Elizabeth Sattely

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Elizabeth S. Sattely is an American scientist and biotechnology engineer. She is an Associate Professor of Chemical Engineering in the Department of Chemical Engineering, an HHMI investigator, [1] and a ChEM-H Faculty Fellow [2] at Stanford University.

Contents

Education

Dr. Sattely completed her graduate training at Boston College in organic chemistry with Amir Hoveyda and her postdoctoral studies in biochemistry at Harvard Medical School with Christopher T. Walsh, where she worked on natural product biosynthesis in bacteria. [3]

Research

Inspired by human reliance on plants and plant-derived molecules for food and medicine, the Sattely laboratory is focused on the discovery and engineering of plant metabolic pathways to make molecules that can enhance human health. [4] [5] These engineering targets include:

Beyond fundamental research into biosynthesis of molecules important for human health, the Sattely lab also works on metabolites important for plant health, both in the realm of nutrient acquisition and defense response. Research is not only dedicated to molecules within the plant itself, but also to molecules involved in plant-microbe interactions. Examples are:

Another part of the laboratory involves the study of plant-derived value added small molecules, such as:

Awards

Work in the Sattely lab has been recognized by an NIH New Innovator Award, a DOE Early Career Award, an HHMI-Simons Faculty Scholar Award, a DARPA Young Investigator Award, and a AAAS Mason Award for Women in the Chemical Sciences. [15]

Personal life

Elizabeth Sattely is married to Dr. Michael Fischbach, associate professor of bioengineering at Stanford University. Her favorite bacterium is Azospirillum brasilense . [16]

Publications

Related Research Articles

<span class="mw-page-title-main">Cytokinin</span> Class of plant hormones promoting cell division

Cytokinins (CK) are a class of plant hormones that promote cell division, or cytokinesis, in plant roots and shoots. They are involved primarily in cell growth and differentiation, but also affect apical dominance, axillary bud growth, and leaf senescence.

Gibberellins (GAs) are plant hormones that regulate various developmental processes, including stem elongation, germination, dormancy, flowering, flower development, and leaf and fruit senescence. GAs are one of the longest-known classes of plant hormone. It is thought that the selective breeding of crop strains that were deficient in GA synthesis was one of the key drivers of the "green revolution" in the 1960s, a revolution that is credited to have saved over a billion lives worldwide.

<span class="mw-page-title-main">Cytochrome P450</span> Class of enzymes

Cytochromes P450 are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In 1963, Estabrook, Cooper, and Rosenthal described the role of CYP as a catalyst in steroid hormone synthesis and drug metabolism. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.

<span class="mw-page-title-main">Phytoalexin</span> Class of chemical compounds

Phytoalexins are antimicrobial substances, some of which are antioxidative as well. They are defined, not by their having any particular chemical structure or character, but by the fact that they are defensively synthesized de novo by plants that produce the compounds rapidly at sites of pathogen infection. In general phytoalexins are broad spectrum inhibitors; they are chemically diverse, and different chemical classes of compounds are characteristic of particular plant taxa. Phytoalexins tend to fall into several chemical classes, including terpenoids, glycosteroids, and alkaloids; however the term applies to any phytochemicals that are induced by microbial infection.

<span class="mw-page-title-main">Stilbenoid</span> Class of chemical compounds

Stilbenoids are hydroxylated derivatives of stilbene. They have a C6–C2–C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Most stilbenoids are produced by plants, and the only known exception is the antihelminthic and antimicrobial stilbenoid, 2-isopropyl-5-[(E)-2-phenylvinyl]benzene-1,3-diol, biosynthesized by the Gram-negative bacterium Photorhabdus luminescens.

<span class="mw-page-title-main">Xylan</span> A plant cell wall polysaccharide

Xylan is a type of hemicellulose, a polysaccharide consisting mainly of xylose residues. It is found in plants, in the secondary cell walls of dicots and all cell walls of grasses. Xylan is the third most abundant biopolymer on Earth, after cellulose and chitin.

The non-mevalonate pathway—also appearing as the mevalonate-independent pathway and the 2-C-methyl-D-erythritol 4-phosphate/1-deoxy-D-xylulose 5-phosphate (MEP/DOXP) pathway—is an alternative metabolic pathway for the biosynthesis of the isoprenoid precursors isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). The currently preferred name for this pathway is the MEP pathway, since MEP is the first committed metabolite on the route to IPP.

Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis.

Resistance genes (R-Genes) are genes in plant genomes that convey plant disease resistance against pathogens by producing R proteins. The main class of R-genes consist of a nucleotide binding domain (NB) and a leucine rich repeat (LRR) domain(s) and are often referred to as (NB-LRR) R-genes or NLRs. Generally, the NB domain binds either ATP/ADP or GTP/GDP. The LRR domain is often involved in protein-protein interactions as well as ligand binding. NB-LRR R-genes can be further subdivided into toll interleukin 1 receptor (TIR-NB-LRR) and coiled-coil (CC-NB-LRR).

<span class="mw-page-title-main">Castanospermine</span> Chemical compound

Castanospermine is an indolizidine alkaloid first isolated from the seeds of Castanospermum australe. It is a potent inhibitor of some glucosidase enzymes and has antiviral activity in vitro and in mouse models.

Arabinogalactan-proteins (AGPs) are highly glycosylated proteins (glycoproteins) found in the cell walls of plants. Each one consists of a protein with sugar molecules attached. They are members of the wider class of hydroxyproline (Hyp)-rich cell wall glycoproteins, a large and diverse group of glycosylated wall proteins.

<span class="mw-page-title-main">Naturally occurring phenols</span> Group of chemical compounds

In biochemistry, naturally occurring phenols are natural products containing at least one phenol functional group. Phenolic compounds are produced by plants and microorganisms. Organisms sometimes synthesize phenolic compounds in response to ecological pressures such as pathogen and insect attack, UV radiation and wounding. As they are present in food consumed in human diets and in plants used in traditional medicine of several cultures, their role in human health and disease is a subject of research. Some phenols are germicidal and are used in formulating disinfectants.

Glyceollins are a family of prenylated pterocarpans found in ineffective types of nodule in soybean in response to symbiotic infection.

Tyrosine N-monooxygenase (EC 1.14.13.41, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Camalexin</span> Chemical compound

Camalexin (3-thiazol-2-yl-indole) is a simple indole alkaloid found in the plant Arabidopsis thaliana and other crucifers. The secondary metabolite functions as a phytoalexin to deter bacterial and fungal pathogens.

<span class="mw-page-title-main">Pisatin</span> Chemical compound

Pisatin (3-hydroxy-7-methoxy-4′,5′-methylenedioxy-chromanocoumarane) is the major phytoalexin made by the pea plant Pisum sativum. It was the first phytoalexin to be purified and chemically identified. The molecular formula is C17H14O6.

Michael Andrew Fischbach is an American chemist, microbiologist, and geneticist. He is an associate professor of Bioengineering and ChEM-H Faculty Fellow at Stanford University and a Chan Zuckerberg Biohub Investigator.

The MSU-DOE Plant Research Laboratory (PRL), commonly referred to as Plant Research Lab, is a research institute funded to a large extent by the U.S. Department of Energy Office of Science and located at Michigan State University (MSU) in East Lansing, Michigan. The Plant Research Lab was founded in 1965, and it currently includes twelve laboratories that conduct collaborative basic research into the biology of diverse photosynthetic organisms, including plants, bacteria, and algae, in addition to developing new technologies towards addressing energy and food challenges.

Lynette Cegelski is an American physical chemist and chemical biologist who studies extracellular structures such as biofilms and membrane proteins. She is an associate professor of chemistry and, by courtesy, of chemical engineering at Stanford University. She is a Stanford Bio-X and Stanford ChEM-H affiliated faculty member.

Christoph Benning is a German–American plant biologist. He is an MSU Foundation Professor and University Distinguished Professor at Michigan State University. Benning's research into lipid metabolism in plants, algae and photosynthetic bacteria, led him to be named Editor-in-Chief of The Plant Journal in October 2008.

References

  1. ↑ "Elizabeth Sattely, PhD". HHMI.org. Retrieved 2018-11-05.
  2. ↑ "Elizabeth Sattely | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  3. ↑ Sattely, Elizabeth S.; Meek, Simon J.; Malcolmson, Steven J.; Schrock, Richard R.; Hoveyda, Amir H. (2009-01-28). "Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis". Journal of the American Chemical Society. 131 (3): 943–953. doi:10.1021/ja8084934. ISSN   1520-5126. PMC   2819342 . PMID   19113867.
  4. ↑ Anarat-Cappillino, Gülbenk; Sattely, Elizabeth S (January 2014). "The chemical logic of plant natural product biosynthesis". Current Opinion in Plant Biology. 19: 51–58. doi:10.1016/j.pbi.2014.03.007. ISSN   1369-5266. PMC   6863165 . PMID   24727074.
  5. ↑ Lau, Warren; Fischbach, Michael A.; Osbourn, Anne; Sattely, Elizabeth S. (2014-06-10). "Key Applications of Plant Metabolic Engineering". PLOS Biology. 12 (6): e1001879. doi: 10.1371/journal.pbio.1001879 . ISSN   1545-7885. PMC   4051588 . PMID   24915445.
  6. ↑ Klein, Andrew P.; Anarat-Cappillino, Gülbenk; Sattely, Elizabeth S. (2013-10-21). "Minimum Set of Cytochromes P450 for Reconstituting the Biosynthesis of Camalexin, a MajorArabidopsisAntibiotic". Angewandte Chemie International Edition. 52 (51): 13625–13628. doi:10.1002/anie.201307454. ISSN   1433-7851. PMC   3867539 . PMID   24151049.
  7. ↑ Klein, Andrew P; Sattely, Elizabeth S (2015-09-21). "Two cytochromes P450 catalyze S-heterocyclizations in cabbage phytoalexin biosynthesis". Nature Chemical Biology. 11 (11): 837–839. doi:10.1038/nchembio.1914. ISSN   1552-4450. PMC   4731101 . PMID   26389737.
  8. ↑ Klein, Andrew P.; Sattely, Elizabeth S. (2017-02-21). "Biosynthesis of cabbage phytoalexins from indole glucosinolate". Proceedings of the National Academy of Sciences. 114 (8): 1910–1915. doi: 10.1073/pnas.1615625114 . ISSN   0027-8424. PMC   5338394 . PMID   28154137.
  9. ↑ Lau, Warren; Sattely, Elizabeth S. (2015-09-10). "Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone". Science. 349 (6253): 1224–1228. Bibcode:2015Sci...349.1224L. doi: 10.1126/science.aac7202 . ISSN   0036-8075. PMC   6861171 . PMID   26359402.
  10. ↑ Rajniak, Jakub; Giehl, Ricardo F. H.; Chang, Evelyn; Murgia, Irene; von Wirén, Nicolaus; Sattely, Elizabeth S. (2018-03-26). "Biosynthesis of redox-active metabolites in response to iron deficiency in plants". Nature Chemical Biology. 14 (5): 442–450. doi:10.1038/s41589-018-0019-2. ISSN   1552-4450. PMC   6693505 . PMID   29581584.
  11. ↑ Chen, Yun Chu; Holmes, Eric; Rajniak, Jakub; Kim, Jung-Gun; Tang, Sandy; Fischer, Curt; Mudgett, Mary Beth; Sattely, Elizabeth (2018-03-25). "N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis". bioRxiv: 288449. doi: 10.1101/288449 .
  12. ↑ "Group Members | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  13. ↑ LeFevre, Gregory H.; Portmann, Andrea C.; Müller, Claudia E.; Sattely, Elizabeth S.; Luthy, Richard G. (2016-01-08). "Plant Assimilation Kinetics and Metabolism of 2-Mercaptobenzothiazole Tire Rubber Vulcanizers by Arabidopsis". Environmental Science & Technology. 50 (13): 6762–6771. Bibcode:2016EnST...50.6762L. doi:10.1021/acs.est.5b04716. ISSN   0013-936X. PMID   26698834.
  14. ↑ "Group Members | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  15. ↑ "Elizabeth Sattely | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  16. ↑ Introduction to Dr. Sattely's talk at the Center for Molecular Analysis and Design, 2018 Symposium
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