EDEM3

EDEM3
Identifiers
Aliases	EDEM3 , C1orf22, ER degradation enhancing alpha-mannosidase like protein 3, CDG2V
External IDs	OMIM: 610214; MGI: 1914217; HomoloGene: 11866; GeneCards: EDEM3; OMA:EDEM3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.3 Start 184,690,237 bp [1] End 184,754,907 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 G2 Start 151,631,122 bp [2] End 151,697,802 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus mucosa of sigmoid colon jejunal mucosa mucosa of paranasal sinus trabecular bone islet of Langerhans stromal cell of endometrium cardia body of pancreas rectum Top expressed in lacrimal gland seminal vesicula salivary gland parotid gland submandibular gland cumulus cell left lung lobe pineal gland epithelium of stomach crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding hydrolase activity metal ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment Biological process endoplasmic reticulum unfolded protein response protein glycosylation N-glycan processing response to unfolded protein glycoprotein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process mannose trimming involved in glycoprotein ERAD pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80267 66967 Ensembl ENSG00000116406 ENSMUSG00000043019 UniProt Q9BZQ6 Q2HXL6 RefSeq (mRNA) NM_025191 NM_001319960 NM_001039644 NM_001311165 NM_001311166 RefSeq (protein) NP_001306889 NP_079467 NP_001034733 NP_001298094 NP_001298095 Location (UCSC) Chr 1: 184.69 – 184.75 Mb Chr 1: 151.63 – 151.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000116406 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043019 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID   15537790.
6. Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi: 10.1074/jbc.C400534200 . PMID   15579471.
7. "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID   11318611.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi: 10.1074/jbc.M512191200 . PMID   16431915.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.