DPYSL2

DPYSL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GSE, 2VM8
Identifiers
Aliases	DPYSL2 , CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
External IDs	OMIM: 602463; MGI: 1349763; HomoloGene: 74392; GeneCards: DPYSL2; OMA:DPYSL2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.2 Start 26,514,031 bp [1] End 26,658,178 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D1|14 34.6 cM Start 67,040,313 bp [2] End 67,106,137 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve pars reticulata subthalamic nucleus pars compacta superior vestibular nucleus external globus pallidus pons cerebellar vermis lateral nuclear group of thalamus paraflocculus of cerebellum Top expressed in paraventricular nucleus of hypothalamus globus pallidus anterior amygdaloid area habenula medial geniculate nucleus dorsomedial hypothalamic nucleus ventral tegmental area medial dorsal nucleus anterior horn of spinal cord subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding dihydropyrimidinase activity protein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity identical protein binding Cellular component cytoplasm cytosol membrane extracellular exosome microtubule cytoskeleton plasma membrane Biological process regulation of neuron differentiation cell differentiation endocytosis regulation of axon extension nervous system development multicellular organism development brain development cytoskeleton organization nucleobase-containing compound metabolic process signal transduction axon guidance pyrimidine nucleobase catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1808 12934 Ensembl ENSG00000092964 ENSMUSG00000022048 UniProt Q16555 O08553 RefSeq (mRNA) NM_001386 NM_001197293 NM_001244604 NM_009955 NM_001378767 RefSeq (protein) NP_001184222 NP_001231533 NP_001377 NP_034085 NP_001365696 Location (UCSC) Chr 8: 26.51 – 26.66 Mb Chr 14: 67.04 – 67.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene. ^{[5] [6]}

Interactions

DPYSL2 has been shown to interact with CRMP1, ^[7] Adaptor-related protein complex 2, alpha 1 ^[8] and NUMB. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000092964 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022048 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID   8973361.
6. "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
7. Leung T, Ng Yvonne, Cheong Albert, Ng Chong Han, Tan Ivan, Hall Christine, Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3). Netherlands: 445–9. doi: 10.1016/S0014-5793(02)03736-5 . ISSN   0014-5793. PMID   12482610. S2CID   45499981.
8. Nishimura T, Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9). England: 819–26. doi:10.1038/ncb1039. ISSN   1465-7392. PMID   12942088. S2CID   12118386.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995). "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33". Nature. 376 (6540): 509–14. Bibcode:1995Natur.376..509G. doi:10.1038/376509a0. PMID   7637782. S2CID   4309140.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Roberts RG, Freeman TC, Kendall E, et al. (1996). "Characterization of DRP2, a novel human dystrophin homologue". Nat. Genet. 13 (2): 223–6. doi:10.1038/ng0696-223. PMID   8640231. S2CID   20939305.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Kitamura K, Takayama M, Hamajima N, et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene". DNA Res. 6 (5): 291–7. doi: 10.1093/dnares/6.5.291 . PMID   10574455.
• Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522". Biochemistry. 39 (15): 4267–75. doi:10.1021/bi992323h. PMID   10757975.
• Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules". J. Biol. Chem. 275 (24): 17917–20. doi: 10.1074/jbc.C000179200 . PMID   10770920.
• Arimura N, Inagaki N, Chihara K, et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse". J. Biol. Chem. 275 (31): 23973–80. doi: 10.1074/jbc.M001032200 . PMID   10818093.
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi: 10.1074/jbc.M003277200 . PMID   10956643.
• Santolini E, Puri C, Salcini AE, et al. (2001). "Numb Is an Endocytic Protein". J. Cell Biol. 151 (6): 1345–52. doi:10.1083/jcb.151.6.1345. PMC   2190585 . PMID   11121447.
• Lee S, Kim JH, Lee CS, et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi: 10.1074/jbc.M108047200 . PMID   11741937.
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain". Protein Expression in Down Syndrome Brain. pp. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN   978-3-211-83704-7. PMID   11771764.{{cite book}}: |journal= ignored (help)
• Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID   12134159. S2CID   22934366.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi: 10.1016/S0014-5793(02)03736-5 . PMID   12482610. S2CID   45499981.
• Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID   12942088. S2CID   12118386.
• Nakata K, Ujike H, Tanaka Y, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans". Neurosci. Lett. 349 (3): 171–4. doi:10.1016/S0304-3940(03)00824-3. PMID   12951196. S2CID   30637558.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.