Kim D. Pruitt

Last updated
Kim D. Pruitt
Kim D. Pruitt.png
Born1961 (age 62–63)
Alma mater Cornell University (PhD)
Known for RefSeq
Children2
Scientific career
FieldsBioinformatics
Institutions National Center for Biotechnology Information
Thesis Structure and expression of the Petunia mitochondrial S-PCF locus and cytochrome oxidase subunit II genes  (1990)
Doctoral advisor Maureen Hanson

Kim Dixon Pruitt (born 1961) is an American bioinformatician. She is chief of the information engineering branch at the National Center for Biotechnology Information. Pruitt led the development of the RefSeq gene database.

Contents

Education

Pruitt began her doctoral research in 1983. Her mentor was Maureen Hanson. [1] Pruitt completed a Ph.D. in genetics from Cornell University. [2] Her 1990 dissertation was titled Structure and expression of the Petunia mitochondrial S-PCF locus and cytochrome oxidase subunit II genes. [3] After seeing a Science interview of James M. Ostell at the National Center for Biotechnology Information (NCBI) about bioinformatics, Pruitt began working as a postdoctoral fellow at the United States National Library of Medicine (NLM). While completing her research, Pruitt approached Ostell and asked if she could work for him part-time while she was there. As a result, the following year and half from spring 1997 until mid-1998 Pruitt basically had two postdoctoral fellowships. [1]

Career

Pruitt joined the NLM in 1998. [4] Ostell hired Pruitt to develop a new project to keep track of curated sequences for the human genome. This program developed into a database of genes known as RefSeq and was released to the public in the Spring of 1999. By 2016, Pruitt managed a team of 22 scientists and worked closely with computer programmers and other teams who supported specific portions of the RefSeq data set. Pruitt's group curated data and created sequence records for humans, animals, plants, fungi, and bacteria. Her curation team expanded significantly between 2012 and 2016 to now support everything except the viruses. [1]

In 2017, she became acting chief of the information engineering branch (IEB) at NCBI, where she established a production services operating board to communicate on the status and future directions of critical services, including PubMed, PubMed Central, PubChem, ClinicalTrials.gov, GenBank, BLAST, Pathogen Detection, ClinVar, and dbGaP. This effort led to notable changes to guide and inform product decisions and development priorities. [4]

In 2019, Pruitt became chief of the IEB. As chief, Pruitt is responsible for NCBI's collection, creation, analysis, organization, curation, and dissemination of data and analysis tools in the areas of molecular biology and genetics, as well as for the collection and management of bibliographic information. Pruitt leads NCBI's more than 500 highly skilled scientific and technical staff in the design, development, and maintenance of databases, information systems, and software tools, as well as operational management of data submissions, quality checks, and data access. Pruitt's appointment was lauded by NLM director Patricia Flatley Brennan and NCBI director James M. Ostell. [4]

Personal life

Pruitt is married and has two daughters. [1]

Related Research Articles

<span class="mw-page-title-main">National Center for Biotechnology Information</span> Database branch of the US National Library of Medicine

The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States. The NCBI is located in Bethesda, Maryland, and was founded in 1988 through legislation sponsored by US Congressman Claude Pepper.

The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations. It is produced and maintained by the National Center for Biotechnology Information as part of the International Nucleotide Sequence Database Collaboration (INSDC).

<span class="mw-page-title-main">David J. Lipman</span> American biologist

David J. Lipman is an American biologist who from 1989 to 2017 was the director of the National Center for Biotechnology Information (NCBI) at the National Institutes of Health. NCBI is the home of GenBank, the U.S. node of the International Sequence Database Consortium, and PubMed, one of the most heavily used sites in the world for the search and retrieval of biomedical information. Lipman is one of the original authors of the BLAST sequence alignment program, and a respected figure in bioinformatics. In 2017, he left NCBI and became Chief Science Officer at Impossible Foods.

<span class="mw-page-title-main">COX4I1</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) is an enzyme that in humans is encoded by the COX4I1 gene. COX4I1 is a nuclear-encoded isoform of cytochrome c oxidase (COX) subunit 4. Cytochrome c oxidase is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane, acting as the terminal enzyme of the mitochondrial respiratory chain. Antibodies against COX4 can be used to identify the inner membrane of mitochondria in immunofluorescence studies. Mutations in COX4I1 have been associated with COX deficiency and Fanconi anemia.

<span class="mw-page-title-main">COX4I2</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial is an enzyme that in humans is encoded by the COX4I2 gene. COX4I2 is a nuclear-encoded isoform of cytochrome c oxidase (COX) subunit 4. Cytochrome c oxidase is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane, acting as the terminal enzyme of the mitochondrial respiratory chain. Mutations in COX4I2 have been associated with exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis (EPIDACH).

<span class="mw-page-title-main">COX6B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 6B1 is an enzyme that in humans is encoded by the COX6B1 gene. Cytochrome c oxidase 6B1 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain. Mutations of the COX6B1 gene are associated with severe infantile encephalomyopathy and mitochondrial complex IV deficiency (MT-C4D).

The Reference Sequence (RefSeq) database is an open access, annotated and curated collection of publicly available nucleotide sequences and their protein products. RefSeq was introduced in 2000. This database is built by National Center for Biotechnology Information (NCBI), and, unlike GenBank, provides only a single record for each natural biological molecule for major organisms ranging from viruses to bacteria to eukaryotes.

<span class="mw-page-title-main">COX5B</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 5B, mitochondrial is an enzyme in humans that is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain. In humans, cytochrome c oxidase subunit 5B is encoded by the COX5B gene.

<span class="mw-page-title-main">COX6A1</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 6A1, mitochondrial is a protein that in humans is encoded by the COX6A1 gene. Cytochrome c oxidase 6A1 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain. A mutation of the COX6A1 gene is associated with a recessive axonal or mixed form of Charcot-Marie-Tooth disease.

<span class="mw-page-title-main">COX7A1</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.

<span class="mw-page-title-main">COX7B</span> Protein-coding gene in humans

Cytochrome c oxidase subunit 7B, mitochondrial (COX7B) is an enzyme that in humans is encoded by the COX7B gene. COX7B is a nuclear-encoded subunit of cytochrome c oxidase (COX). Cytochrome c oxidase is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane, acting as the terminal enzyme of the mitochondrial respiratory chain. Work with Oryzias latices has linked disruptions in COX7B with microphthalmia with linear skin lesions (MLS), microcephaly, and mitochondrial disease. Clinically, mutations in COX7B have been associated with linear skin defects with multiple congenital anomalies.

<span class="mw-page-title-main">COX6C</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.

Mitochondrially encoded tRNA threonine also known as MT-TT is a transfer RNA which in humans is encoded by the mitochondrial MT-TT gene.

The Consensus Coding Sequence (CCDS) Project is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies. The CCDS project tracks identical protein annotations on the reference mouse and human genomes with a stable identifier, and ensures that they are consistently represented by the National Center for Biotechnology Information (NCBI), Ensembl, and UCSC Genome Browser. The integrity of the CCDS dataset is maintained through stringent quality assurance testing and on-going manual curation.

<span class="mw-page-title-main">COX5A</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 5a is a protein that in humans is encoded by the COX5A gene. Cytochrome c oxidase 5A is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.

<span class="mw-page-title-main">COX6A2</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit VIa polypeptide 2 is a protein that in humans is encoded by the COX6A2 gene. Cytochrome c oxidase 6A2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.

<span class="mw-page-title-main">COX6B2</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.

<span class="mw-page-title-main">COX8A</span> Protein-coding gene in the species Homo sapiens

Cytochrome c oxidase subunit 8A (COX8A) is a protein that in humans is encoded by the COX8A gene. Cytochrome c oxidase 8A is a subunit of the cytochrome c oxidase complex, also known as Complex IV. Mutations in the COX8A gene have been associated with complex IV deficiency with Leigh syndrome and epilepsy.

Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.

<span class="mw-page-title-main">COX18, cytochrome c oxidase assembly factor</span> Protein-coding gene in the species Homo sapiens

COX18, cytochrome c oxidase assembly factor is a protein that in humans is encoded by the COX18 gene.

References

  1. 1 2 3 4 "Focus on NLM Scientists: Kim Pruitt Has Built a Career on Passion and Persistence". NLM in Focus. 2016-10-04. Retrieved 2020-04-14.
  2. ↑ Medicine (U.S.) (1997). National Library of Medicine Programs and Services. The Library. p. 61.
  3. ↑ Pruitt, Kim Dixon (1990). Structure and expression of the Petunia mitochondrial S-PCF locus and cytochrome oxidase subunit II genes. OCLC   693160009.
  4. 1 2 3 "Kim D. Pruitt, PhD, Appointed Chief, Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine". National Library of Medicine. December 2019. Retrieved 2020-04-14.
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