DHX15

DHX15
Identifiers
Aliases	DHX15 , DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15, hPrp43
External IDs	OMIM: 603403 MGI: 1099786 HomoloGene: 1040 GeneCards: DHX15
Gene location (Human)
Chr.	Chromosome 4 (human)
End	24,584,554 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	52,347,856 bp
RNA expression pattern
	Top expressed in
	tibia; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; embryo; ; ganglionic eminence; ; cavity of mouth; ; caput epididymis; ; rectum; ; mucosa of urinary bladder;
	Top expressed in
	primitive streak; ; maxillary prominence; ; abdominal wall; ; hair follicle; ; medial ganglionic eminence; ; cumulus cells; ; somite; ; hand; ; ciliary body; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity ; nucleotide binding ; double-stranded RNA binding ; protein binding ; ATP binding ; helicase activity ; hydrolase activity ; nucleic acid binding ; RNA binding ; 3'-5' RNA helicase activity ;
Cellular component	U12-type spliceosomal complex ; nucleolus ; U2-type post-mRNA release spliceosomal complex ; cytoplasm ; nucleus ; nucleoplasm ; nuclear speck ;
Biological process	mRNA processing ; response to alkaloid ; response to toxic substance ; RNA splicing ; mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	1665
	13204
	ENSG00000109606
	ENSMUSG00000029169
	O43143
	O35286
	NM_001358
	NM_001042620 ; NM_007839
	NP_001349
	NP_001036085 ; NP_031865
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 12, 2022

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^[5]^[6]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[6] It may have tumor suppressor activity.^[7]

Related Research Articles

DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids. They are highly conserved in nine motifs and can be found in most prokaryotes and eukaryotes, but not all. Many organisms, including humans, contain DEAD-box (SF2) helicases, which are involved in RNA metabolism.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.

Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene.

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene.

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.

Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene.

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.

ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

Probable ATP-dependent RNA helicase DHX36 also known as DEAH box protein 36 (DHX36) or MLE-like protein 1 (MLEL1) or G4 resolvase 1 (G4R1) or RNA helicase associated with AU-rich elements (RHAU) is an enzyme that in humans is encoded by the DHX36 gene.

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31, also known as DDX31, is a human gene.

ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene.

Putative ATP-dependent RNA helicase DHX57 is an enzyme that in humans is encoded by the DHX57 gene.

RHAU is a 114-kDa human RNA helicase of the DEAH-box family of helicases encoded by the DHX36 gene.

DEAH-box helicase 8, is a protein that in humans is encoded by the DHX8 gene. This protein is member of the DEAH box polypeptide family. The main characteristic of this group is their conserved motif DEAH. A wide range of RNA helicases belongs to this family. Specifically, DHX8 acts as an ATP-dependent RNA helicase involved in splicing and the regulation of the releasing of spliced mRNAs from spliceosomes out of the nucleus. Published studies have shown the consequences of DHX8 mutations, some of them are critical for biological processes such as hematopoiesis and are related to some diseases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
1 2 "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".
↑ Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi: 10.1038/bjc.2017.273 . PMC 5672939 . PMID 28829764.

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585 . PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349 . PMID 12458796.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. doi:10.1128/MCB.14.11.7611. PMC 359297 . PMID 7935475.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388478-5] Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.

[entrez-6] 1 2 "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

[sitobmj2017-7] Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi: 10.1038/bjc.2017.273 . PMC 5672939 . PMID 28829764.

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DHX15

Related Research Articles

References

Further reading