EZH1

EZH1
Identifiers
Aliases	EZH1 , KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
External IDs	OMIM: 601674 MGI: 1097695 HomoloGene: 20458 GeneCards: EZH1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 42,700,275 bp [1] End 42,745,049 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 64.37 cM Start 101,081,941 bp [2] End 101,117,289 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere tibial nerve Achilles tendon sural nerve olfactory bulb canal of the cervix inferior olivary nucleus gastric mucosa subcutaneous adipose tissue right uterine tube Top expressed in ciliary body iris motor neuron retinal pigment epithelium ankle secondary oocyte cerebellar cortex spermatocyte submandibular gland lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity chromatin binding histone-lysine N-methyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding transcription corepressor activity Cellular component ESC/E(Z) complex nucleus nucleoplasm chromosome, telomeric region Biological process histone H3-K27 methylation anatomical structure morphogenesis methylation regulation of transcription, DNA-templated hippocampus development transcription, DNA-templated positive regulation of transcription by RNA polymerase II chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2145 14055 Ensembl ENSG00000108799 ENSMUSG00000006920 UniProt Q92800 P70351 RefSeq (mRNA) NM_001991 NM_001321079 NM_001321081 NM_001321082 NM_007970 RefSeq (protein) NP_001308008 NP_001308010 NP_001308011 NP_001982 NP_031996 NP_001390736 NP_001390738 NP_001390739 NP_001390740 NP_001390741 NP_001390742 NP_001390743 NP_001390744 NP_001390745 NP_001390747 NP_001390750 NP_001390751 Location (UCSC) Chr 17: 42.7 – 42.75 Mb Chr 11: 101.08 – 101.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene. ^{[5] [6]}

Function

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. ^[7] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (Feb 1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID   8921387.
6. "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)".
7. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E (Mar 2011). "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair". Genes Dev. 25 (5): 485–98. doi:10.1101/gad.2019811. PMC   3049289 . PMID   21317239.
8. Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH (Nov 2008). "EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency". Mol Cell. 32 (4): 491–502. doi:10.1016/j.molcel.2008.10.016. PMC   2630502 . PMID   19026780.

Further reading

• Rommens JM, Durocher F, McArthur J, et al. (1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID   7490091.
• Brody LC, Abel KJ, Castilla LH, et al. (1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5. PMID   7774924.
• Osborne-Lawrence S, Welcsh PL, Spillman M, et al. (1995). "Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21". Genomics. 25 (1): 248–55. doi:10.1016/0888-7543(95)80132-6. PMID   7774925.
• Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics. 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID   7774926.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
• Ogawa M, Hiraoka Y, Taniguchi K, Aiso S (1998). "Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2". Biochim. Biophys. Acta. 1395 (2): 151–8. doi:10.1016/s0167-4781(97)00156-5. PMID   9473645.
• Jones CA, Ng J, Peterson AJ, et al. (1998). "The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression". Mol. Cell. Biol. 18 (5): 2825–34. doi:10.1128/mcb.18.5.2825. PMC   110661 . PMID   9566901.
• van Lohuizen M, Tijms M, Voncken JW, et al. (1998). "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes". Mol. Cell. Biol. 18 (6): 3572–9. doi:10.1128/MCB.18.6.3572. PMC   108938 . PMID   9584197.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.