DPPA3

DPPA3
Identifiers
Aliases	DPPA3 , STELLA, developmental pluripotency associated 3, Pgc7
External IDs	OMIM: 608408; HomoloGene: 138483; GeneCards: DPPA3; OMA:DPPA3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,717,559 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; duodenum; ; ventricular zone; ; right testis; ; blood; ; muscle tissue; ; left testis; ; liver; ; right ovary;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	methylated histone binding ;
Cellular component	male pronucleus ; cytoplasm ; nucleus ; female pronucleus ;
Biological process	multicellular organism development ; protection of DNA demethylation of female pronucleus ; negative regulation of DNA demethylation ; regulation of genetic imprinting ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	359787
	n/a
	ENSG00000187569
	n/a
	Q6W0C5
	n/a
	NM_199286
	n/a
	NP_954980
	n/a
	Wikidata
View/Edit Human

Last updated November 16, 2024

Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.^[3]

This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.^[3]

Related Research Articles

Oct-4, also known as POU5F1, is a protein that in humans is encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.

<span class="mw-page-title-main">Homeobox protein NANOG</span> Mammalian protein found in humans

Homeobox protein NANOG(hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. hNanog is encoded in humans by the NANOG gene. Several types of cancer are associated with NANOG.

In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. Such control is also often associated with alternative covalent modifications of histones.

Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 and GDF1.

SRY -box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.

Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene.

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene.

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.

Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.

Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.

Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state. As the cells begin to differentiate, Rex1 is severely and abruptly downregulated.

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187569 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: DPPA3 developmental pluripotency associated 3".

Nakamura T, Arai Y, Umehara H, et al. (2007). "PGC7/Stella protects against DNA demethylation in early embryogenesis". Nat. Cell Biol. 9 (1): 64–71. doi:10.1038/ncb1519. PMID 17143267. S2CID 1947132.
Elliman SJ, Wu I, Kemp DM (2006). "Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin". J. Biol. Chem. 281 (1): 16–9. doi: 10.1074/jbc.C500415200 . PMID 16291741.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bortvin A, Goodheart M, Liao M, Page DC (2004). "Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice". BMC Dev. Biol. 4: 2. doi: 10.1186/1471-213X-4-2 . PMC 362866 . PMID 15018652.
Clark AT, Rodriguez RT, Bodnar MS, et al. (2004). "Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma". Stem Cells. 22 (2): 169–79. doi: 10.1634/stemcells.22-2-169 . PMID 14990856. S2CID 38136098.
Bowles J, Teasdale RP, James K, Koopman P (2004). "Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours". Cytogenet. Genome Res. 101 (3–4): 261–5. doi:10.1159/000074346. PMID 14684992. S2CID 7005986.
Payer B, Saitou M, Barton SC, et al. (2004). "Stella is a maternal effect gene required for normal early development in mice". Curr. Biol. 13 (23): 2110–7. doi: 10.1016/j.cub.2003.11.026 . PMID 14654002. S2CID 2010581.
Sato M, Kimura T, Kurokawa K, et al. (2002). "Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells". Mech. Dev. 113 (1): 91–4. doi:10.1016/S0925-4773(02)00002-3. PMID 11900980. S2CID 12877378.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187569 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: DPPA3 developmental pluripotency associated 3".

[1]

[2]

[3]

DPPA3

Related Research Articles

References

Further reading