Dexamyl

Last updated

Dexamyl (or Drinamyl in the UK) was a brand name combination drug composed of sodium amobarbital (previously called amylbarbitone and its brand name Amytal) and dextroamphetamine sulfate (Dexedrine) within the same pill. It was widely abused, and is no longer manufactured. [1]

Contents

First introduced in 1950 by Smith, Kline & French (SKF), Dexamyl was marketed as an anorectic obesity medication as well as an anxiolytic and antidepressant medication that did not cause agitation. Racemic amphetamine sulfate had already been marketed over-the-counter (OTC) since 1933 as a nasal decongestant inhaler device under the brand name Benzedrine, and also as an oral tablet since 1938. Dexamyl utilized its enantiopure isomer of greater central nervous system (CNS) selectivity, dextroamphetamine sulfate, to elevate mood and suppress appetite, whereas the concomitant barbiturate was included to broadly counteract potential adverse effects from dextroamphetamine. Its name is a portmanteau of dextro- amphetamine and amyl- barbitone.

Dexamyl was discontinued in 1982 by SKF in favor of monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) which were recently developed and shared treatment indications with Dexamyl yet lacked the high dependence potential and abuse liability which characterized long-term Dexamyl usage.

History

British prime minister Anthony Eden was prescribed Dexamyl; he was using it to treat abdominal pain. It has been suggested that the drug impaired his judgment during the Suez Crisis. [2] The failure of his Suez policies led to his ousting while he was recovering in Jamaica.

In Britain during the early 1960s the drug was taken by "tired housewives", and was also abused by youths who took excessively large doses and nicknamed the triangular blue tablets "purple hearts" or "blues." [3] This became a celebrated part of the Mod subculture. Dexamyl is the recreational drug of choice for the main character of the film Quadrophenia , who eventually suffers from amphetamine psychosis. They were widely abused. [4]

In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees", a reference to its appearance. [5]

In his autobiography My Life of Absurdity, author Chester Himes writes of his use of Dexamyl in the mid-1950s. He also writes that he stopped taking the drug after his friend Vandi Haygood died from "steady doses of Dexamyl". [6]

Dr. George C. Nichopoulos was indicted in May 1980 for having improperly prescribed Dexamyl and phenmetrazine (Preludin) to the singer Jerry Lee Lewis, despite knowing he was addicted to them. [7]

Dr. Patrick A. Mazza, team physician for the Reading Phillies, said he prescribed Dexamyl, Eskatrol, Dexedrine, and Preludin for Steve Carlton, Larry Christenson, Tim McCarver, Pete Rose, Larry Bowa, and Greg Luzinski. The charges against Mazza were dropped after he contended that he had provided the prescriptions in good faith to the baseball players at their request. [8] The pill was writer Terry Southern's drug of choice for many years. [9]

See also

Related Research Articles

<span class="mw-page-title-main">Amphetamine</span> Central nervous system stimulant

Amphetamine is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to the significant health risks associated with recreational use.

<span class="mw-page-title-main">Hypnotic</span> Drug whose use induces sleep

Hypnotic, or soporific drugs, commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to induce sleep and to treat insomnia (sleeplessness).

<span class="mw-page-title-main">Psychiatric medication</span> Medication used to treat mental disorders

A psychiatric or psychotropic medication is a psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental illnesses. These medications are typically made of synthetic chemical compounds and are usually prescribed in psychiatric settings, potentially involuntarily during commitment. Since the mid-20th century, such medications have been leading treatments for a broad range of mental disorders and have decreased the need for long-term hospitalization, thereby lowering the cost of mental health care. The recidivism or rehospitalization of the mentally ill is at a high rate in many countries, and the reasons for the relapses are under research.

<span class="mw-page-title-main">Benzphetamine</span> Chemical compound

Benzphetamine is a substituted amphetamine used short-term along with a doctor-approved, reduced-calorie diet, exercise, and behavioral program for weight loss. It is prescribed for obesity to people who have been unable to lose weight through exercise and dieting alone. It is a prodrug to dextroamphetamine and dextromethamphetamine.

<span class="mw-page-title-main">Bupropion</span> Substituted cathinone medication mainly used for depression and smoking cessation

Bupropion, sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction; it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder.

<span class="mw-page-title-main">Dextroamphetamine</span> CNS stimulant and isomer of amphetamine

Dextroamphetamine, also known as D-amphetamine (d-amphetamine), is a catecholaminergic central nervous system stimulant and enantiomer of the drug amphetamine. It is used medicinally, primarily as a pharmaceutical treatment for attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also commonly used as a performance enhancer in athleticism, as well as a corticostriatal-based cognitive enhancer and task-salience promoter applied to various academic pursuits and other curricular contexts usually relating to aiding in scholastic achievement. It is also alternatively used as a eugeroic, and recreationally; both as an aphrodisiac and euphoriant due to its rewarding and dopaminergic effects which are typically more pronounced in non-ADHD (‘neurotypical’) individuals.

<span class="mw-page-title-main">Adderall</span> Drug mixture used mainly to treat ADHD and narcolepsy

Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. Both enantiomers are stimulants, but differ enough to give Adderall an effects profile distinct from those of racemic amphetamine or dextroamphetamine, which are marketed as Evekeo and Dexedrine/Zenzedi, respectively. Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used illicitly as an athletic performance enhancer, cognitive enhancer, appetite suppressant, and recreationally as a euphoriant. It is a central nervous system (CNS) stimulant of the phenethylamine class.

<span class="mw-page-title-main">Dextropropoxyphene</span> Withdrawn opioid medication

Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. It is still available in Australia, albeit with restrictions after an application by its manufacturer to review its proposed banning. Its onset of analgesia is said to be 20–30 minutes and peak effects are seen about 1.5–2.0 hours after oral administration.

<span class="mw-page-title-main">Butabarbital</span> Chemical compound

Butabarbital is a prescription barbiturate sleep aid and anxiety medication. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia, relieving general anxiety and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its intermediate duration of action gives butabarbital an abuse potential slightly lower than secobarbital. Butabarbital can be hydrolyzed to Valnoctamide.

<span class="mw-page-title-main">Armodafinil</span> Eugeroic medication

Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil). It consists of only the (R)-(−)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. and was approved by the U.S. Food and Drug Administration (FDA) in June 2007. In 2016, the FDA granted Mylan rights for the first generic version of Cephalon's Nuvigil to be marketed in the U.S.

<span class="mw-page-title-main">Polysubstance use</span> Use of multiple psychoactive substances

Polysubstance use or poly drug use refers to the use of combined psychoactive substances. Polysubstance use may be used for entheogenic, recreational, or off-label indications, with both legal and illegal substances. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects, or tolerance, of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.

A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. Terms like "combination drug" or "combination drug product" can be common shorthand for an FDC product, although the latter is more precise if in fact referring to a mass-produced product having a predetermined combination of drugs and respective dosages. And it should also be distinguished from the term "combination product" in medical contexts, which without further specification can refer to products that combine different types of medical products—such as device/drug combinations as opposed to drug/drug combinations. When a combination drug product is a "pill", then it may also be a kind of "polypill" or combopill.

<span class="mw-page-title-main">Lisdexamfetamine</span> Central nervous system stimulant prodrug

Lisdexamfetamine, most commonly sold under the brand name Vyvanse and Elvanse among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults, and for moderate-to-severe binge eating disorder in adults. Lisdexamfetamine is taken by mouth. Its effects generally begin within two hours and last for up to 14 hours. In the United Kingdom, it is usually less preferred than methylphenidate for the treatment of children.

<span class="mw-page-title-main">Obetrol</span> Diet pill

Obetrol was the brand name of a drug combining several amphetamine salts indicated for the treatment of exogenous obesity. It was originally sold by the American company Obetrol Pharmaceuticals. Obetrol was a popular diet pill in America in the 1950s and 1960s.

Eskatrol was an amphetamine weight loss agent which was removed by the U.S. Food and Drug Administration (FDA) in 1981 after its manufacturer, SmithKline & French (SKF), failed to prove the therapeutic effectiveness (Emax) of the medication. At the time it was among the 200 most widely prescribed drugs in the United States. Others included Dexamyl and Desbutal pills. Eskatrol contained dextroamphetamine sulfate (Dexedrine) and prochlorperazine (Compazine), a typical antipsychotic.

<span class="mw-page-title-main">Levoamphetamine</span> CNS stimulant and isomer of amphetamine

Levoamphetamine is a central nervous system (CNS) stimulant known to increase wakefulness and concentration in association with decreased appetite and fatigue. Pharmaceuticals that contain levoamphetamine are currently indicated and prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), obesity, and narcolepsy in some countries.

Desbutal was a brand name drug by Abbott containing 5mg methamphetamine hydrochloride (Desoxyn) and 30mg pentobarbital sodium (Nembutal); a substituted amphetamine and a barbiturate combined within the same pill. Desbutal was marketed as an antidepressant as well as a medication for the treatment of obesity, narcolepsy, parkinsonism, and alcoholism, although it was commonly also prescribed off-label for miscellaneous ailments. It had a high abuse potential and is no longer manufactured.

Gordon A. Alles, was an American chemist and pharmacologist who did extensive research on the isolation and properties of insulin for the treatment of diabetics. He is also credited with discovering and publishing the physiological effects of amphetamine and methylenedioxyamphetamine (MDA). He is the first person to have prepared amphetamine sulfate, although not the amphetamine molecule. Alles first reported the physiological properties of amphetamine as a synthetic analog of ephedrine, and therefore received credit for this discovery. He enjoyed large royalties from Smith, Kline & French (SKF) because he sold his patent rights for amphetamine to the company and it enjoyed large sales. Several popular products sold by SKF contained amphetamine, including Benzedrine pills and inhalers, Dexedrine pills and Dexamyl tablets. Counterfeit drugs such as Profetamine appeared, aiming to circumvent Alles' 'weak' patent.

Amphetamine type stimulants (ATS) are a group of synthetic drugs that are chemical derivatives of the parent compound alpha-methylphenethylamine, also known as amphetamine. Common ATS includes amphetamine, methamphetamine, ephedrine, pseudoephedrine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxyethylamphetamine (MDEA). ATS when used illicitly has street names including ice, meth, crystal, crank, bennies, and speed. Within the group of amphetamine-type stimulants, there are also prescription drugs including mixed amphetamine salts, dextroamphetamine, and lisdexamfetamine.

References

  1. ↑ The Primrose To Drug, Charleston Sunday Gazette-Mail, March 28, 1965, p. 54.
  2. ↑ Owen, David (2005-05-06). "The effect of Prime Minister Anthony Eden's illness on his decision-making during the Suez crisis". QJM: An International Journal of Medicine. 98 (6): 387–402. doi: 10.1093/qjmed/hci071 . ISSN   1460-2393. PMID   15879438.
  3. ↑ Marking, Havana (16 November 2008). "Danger all ways". The Guardian. Guardian News and Media, Ltd. Retrieved 25 July 2021.
  4. ↑ Rasmussen, Nicolas (2008). On speed: the many lives of amphetamine. New York: New York University Press. pp. 172–173. ISBN   9780814777350. OCLC   232956890.
  5. ↑ Schmeck, Harold M. (1973-04-02). "U. S. Sets Diet Drug Recall In Drive on Amphetamines". The New York Times . p. 73. ISSN   0362-4331 . Retrieved 2018-04-25.
  6. ↑ Himes, Chester B. (1998). My life of absurdity: the autobiography of Chester Himes. New York: Thunder's Mouth Press. p. 19. ISBN   978-1560250944. OCLC   39384647.
  7. ↑ Barceloux, Donald G. (2012). Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, NJ: John Wiley & Sons. p. 468. doi:10.1002/9781118105955. ISBN   9781118105955. OCLC   779616852. S2CID   70545709.
  8. ↑ "Charges dismissed in Phils' drug case". The New York Times. Associated Press. 5 February 1981. p. B7. Retrieved 2018-04-25.
  9. ↑ Stephenson, Will (March 22, 2016). "Nights of Terror, Days of Weird". Oxford American. Retrieved 2018-04-25.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.