Established | 1966 |
---|---|
Chairman | David D. Ginty |
Location | Boston, MA |
Website | http://neuro.hms.harvard.edu |
The Department of Neurobiology at Harvard Medical School is located in the Longwood Medical Area of Boston, MA. [1] [2] The Department is part of the Basic Research Program at Harvard Medical School, with research pertaining to development of the nervous system, sensory neuroscience, neurophysiology, and behavior. The Department was founded by Stephen W. Kuffler in 1966, the first department dedicated to Neurobiology in the world. The mission of the Department is “to understand the workings of the brain through basic research and to use that knowledge to work toward preventive and therapeutic methods that alleviate neurological diseases”. [3]
Prior to moving to Boston, while at Johns Hopkins University, Kuffler recruited Torsten N. Wiesel, David Hubel, David Potter, and Edwin Furshpan to work on various aspects of nerve physiology. As Hubel later recounted, Wiesel, Hubel, and Kuffler "...represented central nervous system physiology; Furshpan and Potter (and of course Steve) represented synaptic physiology; and Ed Kravitz, representing neurochemistry, arrived soon after our move to Harvard." [4]
The group moved to Harvard Medical School in 1959 as a sub-department within the Department of Pharmacology, headed by Otto Krayer. In 1966, Kuffler came up with the term neurobiology to unite these sub-disciplines into the first-ever Department of Neurobiology, an independent department at Harvard Medical School. Hubel later said, “I can’t be absolutely certain how the term neurobiology originated, but I believe Steve Kuffler invented it when we had to think up a title for our department when it was founded on 1965. That he almost single-handedly invented the field of neurobiology, I think few would dispute.” [5]
Early on, the founders of the Department worked to recruit students and researchers to work in their laboratories, and paid special attention to recruiting with a social conscience. According to David Potter, "There’s another fact of the department that interests me personally, [that] has to do with our involvement in acceptance of medical students who were minorities… it was something new, and it was a political struggle and that made it very interesting. I spent a lot of time there, time that I should have been spending in the lab doing science and research, on admissions and recruiting, and I got kind of devoted to that. I don’t regret that at all, it was an education for me." [6]
Wiesel chaired the department from 1973, and was succeeded by David Potter in 1982, Gerald Fishbach in 1990, and Carla Shatz in 2000 (the first female to chair such a department). In 2008, Michael E. Greenberg assumed the position of Department chair, a position he held until 2022. Under his leadership, he has integrated Harvard Neurobiology with neuroscience in the Harvard-affiliated hospitals, such as Boston Children’s Hospital, Dana-Farber Cancer Center, Massachusetts General Hospital, and the Massachusetts Eye and Ear Infirmary. To further facilitate the interaction and collaboration of neuroscientists at Harvard University in Cambridge, MA and Harvard Medical School, the Harvard Brain Initiative, co-chaired by Michael Greenberg and Joshua Sanes, funds collaborations and research initiatives specifically between members of the Department faculty and other neuroscientists at Harvard University. [7]
David D. Ginty assumed the role of chair in 2022.
In October 2016, current and past faculty, students, and researchers will gather in Boston to celebrate the 50th Anniversary of the founding of the Department.
The Department currently has 38 faculty members and close to 300 graduate students, post-doctoral fellows, and other research staff.
The Department’s current research generally encompasses the following areas:
The Department's faculty also participates in the Program in Neuroscience [31] PhD Program offered by Harvard University.
Nobel Prize in Physiology or Medicine:
Albert Lasker Award for Basic Medical Research:
NIH Director's Pioneer Awards:
NIH Director's New Innovator Awards:
American Academy of Arts and Sciences
Neuroscience is the scientific study of the nervous system, its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences.
Margaret Stratford Livingstone is the Takeda Professor of Neurobiology in the Department of Neurobiology at Harvard Medical School in the field of visual perception. She authored the book Vision and Art: The Biology of Seeing. She was elected a member of the American Academy of Arts and Sciences in 2015 and was elected to the National Academy of Sciences in 2020.
Torsten Nils Wiesel is a Swedish neurophysiologist. With David H. Hubel, he received the 1981 Nobel Prize in Physiology or Medicine, for their discoveries concerning information processing in the visual system; the prize was shared with Roger W. Sperry for his independent research on the cerebral hemispheres.
David Hunter Hubel was an American Canadian neurophysiologist noted for his studies of the structure and function of the visual cortex. He was co-recipient with Torsten Wiesel of the 1981 Nobel Prize in Physiology or Medicine, for their discoveries concerning information processing in the visual system. For much of his career, Hubel worked as the Professor of Neurobiology at Johns Hopkins University and Harvard Medical School. In 1978, Hubel and Wiesel were awarded the Louisa Gross Horwitz Prize from Columbia University. In 1983, Hubel received the Golden Plate Award of the American Academy of Achievement.
A cortical column is a group of neurons forming a cylindrical structure through the cerebral cortex of the brain perpendicular to the cortical surface. The structure was first identified by Mountcastle in 1957. He later identified minicolumns as the basic units of the neocortex which were arranged into columns. Each contains the same types of neurons, connectivity, and firing properties. Columns are also called hypercolumn, macrocolumn, functional column or sometimes cortical module. Neurons within a minicolumn (microcolumn) encode similar features, whereas a hypercolumn "denotes a unit containing a full set of values for any given set of receptive field parameters". A cortical module is defined as either synonymous with a hypercolumn (Mountcastle) or as a tissue block of multiple overlapping hypercolumns.
The Ferrier Lecture is a Royal Society lectureship given every three years "on a subject related to the advancement of natural knowledge on the structure and function of the nervous system". It was created in 1928 to honour the memory of Sir David Ferrier, a neurologist who was the first British scientist to electronically stimulate the brain for the purpose of scientific study.
Complex cells can be found in the primary visual cortex (V1), the secondary visual cortex (V2), and Brodmann area 19 (V3).
Carla J. Shatz is an American neurobiologist and an elected member of the American Academy of Arts and Sciences, the American Philosophical Society, the National Academy of Sciences, and the National Academy of Medicine.
Winfried Denk is a German physicist. He built the first two-photon microscope while he was a graduate student in Watt W. Webb's lab at Cornell University, in 1989.
Catherine Dulac is a French–American biologist. She is the Higgins Professor in Molecular and Cellular Biology at Harvard University, where she served as department chair from 2007 to 2013. She is also an investigator at the Howard Hughes Medical Institute. She was born in 1963 in France. She came to the United States for her postdoctoral study in 1991.
Michael Greenberg is an American neuroscientist who specializes in molecular neurobiology. He served as the Chair of the Department of Neurobiology at Harvard Medical School from 2008 to 2022.
Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise.
Christine Elizabeth Holt FRS, FMedSci is a British developmental neuroscientist.
Rosalind Anne Segal is an American neurobiologist. She is a Professor of Neurobiology at Harvard Medical School and the Dana Farber Cancer Institute., and the Dean for Graduate Education at Harvard Medical School Segal's work employs modern methods of cell and molecular biology to study the development of the mammalian brain with the goal of understanding how disruption of this normal process leads to the formation of brain malignancies.
Hilmar Bading is a German physician and neuroscientist. He is a member of the German National Academy of Science Leopoldina.
A. James Hudspeth is the F.M. Kirby Professor at Rockefeller University in New York City, where he is director of the F.M. Kirby Center for Sensory Neuroscience. His laboratory studies the physiological basis of hearing.
Yang Dan is a Chinese-American neuroscientist. She is the Paul Licht Distinguished Professor of Neurobiology at the University of California, Berkeley and a Howard Hughes Medical Institute (HHMI) Investigator. She is a past recipient of the Alfred P. Sloan Research Fellowship, Beckman Young Investigator Award, and Society for Neuroscience Research Awards for Innovation in Neuroscience. Recognized for her research on the neural circuits that control behavior, she was elected to the US National Academy of Sciences in 2018.
Chenghua Gu is a Professor of Neurobiology at the Harvard Medical School where her research focuses on the Blood–brain barrier. She is also part of the Harvard Brain Science Initiative and has won numerous awards for her groundbreaking research on the brain's vascular component.
Michael Paul Stryker is an American neuroscientist specializing in studies of how spontaneous neural activity organizes connections in the developing mammalian brain, and for research on the organization, development, and plasticity of the visual system in the ferret and the mouse.
Ehud Zohary is an Israeli scientist, professor of neurobiology at the Edmond and Lilly Safra Center for Brain Science and Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem.