EPS8L2

EPS8L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWU, 1WXB
Identifiers
Aliases	EPS8L2 , EPS8R2, EPS8 like 2, DFNB106
External IDs	OMIM: 614988 MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	727,727 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,942,933 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; minor salivary gland; ; right lobe of liver; ; right uterine tube; ; skin of abdomen; ; amniotic fluid; ; body of pancreas; ; right lung; ; sural nerve;
	Top expressed in
	intestinal villus; ; esophagus; ; lip; ; duodenum; ; yolk sac; ; ileum; ; jejunum; ; pyloric antrum; ; Epithelium of stomach; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding ; cadherin binding ; protein binding ;
Cellular component	ruffle membrane ; vesicle ; plasma membrane ; extracellular exosome ; cytoplasm ; cytosol ; stereocilium bundle ; stereocilium tip ; stereocilium ; protein-containing complex ; cell projection ;
Biological process	regulation of Rho protein signal transduction ; Rho protein signal transduction ; positive regulation of ruffle assembly ; sensory perception of sound ; regulation of molecular function ;
	Sources:Amigo / QuickGO
Orthologs
	64787
	98845
	ENSG00000177106
	ENSMUSG00000025504
	Q9H6S3
	Q99K30
	NM_022772
	NM_133191
	NP_073609
	NP_573454
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.^[5]^[6]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.^[6]

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<span class="mw-page-title-main">EIF1B</span>

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177106 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025504 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
1 2 "Entrez Gene: EPS8L2 EPS8-like 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530 . PMID 14565974.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177106 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025504 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12620401-5] Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.

[entrez-6] 1 2 "Entrez Gene: EPS8L2 EPS8-like 2".

[1]

[2]

[3]

[4]

[5]

[6]

EPS8L2

Related Research Articles

References

Further reading