David Crich | |
---|---|
Born | David Crich 21 July 1959 Chesterfield, Derbyshire, England |
Nationality | British, American |
Alma mater | University of Surrey Paris-Sud University |
Scientific career | |
Fields | Chemistry |
Institutions | |
Doctoral advisor | Derek Barton |
David Crich (born July 21, 1959) is a British American organic chemist and is a professor at the University of Georgia. [1]
He is widely known for his involvement in the development of mechanistic and synthetic organic chemistry, carbohydrate chemistry and medicinal chemistry. He has supervised over 75 doctoral students and has published over 450 peer-reviewed articles in scientific journals. [2] The Crich beta-mannosylation reaction is named after him. He has made seminal contributions to understanding chemical glycosylation mechanisms.
Born in the town of Chesterfield England, Crich received a Bachelor of Science degree from the University of Surrey in 1981 before joining the group of Sir Derek Barton, Nobel Laureate, at the Institut de Chimie des Substances Naturelles (ICSN) in France. [3] Under Barton, he learned free radical chemistry and was responsible for the development of the Barton decarboxylation reaction, [4] [5] [6] for which he was awarded the degree of Docteur es Sciences by the Universite de Paris XI Paris-Sud University (Orsay) in 1984. Crich stayed at the ICSN as a postdoctoral fellow with Derek Barton and Pierre Potier from 1984 to 1985.
Crich began his independent career in 1985 when he took up a lectureship in chemistry in the Christopher Ingold Laboratories at University College London (UCL) in London. After five years at UCL, Crich moved to the University of Illinois (UIC) in Chicago where he rose through the ranks to become Distinguished Professor of Organic Chemistry. It was at UIC where Crich discovered the Crich beta-mannosylation reaction. In 2007, Crich relocated to Wayne State University in Detroit as the Schaap Professor of Chemistry, before returning to the ICSN, where he was appointed the institute's director. Crich returned to Wayne State as the Schaap Professor in 2011 and stayed there until 2019 when he moved to the University of Georgia as the Georgia Research Alliance and David Chu Eminent Scholar in Drug Design. [7]
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The Crich β-mannosylation in organic chemistry is a synthetic strategy which is used in carbohydrate synthesis to generate a 1,2-cis-glycosidic bond. This type of linkate is generally very difficult to make, and specific methods like the Crich β-mannosylation are used to overcome these issues. The technique takes its name from its developer, Professor David Crich.
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