Donna R. Maglott

Last updated
Donna R. Maglott
Alma materUniversity of Michigan
Scientific career
InstitutionsNational Center for Biotechnology Information
Thesis The structure and function of the 50S ribosome of Escherichia coli  (1970)

Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.

Contents

Education and career

Maglott earned her Ph.D. in 1970 from the University of Michigan where she worked on the 50S ribosome in the bacterium Escherichia coli. [1] She held an academic position at Howard University;[ when? ] and then moved to the American Type Culture Center in 1986 where she began establishing databases needed for genomic research. [2] [3] She started at the National Center for Biotechnology Information (NCBI) in 1998. [4]

Research

While at Howard University, Maglott worked on protein synthesis during early development of sea urchins. [5] [6] At ATCC, she worked on repositories holding clone and genomic information [7] [8] and began research using genomic tools to investigate information on human chromosomes. [9] [10] In 2000, Maglott worked with Kim D. Pruitt to introduce RefSeq, a web-based resource for gene-based information that is hosted by NCBI [11] [12] and has been updated over the years. [13] [14] She has also been involved in the development of other databases at NCBI including Entrez Gene, [15] [16] ClinVar, [17] [18] STS markers, Conserved CoDing Sequences (CCDS), Map Viewer, RefSeqGene, the NIH Genetic Testing Registry (GTR), MedGen, and ClinVar. [4] Large-scale genomics projects that Margott has worked on include the rat genome database, [19] and the mouse genome [20] [21] and transcriptome. [22] In 2006, Maglott was a part of the team analyzing the genome of the sea urchin, Strongylocentrotus purpuratus , which was the first genome obtained for a motile marine invertebrate. [23] [24]

Selected publications

Related Research Articles

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References

  1. ↑ Maglott, Donna Rae Schneider (1970). The structure and function of the 50S ribosome of Escherichia coli (Thesis). Ann Arbor - Mich. OCLC   633231185.
  2. ↑ "Center for Bioinformatics and Computational Biology". www.cbcb.umd.edu. 2006. Archived from the original on 2007-08-17. Retrieved 2021-10-02.
  3. ↑ "Donna Maglott, PhD - ClinGen | Clinical Genome Resource". 2017-07-10. Archived from the original on 2017-07-10. Retrieved 2021-10-02.
  4. 1 2 "Human Variome Project". www.humanvariomeproject.org. Retrieved 2016-12-18.
  5. ↑ Maglott, D.R. (1985). "Dissociation of cells from sea urchin embryos alters the synthesis of actins and other proteins". Cell Differentiation. 17 (1): 29–43. doi:10.1016/0045-6039(85)90535-4. PMID   3875415.
  6. ↑ Maglott, D.R. (1985). "Two-dimensional electrophoretic analysis of major phosphoproteins of the sea urchin, Arbacia punctulata". Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 80 (3): 513–516. doi:10.1016/0305-0491(85)90282-2. PMID   4006443.
  7. ↑ Maglott, Donna R.; Nierman, William C. (1990-11-01). "Clone and genomic repositories at the American Type Culture Collection". Genomics. 8 (3): 601–605. doi:10.1016/0888-7543(90)90054-X. ISSN   0888-7543. PMID   1981058.
  8. ↑ Maglott, Donna R.; Nierman, William C. (1991). "Mammalian probes and libraries at the ATCC". Mammalian Genome. 1 (1): 59–64. doi:10.1007/BF00350848. ISSN   0938-8990. PMID   1794047. S2CID   12336955.
  9. ↑ Scott Durkin, A.; Maglott, Donna R.; Nierman, William C. (1992-11-01). "Chromosomal assignment of 38 human brain expressed sequence tags (ESTs) by analyzing fluorescently labeled PCR products from hybrid cell panels". Genomics. 14 (3): 808–810. doi:10.1016/S0888-7543(05)80194-6. ISSN   0888-7543. PMID   1427913.
  10. ↑ Schmidt, Valentina A.; Nierman, William C.; Maglott, Donna R.; Cupit, Lisa D.; Moskowitz, Keith A.; Wainer, Jean Ann; Bahou, Wadie F. (1998). "The Human Proteinase-activated Receptor-3 (PAR-3) Gene". Journal of Biological Chemistry. 273 (24): 15061–15068. doi: 10.1074/jbc.273.24.15061 . ISSN   0021-9258. PMID   9614115.
  11. ↑ Maglott, D. R. (2000-01-01). "NCBI's LocusLink and RefSeq". Nucleic Acids Research. 28 (1): 126–128. doi:10.1093/nar/28.1.126. PMC   102393 . PMID   10592200.
  12. ↑ Pruitt, Kim D.; Katz, Kenneth S.; Sicotte, Hugues; Maglott, Donna R. (2000). "Introducing RefSeq and LocusLink: curated human genome resources at the NCBI". Trends in Genetics. 16 (1): 44–47. doi:10.1016/S0168-9525(99)01882-X. PMID   10637631.
  13. ↑ Pruitt, K. D. (2001-01-01). "RefSeq and LocusLink: NCBI gene-centered resources". Nucleic Acids Research. 29 (1): 137–140. doi:10.1093/nar/29.1.137. PMC   29787 . PMID   11125071.
  14. ↑ Pruitt, K. D.; Tatusova, T.; Maglott, D. R. (2007-01-03). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins". Nucleic Acids Research. 35 (Database): D61–D65. doi:10.1093/nar/gkl842. ISSN   0305-1048. PMC   1716718 . PMID   17130148.
  15. ↑ Maglott, D. (2004-12-17). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 33 (Database issue): D54–D58. doi:10.1093/nar/gki031. ISSN   1362-4962. PMC   539985 . PMID   15608257.
  16. ↑ Maglott, D.; Ostell, J.; Pruitt, K. D.; Tatusova, T. (2011-01-01). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 39 (Database): D52–D57. doi:10.1093/nar/gkq1237. ISSN   0305-1048. PMC   3013746 . PMID   21115458.
  17. ↑ Landrum, Melissa J; Lee, Jennifer M; Benson, Mark; Brown, Garth R; Chao, Chen; Chitipiralla, Shanmuga; Gu, Baoshan; Hart, Jennifer; Hoffman, Douglas; Jang, Wonhee; Karapetyan, Karen (2018-01-04). "ClinVar: improving access to variant interpretations and supporting evidence". Nucleic Acids Research. 46 (D1): D1062–D1067. doi:10.1093/nar/gkx1153. ISSN   0305-1048. PMC   5753237 . PMID   29165669.
  18. ↑ Landrum, Melissa J.; Lee, Jennifer M.; Riley, George R.; Jang, Wonhee; Rubinstein, Wendy S.; Church, Deanna M.; Maglott, Donna R. (2014). "ClinVar: public archive of relationships among sequence variation and human phenotype". Nucleic Acids Research. 42 (D1): D980–D985. doi:10.1093/nar/gkt1113. ISSN   0305-1048. PMC   3965032 . PMID   24234437.
  19. ↑ Twigger, S. (2002-01-01). "Rat Genome Database (RGD): mapping disease onto the genome". Nucleic Acids Research. 30 (1): 125–128. doi:10.1093/nar/30.1.125. PMC   99132 . PMID   11752273.
  20. ↑ Mouse Genome Sequencing Consortium (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode:2002Natur.420..520W. doi: 10.1038/nature01262 . ISSN   0028-0836. PMID   12466850.
  21. ↑ Hudson, Thomas J.; Church, Deanna M.; Greenaway, Simon; Nguyen, Huy; Cook, April; Steen, Robert G.; Van Etten, William J.; Castle, Andrew B.; Strivens, Mark A.; Trickett, Pamela; Heuston, Christine (2001). "A radiation hybrid map of mouse genes". Nature Genetics. 29 (2): 201–205. doi:10.1038/ng1001-201. ISSN   1061-4036. PMID   11586302. S2CID   27643522.
  22. ↑ The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team* (2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs". Nature. 420 (6915): 563–573. Bibcode:2002Natur.420..563O. doi: 10.1038/nature01266 . ISSN   0028-0836. PMID   12466851. S2CID   4347839.
  23. ↑ Sea Urchin Genome Sequencing Consortium; Sodergren, E.; Weinstock, G. M.; Davidson, E. H; Cameron, R. A.; Gibbs, R. A.; Angerer, R. C.; Angerer, L. M.; Arnone, M. I.; Burgess, D. R.; Burke, R. D. (2006-11-10). "The Genome of the Sea Urchin Strongylocentrotus purpuratus". Science. 314 (5801): 941–952. Bibcode:2006Sci...314..941S. doi:10.1126/science.1133609. ISSN   0036-8075. PMC   3159423 . PMID   17095691.
  24. ↑ Livingston, B.T.; Killian, C.E.; Wilt, F.; Cameron, A.; Landrum, M.J.; Ermolaeva, O.; Sapojnikov, V.; Maglott, D.R.; Buchanan, A.M.; Ettensohn, C.A. (2006). "A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus". Developmental Biology. 300 (1): 335–348. doi: 10.1016/j.ydbio.2006.07.047 . PMID   16987510.
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