EIF5AP1

EIF5AL1
Identifiers
Aliases	EIF5AL1 , EIF5AP1, bA342M3.3, eukaryotic translation initiation factor 5A-like 1, EIF5A, eIF-5A, eIF-5A1, eIF-4D, eIF-5A-1, eukaryotic translation initiation factor 5A like 1
External IDs	HomoloGene: 100947 GeneCards: EIF5AL1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,516,440 bp
RNA expression pattern
	Top expressed in
	testicle; ; thymus; ; stromal cell of endometrium; ; bone marrow cells; ; liver; ; gastrocnemius muscle; ; right lobe of liver; ; skeletal muscle tissue; ; ganglionic eminence; ; cerebellum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	translation elongation factor activity ; RNA binding ; ribosome binding ;
Cellular component	nuclear pore ; endoplasmic reticulum membrane ; nucleus ; membrane ; cytoplasm ; endoplasmic reticulum ;
Biological process	protein transport ; translational frameshifting ; positive regulation of translational elongation ; translational elongation ; mRNA transport ; protein biosynthesis ; positive regulation of translational termination ;
	Sources:Amigo / QuickGO
Orthologs
	143244
	n/a
	ENSG00000253626
	n/a
	Q6IS14
	n/a
	NM_001099692
	n/a
	NP_001093162
	n/a
	Wikidata
View/Edit Human

Last updated October 18, 2022

Eukaryotic translation initiation factor 5A pseudogene 1, also known as EIF5AP1, is a human gene.^[3]

Related Research Articles

Hypusine is an uncommon amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known proteins containing the hypusine residue is eukaryotic translation initiation factor 5A (eIF-5A) and a similar protein found in archaea. In humans, two isoforms of eIF-5A have been described: eIF5A-1 and eIF5A-2. They are encoded by two distinct genes EIF5A and EIF5A2. The protein is involved in protein biosynthesis and promotes the formation of the first peptide bond. The region surrounding the hypusine residue is highly conserved and is essential to the function of eIF5A. Thus, hypusine and eIF-5A appear to be vital for the viability and proliferation of eukaryotic cells.

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene.

Eukaryotic translation initiation factor 4 gamma 2 is a protein that in humans is encoded by the EIF4G2 gene.

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000253626 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EIF5AP1 eukaryotic translation initiation factor 5A pseudogene 1".

Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–618. doi: 10.1016/j.molcel.2006.06.026 . PMID 16916647.
Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells". FEBS J. 273 (6): 1102–1114. doi:10.1111/j.1742-4658.2006.05135.x. PMC 4406228 . PMID 16519677.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Facchiano AM, Stiuso P, Chiusano ML, et al. (2002). "Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A)". Protein Eng. 14 (11): 881–890. doi: 10.1093/protein/14.11.881 . PMID 11742107.
Lipowsky G, Bischoff FR, Schwarzmaier P, et al. (2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–4371. doi:10.1093/emboj/19.16.4362. PMC 302028 . PMID 10944119.
Ruhl M, Himmelspach M, Bahr GM, et al. (1994). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation". J. Cell Biol. 123 (6 Pt 1): 1309–1320. doi:10.1083/jcb.123.6.1309. PMC 2290910 . PMID 8253832.
Steinkasserer A, Jones T, Sheer D, et al. (1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.
Koettnitz K, Wöhl T, Kappel B, et al. (1995). "Identification of a new member of the human eIF-5A gene family". Gene. 159 (2): 283–284. doi:10.1016/0378-1119(95)00136-T. PMID 7622067.
Koettnitz K, Kappel B, Baumruker T, et al. (1994). "The genomic structure encoding human initiation factor eIF-5A". Gene. 144 (2): 249–252. doi:10.1016/0378-1119(94)90385-9. PMID 7545941.
Park MH, Liu TY, Neece SH, Swiggard WJ (1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue". J. Biol. Chem. 261 (31): 14515–9. doi: 10.1016/S0021-9258(18)66899-1 . PMID 3095320.
Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein". J. Biol. Chem. 264 (3): 1578–83. doi: 10.1016/S0021-9258(18)94226-2 . PMID 2492279.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000253626 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: EIF5AP1 eukaryotic translation initiation factor 5A pseudogene 1".

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[2]

[3]

EIF5AP1

Related Research Articles

References

Further reading