Dynein, axonemal, heavy chain 14

DNAH14
Identifiers
Aliases	DNAH14 , C1orf67, Dnahc14, HL-18, HL18, dynein axonemal heavy chain 14
External IDs	MGI: 2444525 HomoloGene: 90078 GeneCards: DNAH14
Gene location (Human)
Chr.	Chromosome 1 (human) [1]
End	225,399,292 bp [1]
Gene ontology
Molecular function	• microtubule motor activity ; • nucleotide binding ; • motor activity ; • ATP binding ; • ATP-dependent microtubule motor activity, minus-end-directed ; • dynein light chain binding ; • dynein intermediate chain binding ; • dynein light intermediate chain binding ;
Cellular component	• cytoplasm ; • cell projection ; • microtubule ; • cytoskeleton ; • Butt ; • dynein complex ;
Biological process	• microtubule-based movement ; • cilium morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	127602
	240960
	ENSG00000185842
	n/a
	Q0VDD8
	n/a
	NM_001145154 ; NM_001373 ; NM_144989 ; NM_001349911 ; NM_001349912
	NM_172846
	NP_001138626 ; NP_001364 ; NP_659426 ; NP_001336840 ; NP_001336841
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 26, 2019

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene.^[4]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Function

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Dynein, axonemal, heavy chain 14".
↑ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[entrez-4] "Entrez Gene: Dynein, axonemal, heavy chain 14".

[5] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.