FASTKD5

FASTKD5
Identifiers
Aliases	FASTKD5 , dJ1187M17.5, FAST kinase domains 5
External IDs	MGI: 2139469 HomoloGene: 36400 GeneCards: FASTKD5
Gene location (Human)
Chr.	Chromosome 20 (human) [1]
End	3,159,897 bp [1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse) [2]
End	130,630,027 bp [2]
Gene ontology
Molecular function	• protein kinase activity ; • rRNA binding ; • protein binding ; • RNA binding ;
Cellular component	• ribonucleoprotein granule ; • mitochondrial nucleoid ; • mitochondrion ;
Biological process	• cellular respiration ; • protein phosphorylation ; • mRNA processing ; • mitochondrial RNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	60493
	380601
	ENSG00000215251
	ENSMUSG00000079043
	Q7L8L6
	Q7TMV3
	NM_021826
	NM_001146084 ; NM_198176
	NP_068598
	NP_001139556 ; NP_937819
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 31, 2019

FAST kinase domain-containing protein 5 (FASTKD5) is a protein that in humans is encoded by the FASTKD5 gene on chromosome 20.^[5]^[6] This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress.^[7]^[8] FASTKD5 is also required for RNA granules to process precursor mRNAs not flanked by tRNAs.^[9]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Structure

FASTKD5 shares structural characteristics of the FASTKD family, including an amino terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and a RNA-binding domain (RAP).^[7]^[8] The mitochondrial targeting domain directs FASTKD5 to be imported into the mitochondria. Though the functions of the C-terminal domains are unknown, RAP possibly binds RNA during trans-splicing.^[7] This protein forms a 103 kDa protein complex with unidentified proteins.^[9]

Function

As a member of the FASTKD family, FASTKD5 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD5 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria.^[7] FASTKD5 also localizes to RNA granules, membraneless bodies containing mRNAs and associated RNA-binding proteins, where it facilitates posttranscriptional RNA processing. This protein is required for the maturation of precursor mRNAs that are not flanked by tRNAs, and thus cannot be processed by the canonical mRNA maturation pathway.^[9]

Clinical significance

Though the link to FASTKD5 remains uncharacterized, the accumulation of abnormal RNA granules can lead to some neurodegenerative diseases.^[9]

Interactions

FASTKD5 has been shown to interact with:

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000215251 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079043 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ UniProt: Q7L8L6
↑ "Entrez Gene: FAST kinase domains 5".
1 2 3 4 Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690  . PMID 20869947.
1 2 Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH (Jun 2011). "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2". Molecular and Cellular Biology. 31 (11): 2287–98. doi:10.1128/MCB.01381-10. PMC 3133243  . PMID 21444724.
1 2 3 4 5 6 7 Antonicka H, Shoubridge EA (Feb 2015). "Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis". Cell Reports. 10: 920–932. doi:10.1016/j.celrep.2015.01.030. PMID 25683715.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000215251 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079043 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[uniprot-5] UniProt: Q7L8L6

[entrez-6] "Entrez Gene: FAST kinase domains 5".

[pmid20869947-7] 1 2 3 4 Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P (Oct 2010). "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration". Biochemical and Biophysical Research Communications. 401 (3): 440–6. doi:10.1016/j.bbrc.2010.09.075. PMC 2963690  . PMID 20869947.

[pmid21444724-8] 1 2 Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH (Jun 2011). "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2". Molecular and Cellular Biology. 31 (11): 2287–98. doi:10.1128/MCB.01381-10. PMC 3133243  . PMID 21444724.

[pmid25683715-9] 1 2 3 4 5 6 7 Antonicka H, Shoubridge EA (Feb 2015). "Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis". Cell Reports. 10: 920–932. doi:10.1016/j.celrep.2015.01.030. PMID 25683715.