EXPH5

EXPH5
Identifiers
Aliases	EXPH5 , SLAC2-B, SLAC2B, exophilin 5, EBS4
External IDs	OMIM: 612878; MGI: 2443248; HomoloGene: 9007; GeneCards: EXPH5; OMA:EXPH5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q22.3 Start 108,505,435 bp [1] End 108,593,768 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.3 Start 53,212,970 bp [2] End 53,288,814 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip mucosa of paranasal sinus amniotic fluid oral cavity skin of thigh bronchial epithelial cell skin of arm nipple nasal epithelium gums Top expressed in cerebellar cortex jejunum zone of skin liver ileum esophagus lip stomach spermatocyte lung More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23086 320051 Ensembl ENSG00000110723 ENSMUSG00000034584 UniProt Q8NEV8 Q0VAV2 RefSeq (mRNA) NM_001144763 NM_001144764 NM_001144765 NM_001308019 NM_015065 NM_176846 RefSeq (protein) NP_001138235 NP_001138236 NP_001138237 NP_001294948 NP_055880 NP_789816 Location (UCSC) Chr 11: 108.51 – 108.59 Mb Chr 9: 53.21 – 53.29 Mb PubMed search [3] [4]
Wikidata
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Exophilin 5, also known as EXPH5, is a human gene. ^[5]

Interactions

EXPH5 has been shown to interact with RAB27A. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000110723 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034584 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EXPH5 exophilin 5".
6. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID   11773082.

Further reading

• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi: 10.1074/jbc.M213090200 . PMID   12590134.
• Fukuda M (2002). "Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A". J. Biol. Chem. 277 (42): 40118–24. doi: 10.1074/jbc.M205765200 . PMID   12189142.
• Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. Bibcode:2002FEBSL.517..233N. doi: 10.1016/S0014-5793(02)02634-0 . PMID   12062444. S2CID   14844547.
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID   11773082.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.