FARSB

FARSB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4G
Identifiers
Aliases	FARSB , FARSLB, FRSB, PheHB, PheRS, HSPC173, phenylalanyl-tRNA synthetase beta subunit, phenylalanyl-tRNA synthetase subunit beta, NEDBLLA, RILDBC, RILDBC1
External IDs	OMIM: 609690 MGI: 1346035 HomoloGene: 4160 GeneCards: FARSB
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q36.1 Start 222,566,899 bp [1] End 222,656,092 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C4 Start 78,394,612 bp [2] End 78,465,534 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell pancreatic ductal cell middle temporal gyrus Brodmann area 23 sperm deltoid muscle spinal ganglia quadriceps femoris muscle pons vastus lateralis muscle Top expressed in primitive streak Paneth cell condyle fossa secondary oocyte barrel cortex external carotid artery substantia nigra internal carotid artery motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ligase activity nucleotide binding aminoacyl-tRNA ligase activity magnesium ion binding ATP binding RNA binding phenylalanine-tRNA ligase activity protein binding Cellular component membrane cytosol cytoplasm phenylalanine-tRNA ligase complex Biological process tRNA aminoacylation for protein translation protein biosynthesis protein heterotetramerization phenylalanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10056 23874 Ensembl ENSG00000116120 ENSMUSG00000026245 UniProt Q9NSD9 Q9WUA2 RefSeq (mRNA) NM_005687 NM_001278075 NM_011811 RefSeq (protein) NP_005678 NP_001265004 NP_035941 Location (UCSC) Chr 2: 222.57 – 222.66 Mb Chr 1: 78.39 – 78.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene. ^{[5] [6]}

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000116120 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026245 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rodova M, Ankilova V, Safro MG (Apr 1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem Biophys Res Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID   10049785.
6. "Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit".

Further reading

• Archambault de Vencay J, Thomes JC, Julien R (1978). "Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium". FEBS Lett. 89 (1): 98–102. doi: 10.1016/0014-5793(78)80531-6 . PMID   658405. S2CID   45824342.
• Nazarenko IA, Peterson ET, Zakharova OD, et al. (1992). "Recognition nucleotides for human phenylalanyl-tRNA synthetase". Nucleic Acids Res. 20 (3): 475–8. doi:10.1093/nar/20.3.475. PMC   310410 . PMID   1741281.
• Sen S, Zhou H, Ripmaster T, et al. (1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi: 10.1073/pnas.94.12.6164 . PMC   21020 . PMID   9177188.
• Zhou X, Richon VM, Ngo L, et al. (1999). "Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation". Gene. 233 (1–2): 13–9. doi:10.1016/S0378-1119(99)00170-5. PMID   10375616.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Moor N, Linshiz G, Safro M (2002). "Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes". Protein Expr. Purif. 24 (2): 260–7. doi:10.1006/prep.2001.1560. PMID   11858721.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Moor N, Lavrik O, Favre A, Safro M (2003). "Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end". Biochemistry. 42 (36): 10697–708. doi:10.1021/bi034732q. PMID   12962494.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Yu XY, Finn J, Hill JM, et al. (2004). "A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases". Bioorg. Med. Chem. Lett. 14 (5): 1339–42. doi:10.1016/j.bmcl.2003.11.081. PMID   14980694.
• Vasil'eva IA, Bogachev VS, Favre A, et al. (2005). "Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase". Biochemistry Mosc. 69 (2): 143–53. doi:10.1023/B:BIRY.0000018944.53390.44. PMID   15000680. S2CID   2285905.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.

External links

• FARSB human gene location in the UCSC Genome Browser .
• FARSB human gene details in the UCSC Genome Browser .