reductase (SDR family) member 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Cerignoli F, Guo X, Cardinali B, et al. (2002). "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines". Cancer Res. 62 (4): 1196–204. PMID   11861404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes". BMC Genomics. 8: 42. doi: 10.1186/1471-2164-8-42 . PMC   1802077 . PMID   17286855.