EXPH5

EXPH5
Identifiers
Aliases	EXPH5 , SLAC2-B, SLAC2B, exophilin 5, EBS4
External IDs	OMIM: 612878; MGI: 2443248; HomoloGene: 9007; GeneCards: EXPH5; OMA:EXPH5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	108,593,768 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	53,288,814 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; mucosa of paranasal sinus; ; amniotic fluid; ; oral cavity; ; skin of thigh; ; bronchial epithelial cell; ; skin of arm; ; nipple; ; nasal epithelium; ; gums;
	Top expressed in
	cerebellar cortex; ; jejunum; ; zone of skin; ; liver; ; ileum; ; esophagus; ; lip; ; stomach; ; spermatocyte; ; lung;
	More reference expression data
	More reference expression data
Orthologs
	23086
	320051
	ENSG00000110723
	ENSMUSG00000034584
	Q8NEV8
	Q0VAV2
	NM_001144763 ; NM_001144764 ; NM_001144765 ; NM_001308019 ; NM_015065 Contents Interactions ; References ; Further reading ;
	NM_176846
	NP_001138235 ; NP_001138236 ; NP_001138237 ; NP_001294948 ; NP_055880
	NP_789816
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 03, 2024

Exophilin 5, also known as EXPH5, is a human gene.^[5]

Interactions

EXPH5 has been shown to interact with RAB27A.^[6]

Related Research Articles

Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

Synaptotagmin-like 2, also known as SYTL2, is a human gene.

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.

Ras-related protein Rab-40A is a protein that in humans is encoded by the RAB40A gene.

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene.

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000110723 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034584 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EXPH5 exophilin 5".
↑ Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID 11773082.

Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi: 10.1074/jbc.M213090200 . PMID 12590134.
Fukuda M (2002). "Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A". J. Biol. Chem. 277 (42): 40118–24. doi: 10.1074/jbc.M205765200 . PMID 12189142.
Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. Bibcode:2002FEBSL.517..233N. doi: 10.1016/S0014-5793(02)02634-0 . PMID 12062444. S2CID 14844547.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID 11773082.
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000110723 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034584 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EXPH5 exophilin 5".

[pmid11773082-6] Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID 11773082.

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EXPH5

Contents

Interactions

Related Research Articles

References

Further reading