Daniel Herschlag

Last updated
Daniel Herschlag
Born (1958-10-16) October 16, 1958 (age 65)
Nationality American
Alma mater Binghamton University, Brandeis University, University of Colorado at Boulder
Known for Enzymology RNA biochemistry
Awards William C. Rose Award (2010)
Scientific career
Fields Biochemistry
Institutions Stanford University
Doctoral advisor William Jencks
Other academic advisors Tom Cech
Doctoral students Rhiju Das Geeta Narlikar

Daniel Herschlag (born October 16, 1958) is an American biochemist and Professor of Biochemistry at the Stanford University School of Medicine. His research uses an interdisciplinary approach to advance our understanding of the fundamental behavior of RNA and proteins. He is well known for his application of rigorous kinetic and mechanistic approaches to RNA and protein systems. [1]

Contents

Education

Herschlag received a B.S. degree in biochemistry from Binghamton University in 1982. He began his graduate studies at University of Minnesota then moved on to complete his Ph.D. degree in Biochemistry at Brandeis University under W.P. Jencks in 1988. [2]

Career

Herschlag was a Helen Hay Whitney Postdoctoral Fellow at the University of Colorado at Boulder from 1989 to 1992. [3] He conducted post-doctoral research on the mechanism of the newly discovered RNA self-splicing reaction in the lab of Tom Cech.

In 1992, Herschlag joined the faculty of the Department of Biochemistry in the Stanford University School of Medicine, earning tenure in 1997. He was promoted to full professor in 2002.

In 2011, he was appointed the Senior Associate Dean of Graduate Education and Postdoctoral Affairs for the Stanford University School of Medicine. [4] [5]

Selected awards

Selected publications

Personal

Herschlag currently lives in Menlo Park, CA with his wife and two children.

See also

Related Research Articles

<span class="mw-page-title-main">Biophysics</span> Study of biological systems using methods from the physical sciences

Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology.

<span class="mw-page-title-main">Vijay S. Pande</span> American scientist

Vijay Satyanand Pande is a Trinidadian–American scientist and venture capitalist. Pande is best known for orchestrating the distributed computing protein-folding research project known as Folding@home. His research is focused on distributed computing and computer-modelling of microbiology, and on improving computer simulations regarding drug-binding, protein design, and synthetic biomimetic polymers. He is currently a general partner at venture capital firm Andreessen Horowitz.

<span class="mw-page-title-main">Silent mutation</span> DNA mutation with no observable effect on an organisms phenotype

Silent mutations are mutations in DNA that do not have an observable effect on the organism's phenotype. They are a specific type of neutral mutation. The phrase silent mutation is often used interchangeably with the phrase synonymous mutation; however, synonymous mutations are not always silent, nor vice versa. Synonymous mutations can affect transcription, splicing, mRNA transport, and translation, any of which could alter phenotype, rendering the synonymous mutation non-silent. The substrate specificity of the tRNA to the rare codon can affect the timing of translation, and in turn the co-translational folding of the protein. This is reflected in the codon usage bias that is observed in many species. Mutations that cause the altered codon to produce an amino acid with similar functionality are often classified as silent; if the properties of the amino acid are conserved, this mutation does not usually significantly affect protein function.

<span class="mw-page-title-main">Robert G. Roeder</span> American biochemist

Robert G. Roeder is an American biochemist. He is known as a pioneer scientist in eukaryotic transcription. He discovered three distinct nuclear RNA polymerases in 1969 and characterized many proteins involved in the regulation of transcription, including basic transcription factors and the first mammalian gene-specific activator over five decades of research. He is the recipient of the Gairdner Foundation International Award in 2000, the Albert Lasker Award for Basic Medical Research in 2003, and the Kyoto Prize in 2021. He currently serves as Arnold and Mabel Beckman Professor and Head of the Laboratory of Biochemical and Molecular Biology at The Rockefeller University.

Marlene Belfort is an American biochemist known for her research on the factors that interrupt genes and proteins. She is a fellow of the American Academy of Arts and Sciences and has been admitted to the United States National Academy of Sciences.

<span class="mw-page-title-main">Peter Walter</span> German-American molecular biologist and biochemist

Peter Walter is a German-American molecular biologist and biochemist. He is currently the Director of the Bay Area Institute of Science at Altos Labs and an emeritus professor at the Department of Biochemistry and Biophysics of the University of California, San Francisco (UCSF). He was a Howard Hughes Medical Institute (HHMI) Investigator until 2022.

<span class="mw-page-title-main">Roger D. Kornberg</span> American biochemist and professor of structural biology

Roger David Kornberg is an American biochemist and professor of structural biology at Stanford University School of Medicine. Kornberg was awarded the Nobel Prize in Chemistry in 2006 for his studies of the process by which genetic information from DNA is copied to RNA, "the molecular basis of eukaryotic transcription."

Franz-Ulrich Hartl is a German biochemist and the current Executive Director of the Max Planck Institute of Biochemistry. He is known for his pioneering work in chaperone-mediated protein folding.

<span class="mw-page-title-main">Stephen J. Benkovic</span> American chemist

Stephen James Benkovic is an American chemist known for his contributions to the field of enzymology. He holds the Evan Pugh University Professorship and Eberly Chair in Chemistry at The Pennsylvania State University. He has developed boron compounds that are active pharmacophores against a variety of diseases. Benkovic has concentrated on the assembly and kinetic attributes of the enzymatic machinery that performs DNA replication, DNA repair, and purine biosynthesis.

Olke C. Uhlenbeck is a Professor Emeritus of Biochemistry at the University of Colorado Boulder and at Northwestern University.

<span class="mw-page-title-main">Paul Schimmel</span> American chemist

Paul Reinhard Schimmel is an American biophysical chemist and translational medicine pioneer.

Scott A. Strobel is the provost of Yale University as well as a professor of molecular biophysics and biochemistry. He was the vice provost for Science Initiatives and vice president for West Campus Planning & Program Development. An educator and researcher, he has led a number of Yale initiatives over the past two decades. Strobel was appointed as Yale's provost in 2020.

<span class="mw-page-title-main">Ruth Nussinov</span> Bioinformatician

Ruth Nussinov is an Israeli-American biologist born in Rehovot who works as a Professor in the Department of Human Genetics, School of Medicine at Tel Aviv University and is the Senior Principal Scientist and Principal Investigator at the National Cancer Institute, National Institutes of Health. Nussinov is also the Editor in Chief of the Current Opinion in Structural Biology and formerly of the journal PLOS Computational Biology.

Ruma Banerjee is a professor of enzymology and biological chemistry at the University of Michigan Medical School. She is an experimentalist whose research has focused on unusual cofactors in enzymology.

Sarah L. Keller is an American biophysicist, studying problems at the intersection between biology and chemistry. She investigates self-assembling soft matter systems. Her current main research focus is understanding how simple lipid mixtures within bilayer membranes give rise to membrane's complex phase behavior.

Karen Renee Gibson Fleming is a Professor of Biophysics at Johns Hopkins University. She investigates the energetics of transmembrane helix-helix interactions. Fleming was awarded the 2020 Protein Society Carl Brändén Award.

Karin Musier-Forsyth, an American biochemist, is an Ohio Eminent Scholar on the faculty of the Department of Chemistry & Biochemistry at Ohio State University. Musier-Forsyth's research involves biochemical, biophysical and cell-based approaches to understand the interactions of proteins and RNAs involved in protein synthesis and viral replication, especially in HIV.

Judith Frydman is a biochemist and the Donald Kennedy Chair in the School of Humanities & Sciences and Professor of Genetics at Stanford University. Her research focuses on protein folding.

<span class="mw-page-title-main">S. Walter Englander</span> American biophysicist

Solomon Walter Englander is the Gershon-Cohen Professor Emeritus of Biochemistry, Biophysics, and Medical Science at the University of Pennsylvania. He is known for pioneering the development of the field of hydrogen exchange (HX) studies.

Shu-ou Shan is a Chinese American biologist who is a professor at the California Institute of Technology. Her research combines mechanistic enzymology with biophysical characterization techniques to understand biogenesis pathways. She was awarded the 2024 National Academy of Sciences Award in Molecular Biology.

References

  1. "Daniel Herschlag named this year's William C. Rose Award winner". ASBMB. Archived from the original on 9 November 2012. Retrieved 7 April 2013.
  2. "Meet Dr. Herschlag from Stanford University". UCSF. 6 September 2012. Retrieved 7 April 2013.
  3. "Helen Hay Whitney Foundation award list". Archived from the original on 2016-03-04.
  4. "Stanford Dean's Newsletter". Archived from the original on 2013-01-25. Retrieved 2012-10-14.
  5. "Stanford University School of Medicine Leadership List". Archived from the original on 2012-10-14. Retrieved 2012-10-14.
  6. "Pfizer Awardees List" (PDF). Archived from the original (PDF) on 2017-01-01. Retrieved 2012-10-14.
  7. "Cope Scholar Award Announcement".
  8. "ASBMB William Rose award announcement".
  9. "Dan Herschlag". www.nasonline.org. Retrieved 2020-01-31.
  10. University, Stanford (2018-05-02). "Three Stanford faculty elected to the National Academy of Sciences". Stanford News. Retrieved 2020-01-31.
  11. "Dan Herschlag to Receive Biophysical Society's 2020 Founders Award". The Biophysical Society. Retrieved 2020-01-31.
  12. "RNA chaperoning earns alumnus science accolades – Alumni Association | Binghamton University". Alumni Association - Binghamton University. Retrieved 2020-02-15.