ESX1

ESX1
Identifiers
Aliases	ESX1 , ESX1L, ESXR1, ESX homeobox 1
External IDs	OMIM: 300154 HomoloGene: 49152 GeneCards: ESX1
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.2 Start 104,250,038 bp [1] End 104,254,933 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta endometrium human musculoskeletal system muscular system muscle of leg ovary lower leg gastrocnemius muscle abdominal fat abdominal wall n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm nuclear speck Biological process negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80712 n/a Ensembl ENSG00000123576 n/a UniProt Q8N693 n/a RefSeq (mRNA) NM_153448 n/a RefSeq (protein) NP_703149 n/a Location (UCSC) Chr X: 104.25 – 104.25 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000123576 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Fohn LE, Behringer RR (May 2001). "ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis". Genomics. 74 (1): 105–8. doi:10.1006/geno.2001.6532. PMID   11374906.
4. Loschiavo M, Nguyen QK, Duselis AR, Vrana PB (Feb 2007). "Mapping and identification of candidate loci responsible for Peromyscus hybrid overgrowth". Mamm Genome. 18 (1): 75–85. doi:10.1007/s00335-006-0083-x. PMC   1794137 . PMID   17242862.
5. "Entrez Gene: ESX1 extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)".

Further reading

• Murthi P, Doherty VL, Said JM, et al. (2006). "Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction". Mol. Hum. Reprod. 12 (5): 335–40. doi: 10.1093/molehr/gal037 . PMID   16613891.
• Figueiredo AL, Salles MG, Albano RM, Porto LC (2005). "Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development". J. Cell. Mol. Med. 8 (4): 545–50. doi:10.1111/j.1582-4934.2004.tb00479.x. PMC   6740265 . PMID   15601583.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ozawa H, Ashizawa S, Naito M, et al. (2004). "Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation". Oncogene. 23 (39): 6590–602. doi: 10.1038/sj.onc.1207884 . PMID   15235584.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.