EPS8L3

EPS8L3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXT
Identifiers
Aliases	EPS8L3 , EPS8R3, EPS8 like 3, HYPT5
External IDs	OMIM: 614989 MGI: 2139743 HomoloGene: 15878 GeneCards: EPS8L3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,750,080 bp [1] End 109,764,027 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.3 Start 107,784,545 bp [2] End 107,800,216 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum gallbladder jejunal mucosa duodenum gastric mucosa pancreatic ductal cell appendix body of stomach pylorus sperm Top expressed in intestinal villus ileum duodenum large intestine colon jejunum left colon crypt of lieberkuhn of small intestine mucous cell of stomach seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin filament binding actin binding Cellular component cytoplasm plasma membrane ruffle membrane Biological process regulation of hair cycle Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79574 99662 Ensembl ENSG00000198758 ENSMUSG00000040600 UniProt Q8TE67 Q91WL0 RefSeq (mRNA) NM_024526 NM_133181 NM_139053 NM_001319952 NM_133867 RefSeq (protein) NP_001306881 NP_078802 NP_573444 NP_620641 NP_598628 Location (UCSC) Chr 1: 109.75 – 109.76 Mb Chr 3: 107.78 – 107.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene. ^{[5] [6]}

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198758 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040600 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID   12620401.
6. "Entrez Gene: EPS8L3 EPS8-like 3".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC   307530 . PMID   14565974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.