Ellen Rothenberg (scientist)

Last updated
Ellen V. Rothenberg
Ellen Rothenberg at the NIH.jpg
Rothenberg speaks at the National Institutes of Health in 2018
Born1952 (age 7172)
Alma mater Massachusetts Institute of Technology
Harvard University
Scientific career
Institutions California Institute of Technology
Memorial Sloan-Kettering Cancer Center
Thesis In vitro synthesis of biologically active DNA of murine leukemia virus.  (1977)
Website T-cell developmental gene network

Ellen V. Rothenberg (born 1952) is an American biologist who is an Edward B. Lewis Professor of Biology at the California Institute of Technology. She investigates the molecular mechanisms that underpin lineage choice. She is an elected fellow of the American Association for the Advancement of Science, American Academy of Arts and Sciences and the National Academy of Sciences.

Contents

Early life and education

Rothenberg describes her upbringing as "sex-blind". She credits her parents with giving her a strong sense of one's potential and says her father "taught [her] math and logic to the point that [she] got in trouble with [her] teachers". As a child, Rothenberg originally wanted to become a physicist, but her high school biology classes inspired her to pursue biochemistry. [1] Her high school teachers taught her about protein structure and how their structures confer biological function. While Rothenberg was an undergraduate student at Harvard University, [2] her tutor, Boris Magasanik, inspired her to work on gene regulation. [1] After earning her bachelor's degree, Rothenberg started a MD–PhD program offered jointly by Harvard Medical School and the Massachusetts Institute of Technology (MIT). [1] She eventually dropped the MD but continued, at MIT, her PhD research with David Baltimore. She was the first to synthesize in vitro the genome of a retrovirus. [1] She completed her doctoral research in the Department of Biology and Center for Cancer Research in 1977. Rothenberg was a Jane Coffin Childs postdoctoral fellow with Edward Boyse at the Memorial Sloan Kettering Cancer Center in New York City. [3]

Research and career

In 1979, Rothenberg was appointed to the faculty at the Salk Institute for Biological Studies, where she spent three years before moving to the California Institute of Technology. [3] Rothenberg investigates the molecular mechanisms that underpin lineage selection. This includes the processes that determine the differentiation of hematopoietic stem cells into T cells. There are several steps to this process, in which the multi-potentiality of stem cells are reduced whilst the T-cell specific differentiation events start.[ citation needed ]

Rothenberg studies the transcription factors that induce gene expression to guide development of T-lineage cells. [4] She has modeled the gene networks involved and the interactions of transcription factors and chromatin. She identified that subtle changes in these pathways can predispose to autoimmunity.

Awards and honors

Selected publications

Related Research Articles

<span class="mw-page-title-main">David Baltimore</span> American biologist (born 1938)

David Baltimore is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Technology (Caltech), where he served as president from 1997 to 2006. He founded the Whitehead Institute and directed it from 1982 to 1990. In 2008, he served as president of the American Association for the Advancement of Science in 2008.

<span class="mw-page-title-main">Pamela J. Bjorkman</span> American biochemist

Pamela Jane Bjorkman NAS, AAAS is an American biochemist and molecular biologist. She is the David Baltimore Professor of Biology and Biological Engineering at the California Institute of Technology (Caltech). Her research centers on the study of the three-dimensional structures of proteins related to Class I MHC, or Major Histocompatibility Complex, proteins of the immune system, and proteins involved in the immune responses to viruses. Bjorkman's goal is to improve current therapeutic applications. Bjorkman is most well known as a pioneer in the field of structural biology.

<span class="mw-page-title-main">Alexander Varshavsky</span>

Alexander J. Varshavsky is a Russian-American biochemist and geneticist. He works at the California Institute of Technology (Caltech) as the Morgan Professor of Biology. Varshavsky left Russia in 1977, emigrating to United States.

<span class="mw-page-title-main">Eva Nogales</span> Biophysicist, professor

Eva Nogales is a Spanish-American biophysicist at the Lawrence Berkeley National Laboratory and a professor at the University of California, Berkeley, where she served as head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015–2020). She is a Howard Hughes Medical Institute investigator.

Eric Harris Davidson was an American developmental biologist at the California Institute of Technology. Davidson was best known for his pioneering work on the role of gene regulation in evolution, on embryonic specification and for spearheading the effort to sequence the genome of the purple sea urchin, Strongylocentrotus purpuratus. He devoted a large part of his professional career to developing an understanding of embryogenesis at the genetic level. He wrote many academic works describing his work, including a textbook on early animal development.

Barbara J. Meyer is a biologist and genetist, noted for her pioneering research on lambda phage, a virus that infects bacteria; discovery of the master control gene involved in sex determination; and studies of gene regulation, particularly dosage compensation. Meyer's work has revealed mechanisms of sex determination and dosage compensation—that balance X-chromosome gene expression between the sexes in Caenorhabditis elegans that continue to serve as the foundation of diverse areas of study on chromosome structure and function today.

Alice Yen-Ping Ting is Taiwanese-born American chemist. She is a professor of genetics, of biology, and by courtesy, of chemistry at Stanford University. She is also a Chan Zuckerberg Biohub investigator and a member of the National Academy of Sciences.

Michael B. Elowitz is a biologist and professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology, and investigator at the Howard Hughes Medical Institute. In 2007 he was the recipient of the Genius grant, better known as the MacArthur Fellows Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology. He was the first to show how inherently random effects, or 'noise', in gene expression could be detected and quantified in living cells, leading to a growing recognition of the many roles that noise plays in living cells. His work in Synthetic Biology and Noise represent two foundations of the field of Systems Biology. Since then, his laboratory has contributed to the development of synthetic biological circuits that perform a range of functions inside cells, and revealed biological circuit design principles underlying epigenetic memory, cell fate control, cell-cell communication, and multicellular behaviors.

Laura Lee Kiessling is an American chemist and the Novartis Professor of Chemistry at the Massachusetts Institute of Technology. Kiessling's research focuses on elucidating and exploiting interactions on the cell surface, especially those mediated by proteins binding to carbohydrates. Multivalent protein-carbohydrate interactions play roles in cell-cell recognition and signal transduction. Understanding and manipulating these interactions provides tools to study biological processes and design therapeutic treatments. Kiessling's interdisciplinary research combines organic synthesis, polymer chemistry, structural biology, and molecular and cell biology.

<span class="mw-page-title-main">Ming-Ming Zhou</span>

Ming-Ming Zhou is an American scientist whose specification is structural and chemical biology, NMR spectroscopy, and drug design. He is the Dr. Harold and Golden Lamport Professor and Chairman of the Department of Pharmacological Sciences. He is also the co-director of the Drug Discovery Institute at the Icahn School of Medicine at Mount Sinai and Mount Sinai Health System in New York City, as well as Professor of Sciences. Zhou is an elected fellow of the American Association for the Advancement of Science.

Judith Kimble is a Henry Vilas Professor of Biochemistry, Molecular Biology, Medical Genetics and Cell and Regenerative Biology at the University of Wisconsin–Madison and Investigator with the Howard Hughes Medical Institute (HHMI). Kimble’s research focuses on the molecular regulation of animal development.

<span class="mw-page-title-main">Barbara Wold</span> Professor of Molecular Biology

Barbara J. Wold is the Bren Professor of Molecular Biology, the principal investigator of the Wold Lab at the California Institute of Technology (Caltech) and the principal investigator of the Functional Genomics Resource Center at the Beckman Institute at Caltech. Wold was director of the Beckman Institute at Caltech from 2001 to 2011.

<span class="mw-page-title-main">Doris Tsao</span> American neuroscientist

Doris Ying Tsao is an American systems neuroscientist and professor of biology at the University of California, Berkeley. She was formerly on the faculty at the California Institute of Technology. She is recognized for pioneering the use of fMRI with single-unit electrophysiological recordings and for discovering the macaque face patch system for face perception. She is a Howard Hughes Medical Institute Investigator and the director of the T&C Chen Center for Systems Neuroscience. She won a MacArthur "Genius" fellowship in 2018. Tsao was elected a member of the National Academy of Sciences in 2020.

<span class="mw-page-title-main">Mary B. Kennedy</span> American biochemist and neuroscientist

Mary Bernadette Kennedy is an American biochemist and neuroscientist. She is a member of the American Academy of Arts and Sciences, and is the Allen and Lenabelle Davis Professor of Biology at the California Institute of Technology, where she has been a member of the faculty since 1981. Her research focuses on the molecular mechanisms of synaptic plasticity, the process underlying formation of memory in the central nervous system. Her lab uses biochemical and molecular biological methods to study the protein machinery within a structure called the postsynaptic density. Kennedy has published over 100 papers with over 20,000 total citations.

<span class="mw-page-title-main">Rebecca Heald</span> American cell and developmental biologist

Rebecca W. Heald is an American professor of cell and developmental biology. She is currently a Professor in the Department of Molecular & Cell Biology at the University of California, Berkeley. In May 2019, she was elected to the National Academy of Sciences. She has published over 120 research articles in peer reviewed journals.

<span class="mw-page-title-main">Denise Montell</span> American biochemist and researcher

Denise Johnson Montell is an American biologist who is the Duggan Professor of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara. Her research considers the oogenesis process in Drosophila and border cell migration. She has served as president of the Genetics Society of America and was elected to the National Academy of Sciences in 2021.

Hongkui Zeng is the Director of the Allen Institute for Brain Science in Seattle, where she leads the creation of open-access datasets and tools to accelerate neuroscience discovery. In 2011-2014 Zeng led the team that created the Allen Mouse Brain Connectivity Atlas, which indicates which regions of the mouse brain are connected to which other regions. Since then, she has led the creation of atlases of neuronal cell types in the brain of humans and mice.

Iva Susan Greenwald is an American biologist who is Professor of Cell and Molecular Biology at Columbia University. She studies cell-cell interactions and cell fate specification in C. elegans. She is particularly interested in LIN-12/Notch proteins, which is the receptor of one of the major signalling systems that determines the fate of cells.

<span class="mw-page-title-main">Yardena Samuels</span> Israeli molecular biologist

Yardena Samuels or Samuels-Lev is an Israeli molecular biologist who is the Director of the Ekard Institute for Cancer Diagnosis Research at the Weizmann Institute of Science. Her research considers the genetic mutations of melanoma.

<span class="mw-page-title-main">Elaine Hsiao</span> American biologist and academic

Elaine Yih-Nien Hsiao is an American biologist who is Professor in Biological Sciences at University of California, Los Angeles. Her research considers the microbes that impact human health. She was a 2022 Laureate for the Blavatnik Awards for Young Scientists.

References

  1. 1 2 3 4 "Interview by Ute Deichmann with Ellen Rothenberg" (PDF).
  2. "Ellen Rothenberg". www.asi2018.org. Retrieved 2021-05-07.
  3. 1 2 "Speakers". alleninstitute.org. Retrieved 2021-05-07.
  4. "T-Cell Development GRN:Personnel". www.its.caltech.edu. Retrieved 2021-05-07.
  5. "Distinguished Lecturers". American Association of Immunologists . Archived from the original on 2020-08-09.
  6. "Richard P. Feynman Prize for Excellence in Teaching | Office of the Provost". provost.caltech.edu. Archived from the original on 2019-10-08. Retrieved 2021-05-07.
  7. "Three Caltech Faculty Named AAAS Fellows". California Institute of Technology. Retrieved 2021-05-07.
  8. "American Academy of Arts and Sciences Elects Two from Caltech". California Institute of Technology. Retrieved 2021-05-07.
  9. "2021 NAS Election". www.nasonline.org. Retrieved 2021-05-07.