ECD (gene)

ECD
Identifiers
Aliases	ECD , GCR2, HSGT1, SGT1, ecdysoneless cell cycle regulator
External IDs	OMIM: 616464; MGI: 1917851; HomoloGene: 5256; GeneCards: ECD; OMA:ECD - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.2 Start 73,130,155 bp [1] End 73,169,055 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 20,369,920 bp [2] End 20,398,189 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon islet of Langerhans ganglionic eminence tendon of biceps brachii popliteal artery tibial arteries ventricular zone testicle stromal cell of endometrium Top expressed in internal carotid artery external carotid artery Rostral migratory stream fetal liver hematopoietic progenitor cell spermatocyte epiblast primitive streak hair follicle lacrimal gland parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding histone acetyltransferase binding Cellular component cytoplasm nucleus nucleoplasm R2TP complex cytosol Biological process regulation of G1/S transition of mitotic cell cycle cell population proliferation regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of glycolytic process positive regulation of transcription by RNA polymerase II RNA splicing mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11319 70601 Ensembl ENSG00000122882 ENSMUSG00000021810 UniProt O95905 Q9CS74 RefSeq (mRNA) NM_001135752 NM_001135753 NM_007265 NM_027475 RefSeq (protein) NP_001129224 NP_001129225 NP_009196 NP_081751 Location (UCSC) Chr 10: 73.13 – 73.17 Mb Chr 14: 20.37 – 20.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SGT1 is a protein that in humans is encoded by the ECD gene. ^{[5] [6] [7]}

Clinical significane

ECD expression has been linked to lower survival rates for lung adenocarcinoma patients. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000122882 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021810 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sato T, Jigami Y, Suzuki T, Uemura H (Feb 1999). "A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae". Mol Gen Genet. 260 (6): 535–40. doi:10.1007/s004380050926. PMID   9928932. S2CID   28511451.
6. Gaziova I, Bonnette PC, Henrich VC, Jindra M (May 2004). "Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis". Development. 131 (11): 2715–25. doi: 10.1242/dev.01143 . PMID   15128659.
7. "Entrez Gene: ECD ecdysoneless homolog (Drosophila)".
8. "Research Update from the MCM Team (July 2025)". World Community Grid. 14 July 2025. Retrieved 16 July 2025.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bork JM, Peters LM, Riazuddin S, et al. (2001). "Usher Syndrome 1D and Nonsyndromic Autosomal Recessive Deafness DFNB12 Are Caused by Allelic Mutations of the Novel Cadherin-Like Gene CDH23". Am. J. Hum. Genet. 68 (1): 26–37. doi:10.1086/316954. PMC   1234923 . PMID   11090341.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nowotny M, Spiechowicz M, Jastrzebska B, et al. (2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. 278 (29): 26923–8. doi: 10.1074/jbc.M211518200 . PMID   12746458.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.