DPP7

Last updated

DPP7
Protein DPP7 PDB 3JYH.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DPP7 , DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDs OMIM: 610537; MGI: 1933213; HomoloGene: 22748; GeneCards: DPP7; OMA:DPP7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013379

NM_031843

RefSeq (protein)

NP_037511

NP_114031

Location (UCSC) Chr 9: 137.11 – 137.12 Mb Chr 2: 25.24 – 25.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene. [5] [6] [7]

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000176978 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026958 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. doi: 10.4049/jimmunol.163.6.3092 . PMID   10477574.
  6. Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC   1221570 . PMID   11139392.
  7. 1 2 "Entrez Gene: DPP7 dipeptidyl-peptidase 7".

Further reading