Elizabeth McGraw

Last updated
Beth McGraw
Born
Elizabeth Ann McGraw
Alma mater Pennsylvania State University
University of Michigan
Scientific career
Fields Symbiosis
Evolution
Vector:virus interactions
Wolbachia
Institutions Monash University
University of Queensland
Yale University
Pennsylvania State University
Thesis Molecular evolution of invasive bacterial pathogens  (1998)
Website www.huck.psu.edu/people/elizabeth-mcgraw OOjs UI icon edit-ltr-progressive.svg

Elizabeth Ann McGraw is an American biologist who is a professor in entomology at Pennsylvania State University. [1] [2] She is the Director of the Center for Infectious Disease Dynamics and a Huck Scholar in Entomology. Her research investigates the bacterium Wolbachia as a strategy for biocontrol and to better understand the basis of its interactions with insects. [3] [4] [5] She was elected a Fellow of the American Society for Microbiology.

Contents

Early life and education

McGraw was an undergraduate biology student at the University of Michigan.[ when? ] She moved to Pennsylvania State University where she studied the evolution of virulence genes in human pathogens and was awarded a PhD in 1998. [6]

Research and career

After her PhD, she joined Yale University for her postdoctoral research, where she studied the Wolbachia insect system. She was particularly interested in being able to ask questions about the evolution of mutualism. She moved to the University of Queensland as a postdoctoral researcher.

McGraw was appointed to the faculty at the University of Queensland, then moved to Monash University as a Larkins Fellow in 2011, where she studied how bacteria affect host biology and how insects invest in response to a symbiont. [7] She has extensively studied the endosymbiont Wolbachia . Wolbachia prevents harmful pathogens replicating inside mosquitos, which may offer hope for biocontrol against mosquito-borne diseases. [8] Her research showed that when Wolbachia was inside mosquitoes it could prevent viruses from replicating. [9] She showed that Dengue virus could not become resistant to Wolbachia, and that Dengue viruses grown with Wolbachia were less effective at infecting mosquito cells and were less able to replicate. [9] [10]

In 2017, McGraw joined Pennsylvania State University as a professor in entomology. [11]

Awards and honors

McGraw was elected Fellow of the American Society for Microbiology in 2023. [8]

Selected publications

Related Research Articles

<span class="mw-page-title-main">Yellow fever</span> Viral disease common in tropical Africa and South America

Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In about 15% of people, within a day of improving the fever comes back, abdominal pain occurs, and liver damage begins causing yellow skin. If this occurs, the risk of bleeding and kidney problems is increased.

<span class="mw-page-title-main">Mosquito</span> Family of flies

Mosquitoes are approximately 3,600 species of small flies comprising the family Culicidae. The word "mosquito" is Spanish for "little fly". Mosquitoes have a slender segmented body, one pair of wings, one pair of halteres, three pairs of long hair-like legs, and elongated mouthparts.

<span class="mw-page-title-main">Dengue fever</span> Tropical disease caused by the dengue virus, transmitted by mosquito

Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs.

<i>Aedes albopictus</i> Species of mosquito

Aedes albopictus, from the mosquito (Culicidae) family, also known as the (Asian) tiger mosquito or forest mosquito, is a mosquito native to the tropical and subtropical areas of Southeast Asia. In the past few centuries, however, this species has spread to many countries through the transport of goods and international travel. It is characterized by the white bands on its legs and body.

<span class="mw-page-title-main">Chikungunya</span> Infection caused by the Chikungunya virus

Chikungunya is an infection caused by the Chikungunya virus (CHIKV). Symptoms include fever and joint pains. These typically occur two to twelve days after exposure. Other symptoms may include headache, muscle pain, joint swelling, and a rash. Symptoms usually improve within a week; however, occasionally the joint pain may last for months or years. The risk of death is around 1 in 1,000. The very young, old, and those with other health problems are at risk of more severe disease.

<i>Wolbachia</i> Genus of bacteria in the Alphaproteobacteria class

Wolbachia is a genus of intracellular bacteria that infects mainly arthropod species, including a high proportion of insects, and also some nematodes. It is one of the most common parasitic microbes, and is possibly the most common reproductive parasite in the biosphere. Its interactions with its hosts are often complex, and in some cases have evolved to be mutualistic rather than parasitic. Some host species cannot reproduce, or even survive, without Wolbachia colonisation. One study concluded that more than 16% of neotropical insect species carry bacteria of this genus, and as many as 25 to 70% of all insect species are estimated to be potential hosts.

<i>Dengue virus</i> Species of virus

Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. Nevertheless, scientists' understanding of dengue virus may be simplistic as, rather than distinct antigenic groups, a continuum appears to exist. This same study identified 47 strains of dengue virus. Additionally, coinfection with and lack of rapid tests for Zika virus and chikungunya complicate matters in real-world infections.

<i>Aedes aegypti</i> Species of mosquito

Aedes aegypti, the yellow fever mosquito, is a mosquito that can spread dengue fever, chikungunya, Zika fever, Mayaro and yellow fever viruses, and other disease agents. The mosquito can be recognized by black and white markings on its legs and a marking in the form of a lyre on the upper surface of its thorax. This mosquito originated in Africa, but is now found in tropical, subtropical and temperate regions throughout the world.

<span class="mw-page-title-main">Mosquito control</span> Efforts to reduce damage from mosquitoes

Mosquito control manages the population of mosquitoes to reduce their damage to human health, economies, and enjoyment. Mosquito control is a vital public-health practice throughout the world and especially in the tropics because mosquitoes spread many diseases, such as malaria and the Zika virus.

Paratransgenesis is a technique that attempts to eliminate a pathogen from vector populations through transgenesis of a symbiont of the vector. The goal of this technique is to control vector-borne diseases. The first step is to identify proteins that prevent the vector species from transmitting the pathogen. The genes coding for these proteins are then introduced into the symbiont, so that they can be expressed in the vector. The final step in the strategy is to introduce these transgenic symbionts into vector populations in the wild. One use of this technique is to prevent mortality for humans from insect-borne diseases. Preventive methods and current controls against vector-borne diseases depend on insecticides, even though some mosquito breeds may be resistant to them. There are other ways to fully eliminate them. “Paratransgenesis focuses on utilizing genetically modified insect symbionts to express molecules within the vector that are deleterious to pathogens they transmit.” The acidic bacteria Asaia symbionts are beneficial in the normal development of mosquito larvae; however, it is unknown what Asais symbionts do to adult mosquitoes.

<span class="mw-page-title-main">Medical entomology</span> Study of insect impacts on human health

The discipline of medical entomology, or public health entomology, and also veterinary entomology is focused upon insects and arthropods that impact human health. Veterinary entomology is included in this category, because many animal diseases can "jump species" and become a human health threat, for example, bovine encephalitis. Medical entomology also includes scientific research on the behavior, ecology, and epidemiology of arthropod disease vectors, and involves a tremendous outreach to the public, including local and state officials and other stake holders in the interest of public safety.

A reverse zoonosis, also known as a zooanthroponosis or anthroponosis, is a pathogen reservoired in humans that is capable of being transmitted to non-human animals.

<span class="mw-page-title-main">Mosquito-borne disease</span> Diseases caused by bacteria, viruses or parasites transmitted by mosquitoes

Mosquito-borne diseases or mosquito-borne illnesses are diseases caused by bacteria, viruses or parasites transmitted by mosquitoes. Nearly 700 million people get a mosquito-borne illness each year resulting in over 725,000 deaths.

<span class="mw-page-title-main">2007 Yap Islands Zika virus outbreak</span>

The 2007 Yap Islands Zika virus outbreak represented the first time Zika virus had been detected outside Africa and Asia. It occurred in the Yap Islands, an island chain in the Federated States of Micronesia. Zika virus (ZIKV) is a vector-borne flavivirus in the same family as yellow fever, dengue, West Nile and Japanese encephalitis viruses.

<span class="mw-page-title-main">Lethal ovitrap</span> Mosquito-killing trap

A lethal ovitrap is a device which attracts gravid female container-breeding mosquitoes and kills them. The traps halt the insect's life cycle by killing adult insects and stopping reproduction. The original use of ovitraps was to monitor the spread and density of Aedes and other container-breeding mosquito populations by collecting eggs which could be counted, or hatched to identify the types of insects. Since its conception, researchers found that adding lethal substances to the ovitraps could control the populations of these targeted species. These traps are called lethal ovitraps. They primarily target Aedes aegypti and Aedes albopictus mosquitoes, which are the main vectors of dengue fever, Zika virus, west Nile virus, yellow fever, and chikungunya.

Oxitec is a UK-based, US-owned biotechnology company that develops genetically modified insects in order to improve public health and food security through insect control. The insects act as biological insecticides. Insects are controlled without the use of chemical insecticides. Instead, the insects are genetically engineered to be unable to produce offspring. The company claims that this technology is more effective than insecticides and more environmentally friendly.

Aedes mediovittatus, the "Caribbean treehole mosquito," was first described in 1906 as Stegomyia mediovittata by Daniel W. Coquillett.

An ovillanta is a type of mosquito trap designed by researchers at Laurentian University in Ontario, Canada, and tested in cooperation with the Ministry of Health in Guatemala and with researchers in Mexico. The simple, low-cost trap allows efficient collection and disposal of mosquito eggs and larvae.

<i>Drosophila innubila</i> Species of fly

Drosophila innubila is a species of vinegar fly restricted to high-elevation woodlands in the mountains of the southern USA and Mexico, which it likely colonized during the last glacial period. Drosophila innubila is a kind of mushroom-breeding Drosophila, and member of the Drosophila quinaria species group. Drosophila innubila is best known for its association with a strain of male-killing Wolbachia bacteria. These bacteria are parasitic, as they drain resources from the host and cause half the infected female's eggs to abort. However Wolbachia may offer benefits to the fly's fitness in certain circumstances. The D. innubila genome was sequenced in 2019.

References

  1. Elizabeth McGraw publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  2. Elizabeth McGraw publications from Europe PubMed Central
  3. 1 2 Luciano A Moreira; Iñaki Iturbe-Ormaetxe; Jason A Jeffery; et al. (1 December 2009). "A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium". Cell . 139 (7): 1268–1278. doi:10.1016/J.CELL.2009.11.042. ISSN   0092-8674. PMID   20064373. Wikidata   Q29616261.
  4. 1 2 Hoffmann AA; Montgomery BL; Popovici J; et al. (24 August 2011). "Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission". Nature . 476 (7361): 454–7. doi:10.1038/NATURE10356. ISSN   1476-4687. PMID   21866160. Wikidata   Q29615114.
  5. 1 2 Martin Wu; Ling V Sun; Jessica Vamathevan; et al. (March 2004). "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements". PLOS Biology . 2 (3): E69. doi:10.1371/JOURNAL.PBIO.0020069. ISSN   1544-9173. PMC   368164 . PMID   15024419. Wikidata   Q21563646.
  6. McGraw, Elizabeth Ann (1998). Molecular evolution of invasive bacterial pathogens (PhD thesis). Pennsylvania State University. OCLC   299248804. ProQuest   304463293.
  7. "Professor Elizabeth McGraw". zoo.ox.ac.uk. Retrieved 2023-02-28.
  8. 1 2 "McGraw elected as a Fellow of the American Academy of Microbiology | Penn State University". psu.edu. Retrieved 2023-02-28.
  9. 1 2 "Combating mosquito-borne diseases with bacteria | Penn State University". psu.edu. Retrieved 2023-02-28.
  10. "Global warming may limit spread of dengue fever, new research finds | Penn State University". psu.edu. Retrieved 2023-02-28.
  11. "People". vectorbiologygroup.com. Retrieved 2023-02-28.