DNASE1L2

DNASE1L2
Identifiers
Aliases	DNASE1L2 , DNAS1L2, deoxyribonuclease I-like 2, deoxyribonuclease 1 like 2
External IDs	OMIM: 602622; MGI: 1913955; HomoloGene: 74391; GeneCards: DNASE1L2; OMA:DNASE1L2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 2,235,816 bp [1] End 2,238,711 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 24,659,055 bp [2] End 24,662,079 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg skin of arm right hemisphere of cerebellum right lobe of thyroid gland left lobe of thyroid gland right frontal lobe skin of thigh vulva Brodmann area 9 Top expressed in lip esophagus transitional epithelium of urinary bladder skin of back skin of external ear umbilical cord neural layer of retina hair follicle granulocyte skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding calcium ion binding endonuclease activity nuclease activity hydrolase activity deoxyribonuclease activity metal ion binding deoxyribonuclease I activity Cellular component cytoplasm extracellular region nucleus Biological process hair follicle development DNA metabolic process DNA catabolic process corneocyte development nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1775 66705 Ensembl ENSG00000167968 ENSMUSG00000024136 UniProt Q92874 Q9D1G0 RefSeq (mRNA) NM_001301680 NM_001374 NM_025718 RefSeq (protein) NP_001288609 NP_001365 NP_079994 Location (UCSC) Chr 16: 2.24 – 2.24 Mb Chr 17: 24.66 – 24.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000167968 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024136 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID   9205125.
6. Germino GG, Weinstat-Saslow D, Himmelbauer H, Gillespie GA, Somlo S, Wirth B, Barton N, Harris KL, Frischauf AM, Reeders ST (Jun 1992). "The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region". Genomics. 13 (1): 144–51. doi:10.1016/0888-7543(92)90214-D. PMID   1577479.
7. "Entrez Gene: DNASE1L2 deoxyribonuclease I-like 2".

Further reading

• Jäger K, Fischer H, Tschachler E, Eckhart L (2008). "Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression". Differentiation. 75 (10): 939–46. doi:10.1111/j.1432-0436.2007.00183.x. PMID   17490414.
• Fischer H, Eckhart L, Mildner M, et al. (2007). "DNase1L2 degrades nuclear DNA during corneocyte formation". J. Invest. Dermatol. 127 (1): 24–30. doi: 10.1038/sj.jid.5700503 . PMID   16902420.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Shiokawa D, Matsushita T, Kobayashi T, et al. (2005). "Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines". Genomics. 84 (1): 95–105. doi:10.1016/j.ygeno.2004.02.003. PMID   15203207.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID   11141064.